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Xenobiotica
the fate of foreign compounds in biological systems
Volume 9, 1979 - Issue 2
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Original Article

Identification of Urinary and Biliary Metabolites of Alprenolol in the Rat

K.-J. Hoffmann Research Laboratories, AB Hässle, Fack, S-431 20, Mölndal, Sweden
,
A. Arfwidsson Research Laboratories, AB Hässle, Fack, S-431 20, Mölndal, Sweden
,
K. O. Borg Research Laboratories, AB Hässle, Fack, S-431 20, Mölndal, Sweden
&
I. Skånberg Research Laboratories, AB Hässle, Fack, S-431 20, Mölndal, Sweden
Pages 93-106 | Received 15 May 1978, Published online: 30 Sep 2009

Citations (13)

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K.-J. Hoffmann, I. Skånberg & K. O. Borg. (1979) Biotransformation of Alprenolol in Dog, Guinea-pig and Rat Liver Microsomes. Xenobiotica 9:2, pages 79-91.
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Articles from other publishers (12)

Ugo Bussy, Marcel Delaforge, Chaimaâ El-Bekkali, Véronique Ferchaud-Roucher, Michel Krempf, Illa Tea, Nicolas Galland, Denis Jacquemin & Mohammed Boujtita. (2013) Acebutolol and alprenolol metabolism predictions: comparative study of electrochemical and cytochrome P450-catalyzed reactions using liquid chromatography coupled to high-resolution mass spectrometry. Analytical and Bioanalytical Chemistry 405:18, pages 6077-6085.
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Bengt Norén, Signhild Strōmberg, Ōrjan Ericsson, Lars-Inge Olsson & Pinchas Moses. (1985) Biotransformation of terodiline I. Identification of metabolites in dog urine by mass spectrometry. Biological Mass Spectrometry 12:8, pages 367-379.
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R. L. Smith. (1985) Polymorphic metabolism of the ?-adrenoreceptor blocking drugs and its clinical relevance. European Journal of Clinical Pharmacology 28:S1, pages 77-84.
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O. Tomčíková, Š. Bezek, M. Ďurišová, V. Faberová, M. Zemánek & T. Trnovec. (2006) Biliary excretion and enterohepatic circulation of two beta‐adrenergic blocking drugs, exaprolol and propranolol in rats. Biopharmaceutics & Drug Disposition 5:2, pages 153-162.
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W. Dieterle & J. W. Faigle. 1983. Drug Metabolite Isolation and Determination. Drug Metabolite Isolation and Determination 13 32 .
Louise M. Brown & Anthony W. Ford-Hutchinson. (1982) The destruction of cytochrome P-450 by alclofenac: Possible involvement of an epoxide metabolite. Biochemical Pharmacology 31:2, pages 195-199.
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Josef Pitha, Jordan Zjawiony, Robert J. Lefkowitz & Marc G. Caron. (2003) Polymeric drugs by direct copolymerization: Polymer of β‐adrenergic antagonist alprenolol and its binding to receptors and antibodies. Die Makromolekulare Chemie 182:7, pages 1945-1950.
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J.A. Slack, A.W. Ford-Hutchinson, M. Richold & B.C.K. Choi. (1981) Some biochemical and pharmacological properties of an epoxide metabolite of alclofenac. Chemico-Biological Interactions 34:1, pages 95-107.
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Colin F. Poole, Lars Johansson & Jörgen Vessman. (1980) Formation of electron-capturing derivatives of alprenolol by transboronation. Journal of Chromatography A 194:3, pages 365-377.
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A. L. Burlingame, Thomas A. Baillie, Peter J. Derrick & O. S. Chizhov. (2002) Mass spectrometry. Analytical Chemistry 52:5, pages 214-258.
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Colin F. Poole & Albert Zlatkis. (1980) Cyclic derivatives for the selective chromatographic analysis of bifunctional compounds. Journal of Chromatography A 184:2, pages 99-183.
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K. -J. Hoffmann, I. Skånberg & K. O. Borg. (1979) Species differences in the metabolism of pamatolol, a cardioselective beta — adrenoceptor antagonist. European Journal of Drug Metabolism and Pharmacokinetics 4:3, pages 163-173.
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