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Xenobiotica
the fate of foreign compounds in biological systems
Volume 9, 1979 - Issue 3
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Original Article

Metabolic fate of noscapine. II. Isolation and identification of novel metabolites produced by C—C bond cleavage

N. Tsunoda National Research Institute of Police Science, Tokyo, 102, Japan
&
H. Yoshimura Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, 812, Japan
Pages 181-187 | Received 02 Aug 1978, Published online: 30 Sep 2009

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Jayaprakasam Bolleddula & Swapan K. Chowdhury. (2015) Carbon–carbon bond cleavage and formation reactions in drug metabolism and the role of metabolic enzymes. Drug Metabolism Reviews 47:4, pages 534-557.
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N. Tsunoda & H. Yoshimura. (1981) Metabolic fate of noscapine.; III. Further studies on identification and determination of the metabolites. Xenobiotica 11:1, pages 23-32.
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Articles from other publishers (29)

Kuntal Manna, Waikhom Somraj Singh, Sanchari Goswami, Abu Md Ashif Ikbal, Amlanjyoti Rajkhowa & Bikash Debnath. (2023) Metabolites Study of Experimental Plant Derived Alkaloids: A Review. The Natural Products Journal 13:7.
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Alice Pavanello, Debora Fabbri, Paola Calza, Debora Battiston, Miguel A. Miranda & M. Luisa Marin. (2022) Biomimetic photooxidation of noscapine sensitized by a riboflavin derivative in water: The combined role of natural dyes and solar light in environmental remediation. Journal of Photochemistry and Photobiology B: Biology 229, pages 112415.
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Shalaka A. Shetge & Benjamin W. Redan. (2022) Assessment of Dry Heating, Water Rinsing, and Baking on Concentrations of the Opium Alkaloid Noscapine in Poppy Seeds. ACS Food Science & Technology 2:3, pages 541-547.
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B. Kaboudin & M. Sohrabi. (2021) Chemistry and synthesis of major opium alkaloids: a comprehensive review. Journal of the Iranian Chemical Society 18:12, pages 3177-3218.
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Mona El-Aasr, Duaa Eliwa, Mohamed Albadry, Abdel-Rahim S. Ibrahim, Amal Kabbash, Kumudini M. Meepagala, Ikhlas A. Khan, Shabana I. Khan & Samir A. Ross. (2021) Microbial transformation of some simple isoquinoline and benzylisoquinoline alkaloids and in vitro studies of their metabolites. Phytochemistry 189, pages 112828.
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Mahluga Jafarova Demirkapu & Hasan Raci Yananli. 2021. Bioactive Compounds in Nutraceutical and Functional Food for Good Human Health. Bioactive Compounds in Nutraceutical and Functional Food for Good Human Health.
María A. Oliva, Andrea E. Prota, Javier Rodríguez-Salarichs, Youssef L. Bennani, Jesús Jiménez-Barbero, Katja Bargsten, Ángeles Canales, Michel O. Steinmetz & J. Fernando Díaz. (2020) Structural Basis of Noscapine Activation for Tubulin Binding. Journal of Medicinal Chemistry 63:15, pages 8495-8501.
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Luke Richards, Adrian Lutz, David K. Chalmers, Ailsa Jarrold, Tim Bowser, Geoffrey W. Stevens & Sally L. Gras. (2019) Production of metabolites of the anti-cancer drug noscapine using a P450BM3 mutant library. Biotechnology Reports 24, pages e00372.
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Karel Nesměrák, Karel Kudláček, Martin Štícha, Petr Kozlík, Václav Červený & Jana Kunešová. (2019) Degradation of the opium alkaloids in pharmaceutical relics from the eighteenth century. Monatshefte für Chemie - Chemical Monthly 150:9, pages 1593-1602.
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Ruiqing Ni, Diana Rita Kindler, Rebecca Waag, Marie Rouault, Priyanka Ravikumar, Roger Nitsch, Markus Rudin, Giovanni G. Camici, Luca Liberale, Luka Kulic & Jan Klohs. (2019) fMRI Reveals Mitigation of Cerebrovascular Dysfunction by Bradykinin Receptors 1 and 2 Inhibitor Noscapine in a Mouse Model of Cerebral Amyloidosis. Frontiers in Aging Neuroscience 11.
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Bikash Debnath, Waikhom Somraj Singh, Manik Das, Sanchari Goswami, Mahesh Kumar Singh, Debasish Maiti & Kuntal Manna. (2018) Role of plant alkaloids on human health: A review of biological activities. Materials Today Chemistry 9, pages 56-72.
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Prem K. Gupta, Gary Barone, Bill J. Gurley, E. Kim Fifer & Howard P. Hendrickson. (2015) Hydrastine Pharmacokinetics and Metabolism after a Single Oral Dose of Goldenseal ( Hydrastis canadensis ) to Humans . Drug Metabolism and Disposition 43:4, pages 534-552.
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Mats O Karlsson & Bengt Dahlström. (1990) Serum protein binding of noscapine: Influence of a reversible hydrolysis. Journal of Pharmacy and Pharmacology 42:2, pages 140-143.
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Bokyung Sung, Kwang Seok Ahn & Bharat B. Aggarwal. (2010) Noscapine, a Benzylisoquinoline Alkaloid, Sensitizes Leukemic Cells to Chemotherapeutic Agents and Cytokines by Modulating the NF-κB Signaling Pathway. Cancer Research 70:8, pages 3259-3268.
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Ahmed Ashour, Maha Abdel Monem Hegazy, Azza Aziz Moustafa, Khadiga Omar Kelani & Laila Elsayed Abdel Fattah. (2009) Validated stability‐indicating TLC method for the determination of noscapine. Drug Testing and Analysis 1:7, pages 327-338.
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Babiker M. El-Haj, Abdelkader M. Al-Amri, Heyam S. Ali & Iqbal Ahmed. (2007) GC-MS detection and characterization of thebaine as a urinary marker of opium use. Forensic Toxicology 25:2, pages 62-68.
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Ritu Aneja, Neerupma Dhiman, Jyoti Idnani, Anshumali Awasthi, Sudershan K. Arora, Ramesh Chandra & Harish C. Joshi. (2007) Preclinical pharmacokinetics and bioavailability of noscapine, a tubulin-binding anticancer agent. Cancer Chemotherapy and Pharmacology 60:6, pages 831-839.
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Babiker M. El-Haj, Abdelkader M. Al-Amri & Heyam S. Ali. (2007) GC-MS detection and tentative characterization of two noscapine metabolites in human urine and their potential as markers for opium and illicit heroin use. Forensic Toxicology 25:1, pages 22-29.
Crossref
Keqiang Ye, Yong Ke, Nagalakshmi Keshava, John Shanks, Judith A. Kapp, Rajeshwar R. Tekmal, John Petros & Harish C. Joshi. (1998) Opium alkaloid noscapine is an antitumor agent that arrests metaphase and induces apoptosis in dividing cells. Proceedings of the National Academy of Sciences 95:4, pages 1601-1606.
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Daniel F. Chollet, Corinne Ruols & Valdo Arnera. (1997) Determination of noscapine in human plasma using solid-phase extraction and high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications 701:1, pages 81-85.
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A.G. Rauws, E.J. De Waal & J.W. Van Der Laan. 1997. Advances in Drug Research Volume 30. Advances in Drug Research Volume 30 15 72 .
F. von Bruchhausen, S. Ebel, E. Hackenthal, G. Dannhardt, A. W. Frahm, U. Holzgrabe, K. Keller, E. Nürnberg, H. Rimpler, G. Schneider, P. Surmann, H. U. Wolf & G. Wurm. 1993. Hagers Handbuch der Pharmazeutischen Praxis. Hagers Handbuch der Pharmazeutischen Praxis 1057 1220 .
M. O. Karlsson, B. Dahlstr�m, S.-�. Eckern�s, M. Johansson & A. Tufvesson Alm. (1990) Pharmacokinetics of oral noscapine. European Journal of Clinical Pharmacology 39:3, pages 275-279.
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Margareta Johansson, Agneta Tufvesson Alm, Heidi Forsmo-Bruce, Sven Jacobsson & Douglas Westerlund. (1988) Determination of noscapine and its metabolites in plasma by coupled-column liquid chromatography. Journal of Chromatography A 459, pages 301-311.
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Veikko Haikala. (1985) New sensitive method to determine noscapine in serum by reversed-phase liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications 337, pages 429-433.
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Karen Møller Jensen. (1983) Determination of noscapine in serum by high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications 274, pages 381-387.
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Margareta Johansson, Staffan Eksborg & Astrid Arbin. (1983) Determination of noscapine in plasma by liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications 275, pages 355-366.
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B. Dahlström, T. Mellstrand, C. -G. Löfdahl & M. Johansson. (1982) Pharmakokinetic properties of noscapine. European Journal of Clinical Pharmacology 22:6, pages 535-539.
Crossref
Jerome Edelson, David P. Benziger & James E. Peterson. 1981. Annual Reports in Medicinal Chemistry Volume 16. Annual Reports in Medicinal Chemistry Volume 16 319 327 .

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