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Xenobiotica
the fate of foreign compounds in biological systems
Volume 9, 1979 - Issue 9
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Original Article

Metabolic Studies of Ornidazole in the Rat, in the Dog and in Man

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Pages 571-581 | Received 14 Nov 1978, Published online: 30 Sep 2009

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Guangyi Yang, Shufan Ge, Rashim Singh, Sumit Basu, Katherine Shatzer, Ming Zen, Jiong Liu, Yifan Tu, Chenning Zhang, Jinbao Wei, Jian Shi, Lijun Zhu, Zhongqiu Liu, Yuan Wang, Song Gao & Ming Hu. (2017) Glucuronidation: driving factors and their impact on glucuronide disposition. Drug Metabolism Reviews 49:2, pages 105-138.
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Gerald L. Kennedy & Robert D. Short. (1986) Biological Effects of Acetamide, Formamide, and Their Monomethyl and Dimethyl Derivatives. CRC Critical Reviews in Toxicology 17:2, pages 129-182.
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Bruce Clark, Dennis A. Smith & John Caldwell. (1984) Pharmacokinetics and Toxicity Testing. CRC Critical Reviews in Toxicology 12:4, pages 343-385.
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Articles from other publishers (33)

Sichan Li, Ming Cao, Yan Zhou, Chang Shu & Yang Wang. (2023) Ornidazole Transfer into Colostrum and Assessment of Exposure Risk for Breastfeeding Infant: A Population Pharmacokinetic Analysis. Pharmaceutics 15:11, pages 2524.
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Shuai Wang, Shuguang Ma, Eugene Chen, Jing Wang, Hoa Le, Steven Paul Hanlon, Martin Binder, Wendy Lee, S. Cyrus Khojasteh & Laurent Salphati. (2023) Mass Balance of the Indoleamine 2,3‐Dioxygenase Inhibitor Navoximod (GDC-0919) in Rats and Dogs: Unexpected Cyanide Release from Imidazo[5,1- a ]isoindole and Species Differences in Glucuronidation . Drug Metabolism and Disposition 51:7, pages 862-872.
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Gaoli He, Beining Guo, Jing Zhang, Yi Li, Xiaojie Wu, Yaxin Fan, Yuancheng Chen, Guoying Cao & Jicheng Yu. (2018) Determination of the sulfate and glucuronide conjugates of levornidazole in human plasma and urine, and levornidazole and its five metabolites in human feces by high performance liquid chromatography–tandem mass spectrometry. Journal of Chromatography B 1081-1082, pages 87-100.
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Beining Guo, Gaoli He, Xiaojie Wu, Jicheng Yu, Guoying Cao, Yi Li, Yaxin Fan, Yuancheng Chen, Yaoguo Shi, Yingyuan Zhang & Jing Zhang. (2017) Clinical Pharmacokinetics of Levornidazole in Elderly Subjects and Dosing Regimen Evaluation Using Pharmacokinetic/Pharmacodynamic Analysis. Clinical Therapeutics 39:7, pages 1336-1346.
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Y. Liao, T. J. Williams, J. C. Walsh, M. Ji, A. Poljak, P. M. G. Curmi, I. G. Duggin & R. Cavicchioli. (2016) Developing a genetic manipulation system for the Antarctic archaeon, Halorubrum lacusprofundi: investigating acetamidase gene function. Scientific Reports 6:1.
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Yuran Cao, Xiaojie Wu, Yuancheng Chen, Beining Guo, Jicheng Yu, Guoying Cao, Jing Zhang, Yaoguo Shi & Yingyuan Zhang. (2016) Improved pharmacokinetic profile of levornidazole following intravenous infusion of 750mg every 24h compared with 500mg every 12h in healthy Chinese volunteers. International Journal of Antimicrobial Agents 47:3, pages 224-228.
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Adeola O Adebisi & Barbara R Conway. (2015) Modification of drug delivery to improve antibiotic targeting to the stomach. Therapeutic Delivery 6:6, pages 741-762.
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Jiali Hu, Jing Zhang, Shi Wu, Demei Zhu, Haihui Huang, Yuancheng Chen, Yang Yang & Yingyuan Zhang. (2014) Evaluation of the in vitro activity of levornidazole, its metabolites and comparators against clinical anaerobic bacteria. International Journal of Antimicrobial Agents 44:6, pages 514-519.
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Yuran Cao, Miao Zhao, Xiaojie Wu, Beining Guo, Yuancheng Chen, Jicheng Yu, Guoying Cao, Jing Zhang, Yaoguo Shi & Yingyuan Zhang. (2014) Quantification of levornidazole and its metabolites in human plasma and urine by ultra-performance liquid chromatography–mass spectrometry. Journal of Chromatography B 963, pages 119-127.
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Jiangbo Du. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 2 .
Jiangbo Du, Tiangeng You, Xiaoyan Chen & Dafang Zhong. (2013) Stereoselective Glucuronidation of Ornidazole in Humans: Predominant Contribution of UDP-Glucuronosyltransferases 1A9 and 2B7. Drug Metabolism and Disposition 41:7, pages 1306-1318.
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Alessio Soggiu, Cristian Piras, Hany Ahmed Hussein, Michele De Canio, Alessandro Gaviraghi, Andrea Galli, Andrea Urbani, Luigi Bonizzi & Paola Roncada. (2013) Unravelling the bull fertility proteome. Molecular BioSystems 9:6, pages 1188.
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Jiangbo Du, Pan Deng, Xiaoyan Chen, Haidong Wang, Tiangeng You & Dafang Zhong. (2012) Characterization of ornidazole metabolites in human bile after intraveneous doses by ultraperformance liquid chromatography/quadrupole time-of-flight mass spectrometry. Acta Pharmaceutica Sinica B 2:2, pages 159-167.
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Y. Shravan Kumar, S. Ramesh, Y. Madhusudan Rao & A.R. Paradkar. (2007) EFFECT OF RIFAMPICIN PRETREATMENT ON THE TRANSPORT ACROSS RAT INTESTINE AND ORAL PHARMACOKINETICS OF ORNIDAZOLE IN HEALTHY HUMAN VOLUNTEERS. Drug Metabolism and Drug Interactions 22:2-3.
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Jianquan Huang, Guoying Cao, Xin Hu, Chunhua Sun & Junren Zhang. (2006) Chiral separation ofrac-Ornidazole and detection of the impurity of (R)-Ornidazole in (S)-Ornidazole injection and raw material. Chirality 18:8, pages 587-591.
Crossref
Ping Tian, Jia-Shi Peng, Zu-Yi Li & Guo-Qiang Lin. (2010) Lipase-Catalyzed Resolutions of both Enantiomers of Ornidazole and Secnidazole. Chinese Journal of Chemistry 21:7, pages 853-857.
Crossref
Paramjeet Singh, Rohit Mittal, G.C. Sharma, Sukhjeet Singh & Amarjit Singh. 2003. 123 184 .
W. Bone, A. R Jones & T. G. Cooper. (2002) The effect of (R,S)-ornidazole on the fertility of male mice and the excretion and metabolism of 36Cl-(R,S)-ornidazole and 36Cl-(R,S)-alpha-chlorohydrin in male mice and rats. International Journal of Andrology 25:2, pages 94-99.
Crossref
JONES & COOPER. (2001) A re‐appraisal of the post‐testicular action and toxicity of chlorinated antifertility compounds. International Journal of Andrology 22:3, pages 130-138.
Crossref
TREVOR G. COOPER, CHING‐HEI YEUNG, ROLF SKUPIN & GÜNTER HAUFE. (2013) Antifertility Potential of Ornidazole Analogues in Rats. Journal of Andrology 18:4, pages 431-438.
Crossref
Rolf Skupin, Trevor G. Cooper, Roland Fr?hlich, J?rg Prigge & G?nter Haufe. (1997) Lipase-catalyzed resolution of both enantiomers of Ornidazole and some analogues. Tetrahedron: Asymmetry 8:14, pages 2453-2464.
Crossref
David J. Lythgoe & Christopher A. Ramsden. 1994. Advances in Heterocyclic Chemistry Volume 61. Advances in Heterocyclic Chemistry Volume 61 1 58 .
F. von Bruchhausen, S. Ebel, E. Hackenthal, G. Dannhardt, A. W. Frahm, U. Holzgrabe, K. Keller, E. Nürnberg, H. Rimpler, G. Schneider, P. Surmann, H. U. Wolf & G. Wurm. 1993. Hagers Handbuch der Pharmazeutischen Praxis. Hagers Handbuch der Pharmazeutischen Praxis 1221 1293 .
P. Heizmann, R. Geschke & K. Zinapold. (1990) Determination of ornidazole and its main metabolites in biological fluids. Journal of Chromatography B: Biomedical Sciences and Applications 534, pages 233-240.
Crossref
F. F. Horber, O. Maurer, P. J. Probst, E. Heizmann & F. J. Frey. (1989) High haemodialysis clearance of ornidazole in the presence of a negligible renal clearance. European Journal of Clinical Pharmacology 36:4, pages 389-393.
Crossref
A. Barrow, S. R. Burford, T. J. Forrest, A. J. Hawkins, D. A. Rose, P. M. Stevens, C. W. Vose & C. M. Walls. (1987) Studies on the disposition of a 5-nitroimidazole in laboratory animals. European Journal of Drug Metabolism and Pharmacokinetics 12:2, pages 85-90.
Crossref
A. Groppi, P. Papa, M. Montagna & G. Carosi. (1986) Determination of ornidazole in human plasma and red blood cells using high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications 380, pages 437-442.
Crossref
H Merdjan, A Baumelou, B Diquet, O Chick & E Singlas. (2012) Pharmacokinetics of ornidazole in patients with renal insufficiency; influence of haemodialysis and peritoneal dialysis.. British Journal of Clinical Pharmacology 19:2, pages 211-217.
Crossref
YIN-TAK WOO, DAVID Y. LAI, JOSEPH C. ARCOS & MARY F. ARGUS. 1985. Aliphatic and Polyhalogenated Carcinogens. Aliphatic and Polyhalogenated Carcinogens 3 414 .
H.R. Rabin & D.L. Lockerby. 1984. Antimicrobial Drug Resistance. Antimicrobial Drug Resistance 317 344 .
Richard J. Knox, Richard C. Knight & David I. Edwards. (1983) Studies on the action of nitroimidazole drugs. Biochemical Pharmacology 32:14, pages 2149-2156.
Crossref
H. Merdjan, C. Bonnat, E. Singlas & B. Diquet. (1983) Measurement of ornidazole by high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications 273:2, pages 475-480.
Crossref
C.E. Voogd. (1981) On the mutagenicity of nitroimidazoles. Mutation Research/Reviews in Genetic Toxicology 86:3, pages 243-277.
Crossref

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