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Xenobiotica
the fate of foreign compounds in biological systems
Volume 10, 1980 - Issue 1
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Research Article

The stereoselective enzymic reduction of the synthetic 9-ketocannabinoid, nabilone, in vivo, in isolated liver cells and in liver homogenate

R. E. Billings Lilly Research Laboratories, Indianopolis, IN, 46206, USA
,
G. W. Whitaker Lilly Research Laboratories, Indianopolis, IN, 46206, USA
&
R. E. McMahon Lilly Research Laboratories, Indianopolis, IN, 46206, USA
Pages 33-36 | Received 15 Apr 1979, Published online: 22 Sep 2008

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T. Kimura, M. Miki, K. Watanabe, S. Kondo, I. K. Ho & I. Yamamoto. (2000) Metabolism of a novel hypnotic, N3-phenacyluridine, and hypnotic and sedative activities of its enantiomer metabolites in mouse. Xenobiotica 30:6, pages 643-653.
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T. NAITOH, S. KAWAGUCHI, M. KAKIKI, H. OHE, A. KAJIWARA & T. HORIE. (1998) Species differences and mechanism of the epimerization of a new MAO-A inhibitor. Xenobiotica 28:3, pages 269-280.
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J. Jodynis-Liebert. (1993) Metabolism of 1-(4-hydroxy-3-methoxyphenyl)-2-propanone, a smoke flavour ketone, in rat. Xenobiotica 23:6, pages 693-701.
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H. R. Sullivan, G. K. Hanasono, W. M. Miller & P. G. Wood. (1987) Species specificity in the metabolism of nabilone. Relationship between toxicity and metabolic routes. Xenobiotica 17:4, pages 459-468.
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Articles from other publishers (5)

Mauro Maccarrone, Vincenzo Di Marzo, Jürg Gertsch, Uwe Grether, Allyn C. Howlett, Tian Hua, Alexandros Makriyannis, Daniele Piomelli, Natsuo Ueda & Mario van der Stelt. (2023) Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years. Pharmacological Reviews 75:5, pages 885-958.
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D. J. Harvey & N. K. Brown. (1990) Metabolites of the 1′,2′-dimethylheptyl analogue of delta-8-tetrahydrocannabinol in the mouse and their identification by gas chromatography/mass spectrometry. Biological Mass Spectrometry 19:10, pages 619-627.
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Hideo Naganuma, Jun-ichi Kondo & Yukinori Kawahara. (1990) Enantiospecific assay for mammalian carbonyl reductase by liquid chromatography with fluorescence detection. Journal of Chromatography B: Biomedical Sciences and Applications 532, pages 65-74.
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Louis Lemberger, Alan Rubin, Robert Wolen, Karl DeSante, Howard Rowe, Robert Forney & Peggy Pence. (1982) Pharmacokinetics, metabolism and drug-abuse potential of nabilone. Cancer Treatment Reviews 9, pages 17-23.
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ROBERT E. MCMAHON. 1982. Metabolic Basis of Detoxication. Metabolic Basis of Detoxication 91 104 .

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