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Xenobiotica
the fate of foreign compounds in biological systems
Volume 9, 1979 - Issue 2
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Original Article

Comparison of rate of Hepatic Metabolism in vitro and Half-Life for Antipyrine in vivo in Three Species

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Pages 107-118 | Received 21 Feb 1978, Published online: 30 Sep 2009

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Read on this site (3)

C. Palette, F. Dubor, V. Rovei & C. Advenier. (1993) Determination of antipyrine sulphoconjugates in isolated cultured rat hepatocytes. Xenobiotica 23:2, pages 181-191.
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Bruce Clark, Dennis A. Smith & John Caldwell. (1984) Pharmacokinetics and Toxicity Testing. CRC Critical Reviews in Toxicology 12:4, pages 343-385.
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Articles from other publishers (18)

Antonio Duenas-Laita, Michael G Barry, Padraic Mac Mathuna & John Feely. (1987) Effects of chronic treatment with amiodarone on hepatic demethylation and cytochrome P450. Journal of Pharmacy and Pharmacology 39:9, pages 757-759.
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B Chindavijak, F M Belpaire & M G Bogaert. (1987) In-vitro biotransformation of antipyrine, lignocaine and propranolol in the liver of rats with turpentine-induced inflammation. Journal of Pharmacy and Pharmacology 39:11, pages 883-886.
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G Taylor & J B Houston. (1985) Changes in the disposition of promethazine during multiple dosing in the rabbit. Journal of Pharmacy and Pharmacology 37:4, pages 243-247.
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T. C. Danbury, M. Eccles, J. Ford & C. J. Roberts. (1999) Effect of tacrine hydrochloride on hepatic drug metabolism. European Journal of Drug Metabolism and Pharmacokinetics 24:1, pages 91-96.
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I.C. Shaw. (1994) The use of in vitro methods for studying drug metabolism to replace animal studies as part of veterinary medicines product licence applications. Toxicology in Vitro 8:4, pages 917-919.
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K. S. Pang & M. Chiba. 1994. Pharmacokinetics of Drugs. Pharmacokinetics of Drugs 101 187 .
Luis A. Sainz-Pardo Clares & Ian C. Shaw. (2016) In Vitro Studies on the Metabolism of Antipyrine in the Pig and Rat: with Special Refierence to Veterinary Medicine Licensing. Human & Experimental Toxicology 12:6, pages 537-539.
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R. F. WITKAMP, S. M. NIJMEIJER, H.J. KOLKER, J. NOORDHOEK & A.S.J.P. A. M. VAN MIERT. (2008) Effect of gonadal hormones on the plasma clearance and metabolite formation of antipyrine in the dwarf goat. Journal of Veterinary Pharmacology and Therapeutics 16:2, pages 164-173.
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Gary P. Carlson & Robert W. Chadwick. (1987) Comparability of in vitro and in vivo methods for the determination of alterations in drug metabolism. Toxicology Letters 39:2-3, pages 125-138.
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A. Nakagawa, K. Nakamura, K. Maeda, T. Kamataki & R. Kato. (1987) Studies on antipyrine metabolism by 13C, 15N double labeled method. Life Sciences 41:2, pages 133-143.
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Robert W. Chadwick, M. Frank Copeland, Gary P. Carlson, Bruce A. Trela & Bernard M. Most. (1985) Comparison of in vivo and in vitro methods for assessing the effects of phenobarbital on the hepatic drug-metabolizing enzyme system. Toxicology Letters 29:2-3, pages 95-105.
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Rune Toftgård. (1983) Effects of xylene exposure on the metabolism of antipyrine in vitro and in vivo in the rat. Toxicology 28:1-2, pages 117-131.
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AR Boobis, MJ Brodie, GC Kahn, EL Toverud, IA Blair, S Murray & DS Davies. (2012) Comparison of the in vivo and in vitro rates of formation of the three main oxidative metabolites of antipyrine in man.. British Journal of Clinical Pharmacology 12:6, pages 771-777.
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G. Clare Kahn, Alan R. Boobis, Ian A. Blair, Martin J. Brodie & Donald S. Davies. (1981) A radiometric high-pressure liquid chromatography assay for the simultaneous determination of the three main oxidative metabolites of antipyrine in studies in vitro. Analytical Biochemistry 113:2, pages 292-300.
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E. Doyle & L.F. Chasseaud. (1981) Comparative pharmacokinetics of antipyrine (phenazone) in the baboon, cynomolgus monkey and rhesus monkey. Toxicology 19:2, pages 159-168.
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D.M. Chambers & G.C. Jefferson. (1981) Antipyrine estimations in the rabbit using gas-liquid chromatography: A reliable method for studying factors affecting oxidative drug metabolism. Journal of Pharmacological Methods 5:1, pages 59-66.
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Dominique Vuitton, J.P. Miguet, G. Camelot, Christiane Delafin, Christiane Joanne, P. Bechtel, M. Gillet & P. Carayon. (1981) Relationship between metabolic clearance rate of antipyrine and hepatic microsomal drug-oxidizing enzyme activities in humans without liver disease. Gastroenterology 80:1, pages 112-118.
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T. Høyem‐Johansen, L. Slerdal, A. Høylandskjær & J. Aarbakke. (2009) The Effect of Antineoplastic Drugs on the Pharmacokinetics of Antipyrine in the Rat. Acta Pharmacologica et Toxicologica 47:4, pages 279-284.
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