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S. Uno, A. Fujii, H. Komura, A. Kawase & M. Iwaki. (2008) Prediction of metabolic clearance of diclofenac in adjuvant-induced arthritis rats using a substrate depletion assay. Xenobiotica 38:5, pages 482-495.
Read now
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Wei Tang. (2007) Drug metabolite profiling and elucidation of drug-induced hepatotoxicity. Expert Opinion on Drug Metabolism & Toxicology 3:3, pages 407-420.
Read now
Read now
Peter H. Degen, Walter Dieterle, Werner Schneider, Walter Theobald & Ursula Sinterhauf. (1988) Pharmacokinetics of Diclofenac and Five Metabolites After Single Doses in Healthy Volunteers and After Repeated Doses in Patients. Xenobiotica 18:12, pages 1449-1455.
Read now
Read now
Johann W. Faigle, Irmgard BÖttcher, Jacques Godbillon, Hans P. Kriemler, Erich Schlumpf, Werner Schneider, Alfred Schweizer, Hiltrud Stierlin & Tammo Winkler. (1988) A New Metabolite of Diclofenac Sodium in Human Plasma. Xenobiotica 18:10, pages 1191-1197.
Read now
Read now
K. Brune, K. Dietzel, B. Nürnberg & H. -Th. Schneider. (1987) Recent Insight into the Mechanism of Gastrointestinal Tract Ulceration. Scandinavian Journal of Rheumatology 16:sup65, pages 135-140.
Read now
Read now
Ellen M. Faed. (1984) Properties of Acyl Glucuronides: Implications for Studies of the Pharmacokinetics and Metabolism of Acidic Drugs. Drug Metabolism Reviews 15:5-6, pages 1213-1249.
Read now
Read now
D. Greenslade, M. E. Havler, M. J. Humphrey, B. J. Jordan & M. J. Rance. (1980) Species differences in the metabolism and excretion of fenclofenac. Xenobiotica 10:10, pages 753-760.
Read now
Read now
H. Stierlin, J. W. Faigle, A. Sallmann, W. Kung, W. J. Richter, H.-P. Kriemler, K. O. Alt & T. Winkler. (1979) Biotransformation of diclofenac sodium (Voltaren®) in animals and in man. Xenobiotica 9:10, pages 601-610.
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Articles from other publishers (87)
Tuyen Van Nguyen, Adam Bořík, Jaylen L. Sims, Antonín Kouba, Vladimír Žlábek & Anna Koubová. (2023) Toxicological effects of diclofenac on signal crayfish (Pacifastacus leniusculus) as related to weakly acidic and basic water pH. Aquatic Toxicology 265, pages 106777.
Crossref
Crossref
Ivan Liakh, Darya Harshkova, Pavel Hrouzek, Kateřina Bišová, Anna Aksmann & Bartosz Wielgomas. (2023) Green alga Chlamydomonas reinhardtii can effectively remove diclofenac from the water environment – A new perspective on biotransformation. Journal of Hazardous Materials 455, pages 131570.
Crossref
Crossref
Lucie Bouly, Hélène Fenet, Jean-Luc Carayon, Elena Gomez, Florence Géret & Frédérique Courant. (2022) Metabolism of the aquatic pollutant diclofenac in the Lymnaea stagnalis freshwater gastropod. Environmental Science and Pollution Research 29:56, pages 85081-85094.
Crossref
Crossref
Huma Ilyas & Eric D. van Hullebusch. (2020) Performance comparison of different types of constructed wetlands for the removal of pharmaceuticals and their transformation products: a review. Environmental Science and Pollution Research 27:13, pages 14342-14364.
Crossref
Crossref
Yasser AlbadranyAhmed Naser. (2020) Coenzyme Q10 coadministration with diclofenac augmented impaired renal function in broiler chickens (Gallus gallus domesticus). Veterinary World 13:4, pages 642-648.
Crossref
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Palanivel Sathishkumar, Ramakrishnan Anu Alias Meena, Thavamani Palanisami, Veeramuthu Ashokkumar, Thayumanavan Palvannan & Feng Long Gu. (2020) Occurrence, interactive effects and ecological risk of diclofenac in environmental compartments and biota - a review. Science of The Total Environment 698, pages 134057.
Crossref
Crossref
Renato J. Scialis, Lauren M. Aleksunes, Iván L. Csanaky, Curtis D. Klaassen & José E. Manautou. (2019) Identification and Characterization of Efflux Transporters That Modulate the Subtoxic Disposition of Diclofenac and Its Metabolites. Drug Metabolism and Disposition 47:10, pages 1080-1092.
Crossref
Crossref
Muthusamy Ramesh & Prasad V. Bharatam. (2019) Formation of a Toxic Quinoneimine Metabolite from Diclofenac: A Quantum Chemical Study. Drug Metabolism Letters 13:1, pages 64-76.
Crossref
Crossref
Mary Kay McLean & Safdar A. Khan. (2018) Toxicology of Frequently Encountered Nonsteroidal Anti-inflammatory Drugs in Dogs and Cats. Veterinary Clinics of North America: Small Animal Practice 48:6, pages 969-984.
Crossref
Crossref
İlker Öngüç Aycan, Özlem Elpek, Bahar Akkaya, Ebru Kıraç, Hazal Tuzcu, Sabriye Kaya, Nesil Coşkunfırat & Mutay Aslan. (2018) Diclofenac induced gastrointestinal and renal toxicity is alleviated by thymoquinone treatment. Food and Chemical Toxicology 118, pages 795-804.
Crossref
Crossref
C. E. Wilson, A. P. Dickie, K. Schreiter, R. Wehr, E. M. Wilson, J. Bial, N. Scheer, I. D. Wilson & R. J. Riley. (2018) The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice. Archives of Toxicology 92:6, pages 1953-1967.
Crossref
Crossref
Katarzyna E. Lazarska, Stefan J. Dekker, Nico P.E. Vermeulen & Jan N.M. Commandeur. (2018) Effect of UGT2B7*2 and CYP2C8*4 polymorphisms on diclofenac metabolism. Toxicology Letters 284, pages 70-78.
Crossref
Crossref
Fabio Polesel, Elena Torresi, Luca Loreggian, Mònica Escolà Casas, Magnus Christensson, Kai Bester & Benedek Gy. Plósz. (2017) Removal of pharmaceuticals in pre-denitrifying MBBR – Influence of organic substrate availability in single- and three-stage configurations. Water Research 123, pages 408-419.
Crossref
Crossref
Bénilde Bonnefille, Lauren Arpin-Pont, Elena Gomez, Hélène Fenet & Frédérique Courant. (2017) Metabolic profiling identification of metabolites formed in Mediterranean mussels ( Mytilus galloprovincialis ) after diclofenac exposure. Science of The Total Environment 583, pages 257-268.
Crossref
Crossref
Y. Zhang, Y.-H. Han, S. P. Putluru, M. K. Matta, P. Kole, S. Mandlekar, M. T. Furlong, T. Liu, R. A. Iyer, P. Marathe, Z. Yang, Y. Lai & A. D. Rodrigues. (2015) Diclofenac and Its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro. Drug Metabolism and Disposition 44:3, pages 320-328.
Crossref
Crossref
María Hijosa-Valsero, Carolina Reyes-Contreras, Carmen Domínguez, Eloy Bécares & Josep M. Bayona. (2016) Behaviour of pharmaceuticals and personal care products in constructed wetland compartments: Influent, effluent, pore water, substrate and plant roots. Chemosphere 145, pages 508-517.
Crossref
Crossref
Simon T.K. Yauw, Roger M.L.M. Lomme, Rozemarijn J. van der Vijver, Thijs Hendriks, Kees J.H.M. van Laarhoven & Harry van Goor. (2015) Diclofenac causes anastomotic leakage in the proximal colon but not in the distal colon of the rat. The American Journal of Surgery 210:2, pages 382-388.
Crossref
Crossref
Hidetaka Kamimura, Satoshi Ito, Kohei Nozawa, Shota Nakamura, Hiroyuki Chijiwa, Shin-ichiro Nagatsuka, Miyuki Kuronuma, Yasuyuki Ohnishi, Hiroshi Suemizu & Shin-ichi Ninomiya. (2015) Formation of the Accumulative Human Metabolite and Human-Specific Glutathione Conjugate of Diclofenac in TK-NOG Chimeric Mice with Humanized Livers. Drug Metabolism and Disposition 43:3, pages 309-316.
Crossref
Crossref
Philipp Uhl, Gert Fricker, Uwe Haberkorn & Walter Mier. (2015) Radionuclides in drug development. Drug Discovery Today 20:2, pages 198-208.
Crossref
Crossref
ChanWoo Park, MyoungCheol Shin, JunYeol Lee, JunHwi Cho, TaekGeun Ohk & HuiYoung Lee. (2015) Single intramuscular injection of diclofenac sodium in febrile pediatric patients. Indian Journal of Pharmacology 47:3, pages 275.
Crossref
Crossref
Mohamed ELBADAWY, Takara SAKIYAMA, Rania ABOHATAB, Kazuaki SASAKI & Minoru SHIMODA. (2015) Oral pharmacokinetics of the acidic drugs, diclofenac and sulfamonomethoxine in male Shiba goats. Journal of Veterinary Medical Science 77:1, pages 21-26.
Crossref
Crossref
Thomas G. Hammond, Xiaoli Meng, Rosalind E. Jenkins, James L. Maggs, Anahi Santoyo Castelazo, Sophie L. Regan, Stuart N. L. Bennett, Caroline J. Earnshaw, Guruprasad P. Aithal, Ira Pande, J. Gerry Kenna, Andrew V. Stachulski, B. Kevin Park & Dominic P. Williams. (2014) Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from a Drug Acyl Glucuronide Metabolite: Multiple Albumin Adductions in Diclofenac Patients. Journal of Pharmacology and Experimental Therapeutics 350:2, pages 387-402.
Crossref
Crossref
Niina Vieno & Mika Sillanpää. (2014) Fate of diclofenac in municipal wastewater treatment plant — A review. Environment International 69, pages 28-39.
Crossref
Crossref
Thomas J. Bateman, Vijay G.B. Reddy, Masakazu Kakuni, Yoshio Morikawa & Sanjeev Kumar. (2014) Application of Chimeric Mice with Humanized Liver for Study of Human-Specific Drug Metabolism. Drug Metabolism and Disposition 42:6, pages 1055-1065.
Crossref
Crossref
R. Scott Obach. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics
1
41
.
Yoshihiro Shibata, Jiro Kuze & Masato Chiba. (2014) Utility of Cryopreserved Hepatocytes Suspended in Serum to Predict Hepatic Clearance in Dogs and Monkeys. Drug Metabolism and Pharmacokinetics 29:2, pages 168-176.
Crossref
Crossref
Jan Simon Boerma, Nico P.E. Vermeulen & Jan N.M. Commandeur. (2014) One-electron oxidation of diclofenac by human cytochrome P450s as a potential bioactivation mechanism for formation of 2′-(glutathion-S-yl)-deschloro-diclofenac. Chemico-Biological Interactions 207, pages 32-40.
Crossref
Crossref
Susanne Ramm & Angela Mally. (2013) Role of drug-independent stress factors in liver injury associated with diclofenac intake. Toxicology 312, pages 83-96.
Crossref
Crossref
Ken Grime & Stuart W. Paine. (2013) Species Differences in Biliary Clearance and Possible Relevance of Hepatic Uptake and Efflux Transporters Involvement. Drug Metabolism and Disposition 41:2, pages 372-378.
Crossref
Crossref
Jan Simon Boerma, Sanja Dragovic, Nico P. E. Vermeulen & Jan N. M. Commandeur. (2012)
Mass Spectrometric Characterization of Protein Adducts of Multiple P450-Dependent Reactive Intermediates of Diclofenac to Human Glutathione-
S
-transferase P1-1
. Chemical Research in Toxicology 25:11, pages 2532-2541.
Crossref
Crossref
Malin Darnell, Maria Ulvestad, Ewa Ellis, Lars Weidolf & Tommy B. Andersson. (2012) In Vitro Evaluation of Major In Vivo Drug Metabolic Pathways Using Primary Human Hepatocytes and HepaRG Cells in Suspension and a Dynamic Three-Dimensional Bioreactor System. Journal of Pharmacology and Experimental Therapeutics 343:1, pages 134-144.
Crossref
Crossref
Fumihiro Nakamori, Yoichi Naritomi, Ken-ichi Hosoya, Hiroyuki Moriguchi, Kazuhiro Tetsuka, Takako Furukawa, Keitaro Kadono, Katsuhiro Yamano, Shigeyuki Terashita & Toshio Teramura. (2012) Quantitative Prediction of Human Intestinal Glucuronidation Effects on Intestinal Availability of UDP-Glucuronosyltransferase Substrates Using In Vitro Data. Drug Metabolism and Disposition 40:9, pages 1771-1777.
Crossref
Crossref
Andrew A. Somogyi & Janet K. Coller. 2012. Metabolism of Drugs and Other Xenobiotics. Metabolism of Drugs and Other Xenobiotics
403
428
.
Hao Bao, Yan Ge, Shougang Zhuang, Lance D. Dworkin, Zhihong Liu & Rujun Gong. (2012) Inhibition of glycogen synthase kinase-3β prevents NSAID-induced acute kidney injury. Kidney International 81:7, pages 662-673.
Crossref
Crossref
Daniel Mueller, Ursula Müller-Vieira, Klaus M. Biemel, Georg Tascher, Andreas K. Nüssler & Fozia Noor. (2012) Biotransformation of diclofenac and effects on the metabolome of primary human hepatocytes upon repeated dose exposure. European Journal of Pharmaceutical Sciences 45:5, pages 716-724.
Crossref
Crossref
Helene Faber, Daniel Melles, Christine Brauckmann, Christoph Alexander Wehe, Kristina Wentker & Uwe Karst. (2012) Simulation of the oxidative metabolism of diclofenac by electrochemistry/(liquid chromatography/)mass spectrometry. Analytical and Bioanalytical Chemistry 403:2, pages 345-354.
Crossref
Crossref
Safdar A. Khan & Mary Kay McLean. (2012) Toxicology of Frequently Encountered Nonsteroidal Anti-Inflammatory Drugs in Dogs and Cats. Veterinary Clinics of North America: Small Animal Practice 42:2, pages 289-306.
Crossref
Crossref
Sophie L. Regan, James L. Maggs, Thomas G. Hammond, Craig Lambert, Dominic P. Williams & B. Kevin Park. (2010) Acyl glucuronides: the good, the bad and the ugly. Biopharmaceutics & Drug Disposition 31:7, pages 367-395.
Crossref
Crossref
Takayuki Hata, Shingo Kawai, Hideo Okamura & Tomoaki Nishida. (2010) Removal of diclofenac and mefenamic acid by the white rot fungus Phanerochaete sordida YK-624 and identification of their metabolites after fungal transformation. Biodegradation 21:5, pages 681-689.
Crossref
Crossref
Jesper Svanfelt, Jenny-Maria Kallio, Johan Eriksson & Leif Kronberg. 2010. Contaminants of Emerging Concern in the Environment: Ecological and Human Health Considerations. Contaminants of Emerging Concern in the Environment: Ecological and Human Health Considerations
243
255
.
Jamie E. Prior, Touraj Shokati, Uwe Christians & Ryan T. Gill. (2009) Identification and characterization of a bacterial cytochrome P450 for the metabolism of diclofenac. Applied Microbiology and Biotechnology 85:3, pages 625-633.
Crossref
Crossref
Kentarou Ushijima, Shu-ichi Tsuruoka, Hidetoshi Tsuda, Gohki Hasegawa, Yuri Obi, Tae Kaneda, Masaki Takahashi, Tomohiro Maekawa, Tomohiro Sasaki, Taka-aki Koshimizu & Akio Fujimura. (2009) Cranberry juice suppressed the diclofenac metabolism by human liver microsomes, but not in healthy human subjects. British Journal of Clinical Pharmacology 68:2, pages 194-200.
Crossref
Crossref
Makiko Kusama, Kazuya Maeda, Koji Chiba, Akinori Aoyama & Yuichi Sugiyama. (2008) Prediction of the Effects of Genetic Polymorphism on the Pharmacokinetics of CYP2C9 Substrates from In Vitro Data. Pharmaceutical Research 26:4, pages 822-835.
Crossref
Crossref
Sandra Pérez & Damià Barceló. (2008) First Evidence for Occurrence of Hydroxylated Human Metabolites of Diclofenac and Aceclofenac in Wastewater Using QqLIT-MS and QqTOF-MS. Analytical Chemistry 80:21, pages 8135-8145.
Crossref
Crossref
Dele Stülten, Marc Lamshöft, Sebastian Zühlke & Michael Spiteller. (2008) Isolation and characterization of a new human urinary metabolite of diclofenac applying LC–NMR–MS and high-resolution mass analyses. Journal of Pharmaceutical and Biomedical Analysis 47:2, pages 371-376.
Crossref
Crossref
A.C. Johnson, V. Keller, R.J. Williams & A. Young. (2007) A practical demonstration in modelling diclofenac and propranolol river water concentrations using a GIS hydrology model in a rural UK catchment. Environmental Pollution 146:1, pages 155-165.
Crossref
Crossref
Ann K. Daly, Guruprasad P. Aithal, Julian B.S. Leathart, Richard A. Swainsbury, Tarana Singh Dang & Christopher P. Day. (2007) Genetic Susceptibility to Diclofenac-Induced Hepatotoxicity: Contribution of UGT2B7, CYP2C8, and ABCC2 Genotypes. Gastroenterology 132:1, pages 272-281.
Crossref
Crossref
Thomayant Prueksaritanont, Chunze Li, Cuyue Tang, Yuhsin Kuo, Kristie Strong-Basalyga & Brian Carr. (2006) Rifampin Induces the in Vitro Oxidative Metabolism, but Not the in Vivo Clearance of Diclofenac in Rhesus Monkeys. Drug Metabolism and Disposition 34:11, pages 1806-1810.
Crossref
Crossref
Abdulla Y Altaher, Khalid M Alkharfy, Badraddin M Al-Hadiya & Rao Muzaffar A Khan. (2006) Pharmacokinetics of diclofenac in sheep following intravenous and intramuscular administration. Veterinary Anaesthesia and Analgesia 33:4, pages 241-245.
Crossref
Crossref
Lata Kaphalia, Bhupendra S. Kaphalia, Santosh Kumar, Mary F. Kanz & Mary Treinen-Moslen. (2006) Efficient high performance liquid chromatograph/ultraviolet method for determination of diclofenac and 4′-hydroxydiclofenac in rat serum. Journal of Chromatography B 830:2, pages 231-237.
Crossref
Crossref
Naomi Morita, Hiroyuki Kusuhara, Yoshitane Nozaki, Hitoshi Endou & Yuichi Sugiyama. (2005)
FUNCTIONAL INVOLVEMENT OF RAT ORGANIC ANION TRANSPORTER 2 (
SLC22A7
) IN THE HEPATIC UPTAKE OF THE NONSTEROIDAL ANTI-INFLAMMATORY DRUG KETOPROFEN
. Drug Metabolism and Disposition 33:8, pages 1151-1157.
Crossref
Crossref
Zhengyin Yan, Jian Li, Norman Huebert, Gary W. Caldwell, Yanming Du & Hua Zhong. (2005) DETECTION OF A NOVEL REACTIVE METABOLITE OF DICLOFENAC: EVIDENCE FOR CYP2C9-MEDIATED BIOACTIVATION VIA ARENE OXIDES. Drug Metabolism and Disposition 33:6, pages 706-713.
Crossref
Crossref
A.G. Wang, T. Xia, J. Yuan, R.A. Yu, K.D. Yang, X.M. Chen, W. Qu & M.P. Waalkes. (2004) Effects of phenobarbital on metabolism and toxicity of diclofenac sodium in rat hepatocytes in vitro. Food and Chemical Toxicology 42:10, pages 1647-1653.
Crossref
Crossref
Caroline D. Marel, Brian J. Anderson, Janne Romsing, Evelyne Jacqz-Aigrain & Dick Tibboel. (2004) Diclofenac and metabolite pharmacokinetics in children. Pediatric Anesthesia 14:6, pages 443-451.
Crossref
Crossref
I.A. Wasfi, M.M. Hussain, M. Elghazali, Nawal A. Alkatheeri & A.A. Abdel Hadi. (2003) The disposition of diclofenac in camels after intravenous administration. The Veterinary Journal 166:3, pages 277-283.
Crossref
Crossref
Maria Shipkova, Victor William Armstrong, Michael Oellerich & Eberhard Wieland. (2003) Acyl Glucuronide Drug Metabolites: Toxicological and Analytical Implications. Therapeutic Drug Monitoring 25:1, pages 1-16.
Crossref
Crossref
Julia Kirchheiner, Ingolf Meineke, Nadine Steinbach, Christian Meisel, Ivar Roots & Jürgen Brockmöller. (2003) Pharmacokinetics of diclofenac and inhibition of cyclooxygenases 1 and 2: no relationship to the CYP2C9 genetic polymorphism in humans. British Journal of Clinical Pharmacology 55:1, pages 51-61.
Crossref
Crossref
Sanjeev Kumar, Koppara Samuel, Ramaswamy Subramanian, Matthew P. Braun, Ralph A. Stearns, Shuet-Hing Lee Chiu, David C. Evans & Thomas A. Baillie. (2002) Extrapolation of Diclofenac Clearance from in Vitro Microsomal Metabolism Data: Role of Acyl Glucuronidation and Sequential Oxidative Metabolism of the Acyl Glucuronide. Journal of Pharmacology and Experimental Therapeutics 303:3, pages 969-978.
Crossref
Crossref
Priyanka Arora & Biswajit Mukherjee. (2002) Design, development, physicochemical, and in vitro and in vivo evaluation of transdermal patches containing diclofenac diethylammonium salt. Journal of Pharmaceutical Sciences 91:9, pages 2076-2089.
Crossref
Crossref
Catherine J. Duckett, Nigel J. C. Bailey, Heather Walker, Fadi Abou-Shakra, Ian D. Wilson, John C. Lindon & Jeremy K. Nicholson. (2002) Quantitation in gradient high performance liquid chromatography/inductively coupled mass spectrometry investigated using diclofenac and chlorpromazine. Rapid Communications in Mass Spectrometry 16:4, pages 245-247.
Crossref
Crossref
K Walton, J.L Dorne & A.G Renwick. (2001) Uncertainty factors for chemical risk assessment: interspecies differences in glucuronidation. Food and Chemical Toxicology 39:12, pages 1175-1190.
Crossref
Crossref
Guruprasad P. Aithal, Christopher P. Day, Julian B. S. Leathart & Ann K. Daly. (2000) Relationship of polymorphism in CYP2C9 to genetic susceptibility to diclofenac-induced hepatitis. Pharmacogenetics 10:6, pages 511-518.
Crossref
Crossref
H. Tanojo, R. C. Wester, J. Z. Shainhouse & H. I. Maibach. (1999) Diclofenac metabolic profile followingin vitro percutaneous absorption through viable human skin. European Journal of Drug Metabolism and Pharmacokinetics 24:4, pages 345-351.
Crossref
Crossref
G Giagoudakis & S.L Markantonis. (1998) An alternative high-performance liquid-chromatographic method for the determination of diclofenac and flurbiprofen in plasma. Journal of Pharmaceutical and Biomedical Analysis 17:4-5, pages 897-901.
Crossref
Crossref
Mohamed Osman, Appavu Chandrasekaran, Kelvin Chan, JoAnn Scatina, James Ermer, William Cevallos & Samuel F. Sisenwine. (2013)
Metabolic Disposition of
14
C‐Bromfenac in Healthy Male Volunteers
. The Journal of Clinical Pharmacology 38:8, pages 744-752.
Crossref
Crossref
Joseph A. Ware, Mary Louise M. Graf, Brian M. Martin, Lisa R. Lustberg & Lance R. Pohl. (1998) Immunochemical Detection and Identification of Protein Adducts of Diclofenac in the Small Intestine of Rats: Possible Role in Allergic Reactions. Chemical Research in Toxicology 11:3, pages 164-171.
Crossref
Crossref
Lara T. WadeJ. Gerald KennaJohn Caldwell. (1997) Immunochemical Identification of Mouse Hepatic Protein Adducts Derived from the Nonsteroidal Anti-Inflammatory Drugs Diclofenac, Sulindac, and Ibuprofen. Chemical Research in Toxicology 10:5, pages 546-555.
Crossref
Crossref
Toshio Hirai, Shozo Matsumoto & Ikuo Kishi. (1997) Simultaneous analysis of several non-steroidal anti-inflammatory drugs in human urine by high-performance liquid chromatography with normal solid-phase extraction. Journal of Chromatography B: Biomedical Sciences and Applications 692:2, pages 375-388.
Crossref
Crossref
Motoo Uejima, Takemi Kinouchi, Keiko Kataoka, Isao Hiraoka & Yoshinari Ohnishi. (2013) Role of Intestinal Bacteria in Ileal Ulcer Formation in Rats Treated with a Nonsteroidal Antiinflammatory Drug. Microbiology and Immunology 40:8, pages 553-560.
Crossref
Crossref
A. Avgerinos, Th. Karidas & S. Malamataris. (1993) Extractionless high-performance liquid chromatographic method for the determination of diclofenac in human plasma and urine. Journal of Chromatography B: Biomedical Sciences and Applications 619:2, pages 324-329.
Crossref
Crossref
T. Leemann, C. Transon & P. Dayer. (1993) Cytochrome P450TB (CYP2C): A major monooxygenase catalyzing diclofenac 4′-hydroxylation in human liver. Life Sciences 52:1, pages 29-34.
Crossref
Crossref
Mark E. Adams, Ding Qiu Huang, Lena Yue Yao & Linda J. Sandell. (1992) Extraction and isolation of mRNA from adult articular cartilage. Analytical Biochemistry 202:1, pages 89-95.
Crossref
Crossref
J. Suryakumar, T. Chakrapani & D. R. Krishna. (2012) Famotidine Affects the Pharmacokinetics of Diclofenac Sodium. Drug Investigation 4:1, pages 66-68.
Crossref
Crossref
Federico M. Rubino & Luigi Zecca. (1992) Molecular characterization of diclofenac and its hydroxylated metabolites by tandem mass spectrometry. Biological Mass Spectrometry 21:2, pages 109-113.
Crossref
Crossref
I. Wiesenberg-Boettcher, J. Pfeilschifter, A. Schweizer, A. Sallmann & P. Wenk. (1991) Pharmacological properties of five diclofenac metabolites identified in human plasma. Agents and Actions 34:1-2, pages 135-137.
Crossref
Crossref
K.W.M. Zuurbier, A.R.J. Bakkenist, R.H. Fokkens, N.M.M. Nibbering, R. Wever & A.O. Muijsers. (1990) Interaction of myeloperoxidase with diclofenac. Biochemical Pharmacology 40:8, pages 1801-1808.
Crossref
Crossref
D. Lansdorp, T.J. Janssen, P.J.M. Guelen & T.B. Vree. (1990) High-performance liquid chromatographic method for the determination of diclofenac and its hydroxy metabolites in human plasma and urine. Journal of Chromatography B: Biomedical Sciences and Applications 528, pages 487-494.
Crossref
Crossref
D. Grandjean, J.C. Beolor, M.T. Quincon & E. Savel. (1989) Automated Robotic Extraction and Subsequent Analysis of Diclofenac in Plasma Samples. Journal of Pharmaceutical Sciences 78:3, pages 247-249.
Crossref
Crossref
G.L. LARSEN. 1988. Role of the Gut Flora in Toxicity and Cancer. Role of the Gut Flora in Toxicity and Cancer
79
107
.
Shun-Ichi Naito & Hideharu Tominaga. (1985) Percutaneous absorption of diclofenac sodium ointment. International Journal of Pharmaceutics 24:1, pages 115-124.
Crossref
Crossref
J. Godbillon, S. Gauron & J.P. Metayer. (1985) High-performance liquid chromatographic determination of diclofenac and its monohydroxylated metabolites in biological fluids. Journal of Chromatography B: Biomedical Sciences and Applications 338, pages 151-159.
Crossref
Crossref
Y. Ruckebusch & P. L. Toutain. (1983) Nonsteroidal anti-inflammatory agents: Species differences in pharmacodynamics. Veterinary Research Communications 7:1, pages 359-368.
Crossref
Crossref
W. Schneider & P.H. Degen. (1981) Simultaneous determination of diclofenac sodium and its hydroxy metabolites by capillary column gas chromatography with electron-capture detection. Journal of Chromatography A 217, pages 263-271.
Crossref
Crossref
Jerome Edelson, David P. Benziger & James E. Peterson. 1981. Annual Reports in Medicinal Chemistry Volume 16. Annual Reports in Medicinal Chemistry Volume 16
319
327
.
J. V. Willis, D. B. Jack, M. J. Kendall & V. A. John. (1981) The influence of food on the absorption of diclofenac as determined by the urinary excretion of the unchanged drug and its major metabolites during chronic administration. European Journal of Clinical Pharmacology 19:1, pages 39-44.
Crossref
Crossref
A.A.J. Goldberg & K.E. Godfrey. (1980) Fenclofenac. Clinics in Rheumatic Diseases 6:3, pages 647-674.
Crossref
Crossref
A. Schweizer, J.V. Willis, D.B. Jack & M.J. Kendall. (1980) Determination of total monohydroxylated metabolites of diclofenac in urine by electron-capture gas-liquid chromatography. Journal of Chromatography A 195:3, pages 421-424.
Crossref
Crossref