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Xenobiotica
the fate of foreign compounds in biological systems
Volume 9, 1979 - Issue 7
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Original Article

Metabolism of 8-chloro-6-(o-chlorophenyl)-1-methyl-4H-s-triazolo [4,3-a] [1,4]benzodiazepine, triazolam, a new central depressant. II. Identification and determination of metabolites in rats and dogs

H. Kitagawa Department of Biochemical Pharmacology, Faculty of Pharmaceutical Sciences, Chiba University, 1-33, Yayoicho, Chiba, 280, Japan
,
Y. Esumi Tokai Laboratories, Daiichi Pure Chemicals Co., Ltd., Tokaimura, Nakagun, Ibaragi, 319-11, Japan
,
S. Kurosawa Tokai Laboratories, Daiichi Pure Chemicals Co., Ltd., Tokaimura, Nakagun, Ibaragi, 319-11, Japan
,
S. Sekine Tokai Laboratories, Daiichi Pure Chemicals Co., Ltd., Tokaimura, Nakagun, Ibaragi, 319-11, Japan
&
T. Yokoshima Tokai Laboratories, Daiichi Pure Chemicals Co., Ltd., Tokaimura, Nakagun, Ibaragi, 319-11, Japan
Pages 429-439 | Received 16 Dec 1977, Published online: 30 Sep 2009

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H. M. Jones, G. Nicholls & J. B. Houston. (2005) Impact of end-product inhibition on the determination of in vitro metabolic clearance. Xenobiotica 35:5, pages 439-454.
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H. P. A. Illing, C. D. Bevan, J. D. Robinson, J. Chamberlain & J. M. Fromson. (1983) Metabolism of loprazolam in rat, dog and man in vivo. Xenobiotica 13:9, pages 539-553.
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Grace K. Woo, T. H. Williams, S. J. Kolis, Dolores Warinsky, G. J. Sasso & M. A. Schwartz. (1981) Biotransformation of [14C]midazolam in the rat in vitro and in vivo. Xenobiotica 11:6, pages 373-384.
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Articles from other publishers (12)

F. Yous, D. Atmani-Kilani, N. Debbache-Benaida, N. Cheraft, S. Sebaihi, N. Saidene, M. Benloukil & D. Atmani. (2018) Anti-ulcerogenic and proton pump (H+, K+ ATPase) inhibitory activity of Clematis flammula L. extract. South African Journal of Botany 119, pages 390-399.
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Hideo Shiota, Mikiro Nakashima, Hideyuki Terazono, Hitoshi Sasaki, Koyo Nishida, Junzo Nakamura & Kotaro Taniyama. (2004) Postmortem changes in tissue concentrations of triazolam and diazepam in rats. Legal Medicine 6:4, pages 224-232.
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Kenichiro Nakashima, Kazumi Yamamoto, Osama Y. Al‐Dirbashi & Mihoko N. Nakashima. (2002) Disposition of triazolam in the rat by brain microdialysis and semi‐micro column high‐performance liquid chromatography with UV absorbance detection. Biomedical Chromatography 16:3, pages 219-223.
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H. Schütz. 1997. Analytical Toxicology for Clinical, Forensic and Pharmaceutical Chemists. Analytical Toxicology for Clinical, Forensic and Pharmaceutical Chemists 369 398 .
Jacques Gaudreault, France Varin & Gary M. Pollack. (1996) Anticonvulsant Pharmacodynamics and Disposition of Triazolam in Rats††These results were presented, in part, at the Seventh Annual Meeting of the American Association of Pharmaceutical Scientists, San Antonio, TX, November 1992.. Journal of Pharmaceutical Sciences 85:9, pages 999-1004.
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Michel Bottlaender, Emmanuel Brouillet, Marina Varastet, Christine Le Breton, Lorenz Schmid, Chantal Fuseau, René Sitbon, Christian Crouzel & Mariannick Mazière. (2008) In Vivo High Intrinsic Efficacy of Triazolam: A Positron Emission Tomography Study in Nonhuman Primates. Journal of Neurochemistry 62:3, pages 1102-1111.
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J.E.C. Burnett, J.S. Oliver & H. Smith. (1989) Radioreceptor assay and radioimmunoassay of triazolam in urine samples from racing greyhounds. Forensic Science International 43:2, pages 199-205.
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T. Mennini, S. Caccia & S. Garattini. 1987. Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrès des recherches pharmaceutiques. Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrès des recherches pharmaceutiques 315 347 .
Thomas Roth, Timothy A. Roehrs & Frank J. Zorick. (2012) Pharmacology and Hypnotic Efficacy of Triazolam. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 3:3, pages 137-145.
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Masaharu Konishi, Yoshio Mori & Kentaro Hirai. (1982) Simultaneous determination of triazolo-benzophenone [2′,5-dichloro-2-(3-glycylaminomethyl-5-methyl-4H-1,2,4-triazol-4-yl)-benzophenone] and its major blood metabolite, triazolam, in monkey plasma by electron-capture gas—liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications 229:2, pages 355-363.
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Richard S. P. Hsi & Wayne T. Stolle. (2006) Synthesis of carbon‐14 labeled 1,4‐benzodiazepines. IV. Carbon‐13 and carbon‐14 labeled 8‐chloro‐1‐(2‐dimethylamino)ethyl‐6‐phenyl‐4H‐ s ‐triazolo[4,3‐a][1,4]‐benzodiazepine tosylate . Journal of Labelled Compounds and Radiopharmaceuticals 18:6, pages 881-888.
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Masaru Kusaka, Akiko Horikawa, Teruhiko Meshi & Yuji Maruyama. (1980) Interaction of triazolam with desipramine. Psychopharmacology 70:3, pages 255-261.
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