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Xenobiotica
the fate of foreign compounds in biological systems
Volume 9, 1979 - Issue 8
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Original Article

The oxidation of azaheterocycles with mammalian liver aldehyde oxidase

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Pages 475-484 | Received 22 Jan 1979, Published online: 30 Sep 2009

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John B. Sutherland, James P. Freeman, Anna J. Williams & Joanna Deck. (1999) Biotransformation of phthalazine by Fusarium moniliforme and Cunninghamella elegans. Mycologia 91:1, pages 114-116.
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R. M. Wright, L. K. Weigel, M. Varella-Garcia, G. Vaitaitis & J. E. Repine. (1997) Molecular cloning, refined chromosomal mapping and structural analysis of the human gene encoding aldehyde oxidase (AOX1), a candidate for the ALS2 gene. Redox Report 3:3, pages 135-144.
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A. A. Acheampong, D-S. Chien, S. Lam, S. Vekich, A. Breau, J. Usansky, D. Harcourt, S. A. Munk, H. Nguyen, M. Garst & D. Tang-Liu. (1996) Characterization of brimonidine metabolism with rat, rabbit, dog, monkey and human liver fractions and rabbit liver aldehyde oxidase. Xenobiotica 26:10, pages 1035-1055.
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C. Johnson, C. Beedham & J. G. P. Stell. (1987) Reaction of 1-amino- and 1-chlorophthalazine with mammalian molybdenum hydroxylases in vitro. Xenobiotica 17:1, pages 17-24.
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B. Kaye, D. J. Rance & L. Waring. (1985) Oxidative metabolism of carbazeran in vitro by liver cytosol of baboon and man. Xenobiotica 15:3, pages 237-242.
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B. Kaye, J. L. Offerman, J. L. Reid, H. L. Elliott & W. S. Hillis. (1984) A species difference in the presystemic metabolism of carbazeran in dog and man. Xenobiotica 14:12, pages 935-945.
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B. Furnival, J. M. Harrison, J. Newman & D. G. Upshall. (1983) The fate of dibenz[b,f]-1,4-oxazepine (CR) in the rat. Part II. Metabolism in vitro. Xenobiotica 13:6, pages 361-372.
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L. A. Damani, P. A. Crooks, M. S. Shaker, J. Caldwell, J. D'souza & R. L. Smith. (1982) Species differences in the metabolic C- and N-oxidation, and N-methylation of [14C]pyridine in vivo. Xenobiotica 12:8, pages 527-534.
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Articles from other publishers (34)

Mengting Huang, Keyun Zhu, Yimeng Wang, Chaofeng Lou, Huimin Sun, Weihua Li, Yun Tang & Guixia Liu. (2023) In Silico Prediction of Metabolic Reaction Catalyzed by Human Aldehyde Oxidase. Metabolites 13:3, pages 449.
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Mineko Terao, Enrico Garattini, Maria João Romão & Silke Leimkühler. (2020) Evolution, expression, and substrate specificities of aldehyde oxidase enzymes in eukaryotes. Journal of Biological Chemistry 295:16, pages 5377-5389.
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Nenad Manevski, Lloyd King, William R. Pitt, Fabien Lecomte & Francesca Toselli. (2019) Metabolism by Aldehyde Oxidase: Drug Design and Complementary Approaches to Challenges in Drug Discovery. Journal of Medicinal Chemistry 62:24, pages 10955-10994.
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Mineko Terao, Maria João Romão, Silke Leimkühler, Marco Bolis, Maddalena Fratelli, Catarina Coelho, Teresa Santos-Silva & Enrico Garattini. (2016) Structure and function of mammalian aldehyde oxidases. Archives of Toxicology 90:4, pages 753-780.
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Nenad Manevski, Kamal Kumar Balavenkatraman, Barbara Bertschi, Piet Swart, Markus Walles, Gian Camenisch, Hilmar Schiller, Olivier Kretz, Barbara Ling, Reto Wettstein, Dirk J. Schaefer, Francois Pognan, Armin Wolf & Karine Litherland. (2014) Aldehyde Oxidase Activity in Fresh Human Skin. Drug Metabolism and Disposition 42:12, pages 2049-2057.
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Alexander V. LyubimovMichael Zientek, Ping Kang, Matthew J. Hutzler & Scott R. Obach. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 59 .
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Tapan K. Kundu, Murugesan Velayutham & Jay L. Zweier. (2012) Aldehyde Oxidase Functions as a Superoxide Generating NADH Oxidase: An Important Redox Regulated Pathway of Cellular Oxygen Radical Formation. Biochemistry 51:13, pages 2930-2939.
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Raman Sharma, Heather Eng, Gregory S. Walker, Gabriela Barreiro, Antonia F. Stepan, Kim F. McClure, Angela Wolford, Paul D. Bonin, Peter Cornelius & Amit S. Kalgutkar. (2011) Oxidative Metabolism of a Quinoxaline Derivative by Xanthine Oxidase in Rodent Plasma. Chemical Research in Toxicology 24:12, pages 2207-2216.
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. (2011) Scientific Opinion on Flavouring Group Evaluation 17, Revision 3 (FGE.17Rev3): Pyrazine derivatives from chemical group 24. EFSA Journal 9:11.
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. (2011) Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24. EFSA Journal 9:5.
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C Beedham. (1986) Similarity in the aldehyde oxidases from guinea-pig liver and polymorphonuclear leucocytes. Journal of Pharmacy and Pharmacology 38:1, pages 57-58.
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C Johnson, J G P Stell & C Stubley. (1982) The Inhibition of Rabbit Liver Aldehyde Oxidase by Hydralazine. Journal of Pharmacy and Pharmacology 34:Supplement_12, pages 63P-63P.
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C Stubley & J G P Stell. (1980) Investigation of the Substrate-Binding Site of Aldehyde Oxidase. Journal of Pharmacy and Pharmacology 32:Supplement_1, pages 51P-51P.
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John B. Sutherland, Thomas M. Heinze, Laura K. Schnackenberg, James P. Freeman & Anna J. Williams. (2011) Biotransformation of quinazoline and phthalazine by Aspergillus niger. Journal of Bioscience and Bioengineering 111:3, pages 333-335.
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. (2008) Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC). EFSA Journal 6:9, pages 812.
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Tapan Kumar Kundu, Russ Hille, Murugesan Velayutham & Jay L. Zweier. (2007) Characterization of superoxide production from aldehyde oxidase: An important source of oxidants in biological tissues. Archives of Biochemistry and Biophysics 460:1, pages 113-121.
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Sugima Rappert, Kathrin Caroline Botsch, Stephanie Nagorny, Wittko Francke & Rudolf Müller. (2006) Degradation of 2,3-Diethyl-5-Methylpyrazine by a Newly Discovered Bacterium, Mycobacterium sp. Strain DM-11 . Applied and Environmental Microbiology 72:2, pages 1437-1444.
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. (2006) Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Comm. EFSA Journal 4:1, pages 295.
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Eugene Olajos. 2004. Riot Control Agents. Riot Control Agents 37 64 .
Dieter Lang & Amit Kalgutkar. 2003. Drug Metabolizing Enzymes. Drug Metabolizing Enzymes 483 539 .
T.B Adams, J Doull, V.J Feron, J.I Goodman, L.J Marnett, I.C Munro, P.M Newberne, P.S Portoghese, R.L Smith, W.J Waddell & B.M Wagner. (2002) The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients. Food and Chemical Toxicology 40:4, pages 429-451.
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M. Lehmann, B. Tshisuaka, S. Fetzner, P. Röger & F. Lingens. (1994) Purification and characterization of isoquinoline 1-oxidoreductase from Pseudomonas diminuta 7, a novel molybdenum-containing hydroxylase. Journal of Biological Chemistry 269:15, pages 11254-11260.
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Martina Blaschke, Annette Kretzer, Christine Schäfer, Matthias Nagel & Jan R. Andreesen. (1991) Molybdenum-dependent degradation of quinoline by Pseudomonas putida Chin IK and other aerobic bacteria. Archives of Microbiology 155:2, pages 164-169.
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Christine Beedham, Sally E. Bruce, David J. Critchley & David J. Rance. (1990) 1-Substituted phthalazines as probes of the substrate-binding site of mammalian molybdenum hydroxylases. Biochemical Pharmacology 39:7, pages 1213-1221.
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Christine Beedham. 1987. 85 127 .
Christine Johnson, Christine Stubley-Beedham, J. Godfrey & P. Stell. (1985) Hydralazine: A potent inhibitor of aldehyde oxidase activity in vitro and in vivo. Biochemical Pharmacology 34:24, pages 4251-4256.
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Peter C. Ruenitz & H.Greg Thomas. (1985) Primary deuterium isotope effect in the oxidation of an iminium ion by aldehyde oxidase. Archives of Biochemistry and Biophysics 239:1, pages 270-272.
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Christine Johnson, Christine Stubley-Beedham & J.Godfrey P. Stell. (1984) Elevation of molybdenum hydroxylase levels in rabbit liver after ingestion of phthalazine or its hydroxylated metabolite. Biochemical Pharmacology 33:22, pages 3699-3705.
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H. Greg Thomas & Peter C. Ruenitz. (2009) Mechanistic aspects of oxidation of N ‐substituted 5 H ‐dibenz[ c,e ]azepines by aldehyde oxidase . Journal of Heterocyclic Chemistry 21:4, pages 1057-1062.
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. 1984. Comprehensive Heterocyclic Chemistry. Comprehensive Heterocyclic Chemistry 673 731 .
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V Facchini & JA Timbrell. (2012) Further evidence for an acetylator phenotype difference in the metabolism of hydralazine in man.. British Journal of Clinical Pharmacology 11:4, pages 345-351.
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