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Xenobiotica
the fate of foreign compounds in biological systems
Volume 10, 1980 - Issue 2
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Research Article

The metabolism of 3-chloro-4-fluoro-aniline in dog and rat

M. K. Baldwin Shell Research Limited, Shell Toxicology Laboratory (Tunstall), Sittingbourne Research Centre, Sittingbourne, Kent, ME9 8AG, UK
&
D. H. Hutson Shell Research Limited, Shell Toxicology Laboratory (Tunstall), Sittingbourne Research Centre, Sittingbourne, Kent, ME9 8AG, UK
Pages 135-144 | Received 21 Jun 1979, Published online: 22 Sep 2008

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C. J. Duckett, J. C. Lindon, H. Walker, F. Abou-Shakra, I. D. Wilson & J. K. Nicholson. (2006) Metabolism of 3-chloro-4-fluoroaniline in rat using [14C]-radiolabelling, 19F-NMR spectroscopy, HPLC-MS/MS, HPLC-ICPMS and HPLC-NMR. Xenobiotica 36:1, pages 59-77.
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G. B. Scarfe, I. D. Wilson, M. A. Warne, E. Holmes, J. K. Nicholson & J. C. Lindon. (2002) Structure-metabolism relationships of substituted anilines: prediction of N-acetylation and N-oxanilic acid formation using computational chemistry. Xenobiotica 32:4, pages 267-277.
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G. B. SCARFE. (1999) Studies on the metabolism of 4-fluoroaniline and 4-fluoroacetanilide in rat: formation of 4-acetamidophenol (paracetamol) and its metabolites via defluorination and N-acetylation. Xenobiotica 29:2, pages 205-216.
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S. K. HONG. (1998) Biotransformation of 2-chloroaniline in the Fischer 344 rat: identification of urinary metabolites. Xenobiotica 28:10, pages 985-994.
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T. Yoshimura, S. Tanaka, H. Sakurai, Y. Nagai, K. Yamada, S. Katayama, S. Abe & I. Yamatsu. (1991) Metabolism and excretion of a new 5-lipoxygenase inhibitor in rats, guinea-pigs, beagles and rhesus monkeys. Xenobiotica 21:5, pages 627-634.
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J. Vervoort, P. A. De Jager, J. Steenbergen & I. M. C. M. Rietjens. (1990) Development of a 19F-n.m.r. method for studies on the in vivo and in vitro metabolism of 2-fluoroaniline. Xenobiotica 20:7, pages 657-670.
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Ivonne M. C. M. Rietjens & Jacques Vervoort. (1989) Microsomal metabolism of fluoroanilines. Xenobiotica 19:11, pages 1297-1305.
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C. V. Eadsforth, P. C. Coveney, D. H. Hutson, C. J. Logan & A. J. Samuel. (1986) The metabolism of o-fluoroaniline by rats, rabbits and marmosets. Xenobiotica 16:6, pages 555-566.
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C. J. Logan, D. H. Hutson & D. Hesk. (1985) The fate of 4-cyano-N, N-dimethylaniline in mice: The occurrence of a novel metabolite during N-demethylation of an aromatic amine. Xenobiotica 15:5, pages 391-397.
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D. H. Hutson, S. K. Lakeman & C. J. Logan. (1984) The fate of 4-cyano-N, N-dimethylaniline in rats; a novel involvement of glutathione in the metabolism of anilines. Xenobiotica 14:12, pages 925-934.
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G. D. Paulson, G. L. Lamoureux & V. J. Feil. (1982) Advances in methods and techniques for the identification of Xeno-biotic conjugates. Journal of Toxicology: Clinical Toxicology 19:6-7, pages 571-608.
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Articles from other publishers (10)

Gabriele Sabbioni. (2017) Hemoglobin Adducts and Urinary Metabolites of Arylamines and Nitroarenes. Chemical Research in Toxicology 30:10, pages 1733-1766.
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I.M.C.M. Rietjens & J. Vervoort. (1991) Bioactivation of 4-fluorinated anilines to benzoquinoneimines as primary reaction products. Chemico-Biological Interactions 77:3, pages 263-281.
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I. M. C. M. Rietjens, J. Koerts, S. Boeren & J. Vervoort. (2010) Biosynthesis and chemical determination of polyfluoro-4-hydroxyanilines. Recueil des Travaux Chimiques des Pays-Bas 110:5, pages 216-221.
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. 1989. Metabolic Maps of Pesticides. Metabolic Maps of Pesticides 244 255 .
D. Hesk, D. H. Hutson, S. K. Lakeman & C. J. Logan. 1985. Comparative Genetic Toxicology. Comparative Genetic Toxicology 547 562 .
C. V. Eadsforth, C. J. Logan, B. J. Morrison & P. A. Warburton. (1984) 2,4-Difluoroaniline and 4-fluoroaniline exposure: monitoring by methaemoglobin and urine analyses. International Archives of Occupational and Environmental Health 54:3, pages 223-232.
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S.J. Barbee, E.I. Goldenthal, D.E. Rajasekaran & E.J.F. Spicer. (1984) Subchronic oral toxicology of 4-Fluoro-3-nitroaniline in the rat. Toxicology and Applied Pharmacology 72:3, pages 400-405.
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Jelka Tomašić. 1983. Drug Metabolite Isolation and Determination. Drug Metabolite Isolation and Determination 149 160 .
C. V. Eadsforth. 1983. Drug Metabolite Isolation and Determination. Drug Metabolite Isolation and Determination 119 133 .
Michael D. Corbett & Bernadette R. Corbett. (1981) Metabolism of 4-Chloronitrobenzene by the Yeast Rhodosporidium sp . Applied and Environmental Microbiology 41:4, pages 942-949.
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