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Xenobiotica
the fate of foreign compounds in biological systems
Volume 9, 1979 - Issue 5
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Original Article

Studies related to the metabolism of anabolic steroids in the horse: testosterone

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Pages 269-279 | Received 23 Oct 1978, Published online: 30 Sep 2009

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A. Schmitz, J. Zielinski, B. Dick & M. Mevissen. (2014) In vitro metabolism of testosterone in the horse liver and involvement of equine CYPs 3A89, 3A94 and 3A95 . Journal of Veterinary Pharmacology and Therapeutics 37:4, pages 338-347.
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B. C. MOELLER, R. A. SAMS, J. GUINJAB-CAGMAT, N. J. SZABO, P. COLAHAN & S. D. STANLEY. (2011) An interlaboratory study of the pharmacokinetics of testosterone following intramuscular administration to Thoroughbred horses. Journal of Veterinary Pharmacology and Therapeutics 34:6, pages 588-593.
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Jenny K. Y. Wong, Francis P. W. Tang & Terence S. M. Wan. (2011) In vitro metabolic studies using homogenized horse liver in place of horse liver microsomes. Drug Testing and Analysis 3:6, pages 393-399.
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James P. Scarth, Phil Teale & Tiia Kuuranne. (2011) Drug metabolism in the horse: a review. Drug Testing and Analysis 3:1, pages 19-53.
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Philip TealeEdward Houghton. (2010) Metabolism of anabolic steroids and their relevance to drug detection in horseracing. Bioanalysis 2:6, pages 1085-1107.
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Andrew R McKinney. (2009) Modern techniques for the determination of anabolic–androgenic steroid doping in the horse. Bioanalysis 1:4, pages 785-803.
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Ed Houghton & Steve Maynard. 2010. Doping in Sports. Doping in Sports 369 409 .
Philip B. Grace, Erica C. Drake, Philip Teale & Edward Houghton. (2008) Quantification of 19-nortestosterone sulphate and boldenone sulphate in urine from male horses using liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry 22:19, pages 2999-3007.
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L. R. SOMA, C. E. UBOH, F. GUAN, S. MCDONNELL & J. PACK. (2007) Pharmacokinetics of boldenone and stanozolol and the results of quantification of anabolic and androgenic steroids in race horses and nonrace horses. Journal of Veterinary Pharmacology and Therapeutics 30:2, pages 101-108.
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Andrew R. McKinney, Craig J. Suann & Allen M. Stenhouse. (2007) A stereochemical examination of the equine metabolism of 17α-methyltestosterone. Analytica Chimica Acta 581:2, pages 377-387.
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P. Anielski, D. Thieme, A. Schlupp, J. Grosse, F. Ellendorff & R. K. Mueller. (2005) Detection of testosterone, nandrolone and precursors in horse hair. Analytical and Bioanalytical Chemistry 383:6, pages 903-908.
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M. C. Dumasia. (2003) In vivo biotransformation of 17α‐methyltestosterone in the horse revisited: identification of 17‐hydroxymethyl metabolites in equine urine by capillary gas chromatography/mass spectrometry . Rapid Communications in Mass Spectrometry 17:4, pages 320-329.
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Andrew R. McKinney, Damon D. Ridley & Craig J. Suann. (2001) The metabolism of norethandrolone in the horse: characterization of 16-, 20- and 21-oxygenated metabolites by gas chromatography/mass spectrometry. Journal of Mass Spectrometry 36:2, pages 145-150.
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Karen A. Bean & Jack D. Henion. (1997) Direct determination of anabolic steroid conjugates in human urine by combined high-performance liquid chromatography and tandem mass spectrometry. Journal of Chromatography B: Biomedical Sciences and Applications 690:1-2, pages 65-75.
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R. Palme, P. Fischer, H. Schildorfer & M.N. Ismail. (1996) Excretion of infused 14C-steroid hormones via faeces and urine in domestic livestock. Animal Reproduction Science 43:1, pages 43-63.
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D. B. Gower, E. Houghton & A. T. Kicman. 1995. Steroid Analysis. Steroid Analysis 468 526 .
Claudia Schoene, Angus N. R. Nedderman & Edward Houghton. (1994) Preliminary study of the metabolism of 17α-methyltestosterone in horses utilizing gas chromatography–mass spectrometric techniques. The Analyst 119:12, pages 2537-2542.
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B. Le Bizec, M.-P. Montrade, F. Monteau & F. Andre. (1993) Detection and identification of anabolic steroids in bovine urine by gas chromatography—mass spectrometry. Analytica Chimica Acta 275:1-2, pages 123-133.
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E. Houghton, L. Grainger, M. C. Dumasia & P. Teale. (1992) Application of gas chromatography/mass spectrometry to steroid analysis in equine sports: Problems with enzyme hydrolysis. Organic Mass Spectrometry 27:10, pages 1061-1070.
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P. Teale & E. Houghton. (1991) The development of a gas chromatographic/mass spectrometric screening procedure to detect the administration of anabolic steroids to the horse. Biological Mass Spectrometry 20:3, pages 109-114.
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E. Houghton, M.C. Dumasia, P. Teale, S.J. Smith, J. Cox, D. MarshaII & D.B. Gower. (1990) The use of stable isotopes and gas chromatography/mass spectrometry in the identification of steroid metabolites in the equine. Steroids 55:10, pages 433-439.
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Ping W. Tang & David L. Crone. (1989) A new method for hydrolyzing sulfate and glucuronyl conjugates of steroids. Analytical Biochemistry 182:2, pages 289-294.
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M. C. Dumasia & E. Houghton. (1988) Biotransformation of 1-dehydrotestosterone in the equine male castrate: Identification of the neutral unconjugated and glucuronic acid conjugated metabolites in horse urine. Biological Mass Spectrometry 17:5, pages 383-392.
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E. Houghton, M.C. Dumasia, P. Teale, M.S. Moss & Sharon Sinkins. (1986) Development of a gas chromatographic—mass spectrometric method using multiple analytes for the confirmatory analysis of anabolic steroid residues in horse urine. Journal of Chromatography B: Biomedical Sciences and Applications 383, pages 1-8.
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Minoo C. Dumasia, Edward Houghton & Sharon Sinkins. (1986) Development of a gas chromatographic—mass spectrometric method using multiple analytes for the confirmatory analysis of anabolic steroids in horse urine. Journal of Chromatography B: Biomedical Sciences and Applications 377, pages 23-33.
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E. Houghton, J. Copsey, M. C. Dumasia, P. E. Haywood, M. S. Moss & P. Teale. (1984) The identification of C-18 neutral steroids in normal stallion urine. Biological Mass Spectrometry 11:2, pages 96-99.
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M. C. Dumasia, E. Houghton, Carol V. Bradley & D. H. Williams. (1983) Studies related to the metabolism of anabolic steriods in the horse: The metabolism of 1-dehydrotestosterone and the use of fast atom bombardment mass spectrometry in the identification of steroid conjugates. Biological Mass Spectrometry 10:7, pages 434-440.
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