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Xenobiotica
the fate of foreign compounds in biological systems
Volume 9, 1979 - Issue 12
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Research Article

The Detoxication of Aflatoxin B1 with Glutathione in the Rat

G. O. Emerole Biochemistry Department, University of Ibadan, Ibadan, Nigeria
,
N. Neskovic INEP, Department of Pesticides, Baraniska, No. 15, P.O. Box 46, 11080, Zemun, Yugoslavia
&
R. L. Dixon National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, 27709, USA
Pages 737-743 | Received 02 Feb 1979, Published online: 22 Sep 2008

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Brian Coles, Brian Ketterer & Jack A. Hinson. (1990) The Role of Glutathione and Glutathione Transferases in Chemical Cardnogenesi. Critical Reviews in Biochemistry and Molecular Biology 25:1, pages 47-70.
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HowardS. Ramsdell & DavidL. Eaton. (1988) Modification of aflatoxin B1 biotransformation in vitro and DNA binding in vivo by dietary broccoli in rats. Journal of Toxicology and Environmental Health 25:3, pages 269-284.
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C. J. Holeski, D. L. Eaton, D. H. Monroe & G. M. Bellamy. (1987) Effects of phenobarbital on the biliary excretion of aflatoxin P 1-glucuronide and aflatoxin B1-S-glutathione in the rat. Xenobiotica 17:2, pages 139-153.
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Sue Baldwin & RobertS. Parker. (1986) The effects of dietary fat and selenium on the development of preneoplastic lesions in rat liver. Nutrition and Cancer 8:4, pages 273-282.
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Brian Coles. (1984) Effects of Modifying Structure on Electrophilic Reactions with Biological Nucleophiles. Drug Metabolism Reviews 15:7, pages 1307-1334.
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Brian Ketterer. (1982) The Role of Nonenzymatic Reactions of Glutathione in Xenobiotic Metabolism. Drug Metabolism Reviews 13:1, pages 161-187.
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Articles from other publishers (31)

D.L. Eaton, K.M. Beima, T.K. Bammler, R.T. Riley & K.A. Voss. 2018. Comprehensive Toxicology. Comprehensive Toxicology 483 521 .
Scott S. Auerbach, Dhiral P. Phadke, Deepak Mav, Stephanie Holmgren, Yuan Gao, Bin Xie, Joo Heon Shin, Ruchir R. Shah, B. Alex Merrick & Raymond R. Tice. (2015) RNA-Seq-based toxicogenomic assessment of fresh frozen and formalin-fixed tissues yields similar mechanistic insights. Journal of Applied Toxicology 35:7, pages 766-780.
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D.L. Eaton, K.M. Beima, T.K. Bammler, R.T. Riley & K.A. Voss. 2010. Comprehensive Toxicology. Comprehensive Toxicology 527 569 .
Hasan Özen, Musa Karaman, Yılmaz Çiğremiş, Mehmet Tuzcu, Kadir Özcan & Dinçer Erdağ. (2009) Effectiveness of melatonin on aflatoxicosis in chicks. Research in Veterinary Science 86:3, pages 485-489.
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D. Tedesco, S. Steidler, S. Galletti, M. Tameni, O. Sonzogni & L. Ravarotto. (2004) Efficacy of silymarin-phospholipid complex in reducing the toxicity of aflatoxin B1 in broiler chicks. Poultry Science 83:11, pages 1839-1843.
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T Quezada, H Cuéllar, F Jaramillo-Juárez, A.G Valdivia & J.L Reyes. (2000) Effects of aflatoxin B1 on the liver and kidney of broiler chickens during development. Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology 125:3, pages 265-272.
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Tae Gil Ha, Woong Chon Mar, Sang Geon Kim, Young-Joon Surh & Nak Doo Kim. (1999) Enhancement of biliary excretion of aflatoxin B1 and suppression of hepatic ornithine decarboxylase activity by 2-(allylthio)pyrazine in rats. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 428:1-2, pages 59-67.
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David L. Eaton. 1999. Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes. Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes 195 209 .
Shao-Win Wang, Chung-Yih Lai & Chau-Jong Wang. (1992) Inhibitory effect of geniposide on aflatoxin B1-induced DNA repair synthesis in primary cultured rat hepatocytes. Cancer Letters 65:2, pages 133-137.
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K.W. Beers, R.P. Glahn, W.G. Bottje & W.E. Huff. (1992) Aflatoxin and glutathione in domestic fowl (Gallus domesticus)—II. Effects on hepatic blood flow. Comparative Biochemistry and Physiology Part C: Comparative Pharmacology 101:3, pages 463-467.
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K.W. Beers, H. Nejad & W.G. Bottje. (1992) Aflatoxin and glutathione in domestic fowl (Gallus domesticus)—I. Glutathione elevation and attenuation by high dietary methionine. Comparative Biochemistry and Physiology Part C: Comparative Pharmacology 101:2, pages 239-244.
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C.-J. Wang, S.-W. Wang & J.-K. Lin. (1991) Suppressive effect of geniposide on the hepatotoxicity and hepatic DNA binding of aflatoxin B1 in rats. Cancer Letters 60:2, pages 95-102.
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John J. Ch'ih, Diane W. Biedrzycka & Thomas M. Devlin. (1991) Isolated hepatocytes are capable of excreting aflatoxin metabolites. Biochemical and Biophysical Research Communications 178:3, pages 1002-1007.
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Robert F. Frick & Juan Jorge. (2006) Methylthiazolidine‐4‐carboxylate for treatment of acute T‐2 toxin exposure. Journal of Applied Toxicology 11:2, pages 135-140.
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C.-J. Wang, H.-S. Shiah & J.-K. Lin. (1991) Modulatory effect of crocetin on aflatoxin B1 cytotoxicity and DNA adduct formation in C3H10T12 fibroblast cell. Cancer Letters 56:1, pages 1-10.
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David L. Eaton, Howard Ramsdell & David H. Monroe. 1990. Microbial Toxins in Foods and Feeds. Microbial Toxins in Foods and Feeds 275 290 .
David H. Monroe & David L. Eaton. (1988) Effects of modulation of hepatic glutathione on biotransformation and covalent binding of aflatoxin B1 to DNA in the mouse. Toxicology and Applied Pharmacology 94:1, pages 118-127.
Crossref
David H. Monroe & David L. Eaton. (1987) Comparative effects of butylated hydroxyanisole on hepatic in vivo DNA binding and in vitro biotransformation of aflatoxin B1 in the rat and mouse. Toxicology and Applied Pharmacology 90:3, pages 401-409.
Crossref
D.H. Monroe, C.J. Holeski & D.L. Eaton. (1986) Effects of single-dose and repeated-dose pretreatment with 2(3)-tert-butyl-4-hydroxyanisole (BHA) on the hepatobiliary disposition and covalent binding to DNA of aflatoxin B1 in the rat. Food and Chemical Toxicology 24:12, pages 1273-1281.
Crossref
S. Hendrich & L.F. Bjeldanes. (1986) Effects of Dietary Schizandra chinensis, Brussels sprouts and Illicium verum extracts on carcinogen metabolism systems in mouse liver. Food and Chemical Toxicology 24:9, pages 902-912.
Crossref
Gunter Wagner, Hartmut Frenzel, Heribert Wefers & Helmut Sies. (1985) Lack of effect of long-term glutathione administration on aflatoxin B1-induced hepatoma in male rats. Chemico-Biological Interactions 53, pages 57-68.
Crossref
Richard E. Morrissey, William P. Norred, Richard J. Cole & Joe Dorner. (1985) Toxicity of the mycotoxin, cyclopiazonic acid, to Sprague-Dawley rats. Toxicology and Applied Pharmacology 77:1, pages 94-107.
Crossref
Godwin O. Emerole, M. Ira Thabrew & Helen O. Kwanashie. (1984) Effect of dietary vitamin E (α-tocopherol) on aflatoxin B metabolism. European Journal of Drug Metabolism and Pharmacokinetics 9:4, pages 295-300.
Crossref
Mendel Friedman. 1984. Nutritional and Toxicological Aspects of Food Safety. Nutritional and Toxicological Aspects of Food Safety 31 63 .
C. Lowery, T.C. Orton & R.C. Garner. (1983) Metabolic activation and bacterial mutagenicity of aflatoxin B1 in two different test systems. Toxicology 29:1-2, pages 131-141.
Crossref
G.E. Neal & J.A. Green. (1983) The requirement for glutathione S-transferase in the conjugation of activated aflatoxin B1 during aflatoxin hepatocarcinogenesis in the rat. Chemico-Biological Interactions 45:2, pages 259-275.
Crossref
Brian Ketterer, Brian Coles & David J. Meyer. (1983) The role of glutathione in detoxication. Environmental Health Perspectives 49, pages 59-69.
Crossref
John J. Ch'ih, Tzu Lin & Thomas M. Devlin. (1983) Activation and deactivation of aflatoxin B1 in isolated rat hepatocytes. Biochemical and Biophysical Research Communications 110:2, pages 668-674.
Crossref
J.H.N. Meerman, F.A. Beland, B. Ketterer, S.K.S. Srai, A.P. Bruins & G.J. Mulder. (1982) Identification of glutathione conjugates formed from N-hydroxy-2-acetylaminofluorene in the rat. Chemico-Biological Interactions 39:2, pages 149-168.
Crossref
J. H. Weisburger & G. M. Williams. 1982. Etiology: Chemical and Physical Carcinogenesis. Etiology: Chemical and Physical Carcinogenesis 241 333 .
Godwin O. Emerole. (1981) Excretion of Aflatoxin B1 as a glutathione conjugate. European Journal of Drug Metabolism and Pharmacokinetics 6:4, pages 265-268.
Crossref

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