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Xenobiotica
the fate of foreign compounds in biological systems
Volume 10, 1980 - Issue 2
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Research Article

Species variations in the N-methylation and quaternization of [14C]pyridine

J. D'souza Department of Biochemical and Experimental Pharmacology, St Mary's Hospital Medical School, Paddington, London, W2 1PG, UK
,
J. Caldwell Department of Biochemical and Experimental Pharmacology, St Mary's Hospital Medical School, Paddington, London, W2 1PG, UK
&
R. L. Smith Department of Biochemical and Experimental Pharmacology, St Mary's Hospital Medical School, Paddington, London, W2 1PG, UK
Pages 151-157 | Received 24 Aug 1979, Published online: 22 Sep 2008

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T. J. Wilke, W. R. Jondorf & G. Powis. (1989) Oxidative metabolism of 14C-pyridine by human and rat tissue subcellular fractions. Xenobiotica 19:9, pages 1013-1022.
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P. Eyer & W. Hell. (1983) The metabolism of 3-benzoylpyridine. Xenobiotica 13:11, pages 649-659.
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L. A. Damani, P. A. Crooks, M. S. Shaker, J. Caldwell, J. D'souza & R. L. Smith. (1982) Species differences in the metabolic C- and N-oxidation, and N-methylation of [14C]pyridine in vivo. Xenobiotica 12:8, pages 527-534.
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Articles from other publishers (41)

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Harpreet Kaur, Harmanjeet Harmanjeet, Troy Wanandy, Ronald L. Castelino, Kamal Sud, Matthew D. Jose, Gregory M. Peterson & Rahul P. Patel. (2019) High Pyridine Generation in Ceftazidime-Icodextrin Admixtures Used to Treat Peritoneal Dialysis-associated Peritonitis. Clinical Therapeutics 41:11, pages 2446-2451.
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Chunyang Chen, Doreen Bönisch, Robert Penzis, Thomas Winckler & Gerhard K. E. Scriba. (2018) Capillary Electrophoresis-Based Enzyme Assay for Nicotinamide N-Methyltransferase. Chromatographia 81:10, pages 1439-1444.
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David B Ramsden, Rosemary H Waring, David J Barlow & Richard B Parsons. (2017) Nicotinamide N -Methyltransferase in Health and Cancer . International Journal of Tryptophan Research 10, pages 117864691769173.
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Anne-Christine Macherey & Patrick M. Dansette. 2015. The Practice of Medicinal Chemistry. The Practice of Medicinal Chemistry 585 614 .
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Gerald L. KennedyJr.Jr.. 2003. Patty's Toxicology. Patty's Toxicology 1 158 .
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 19 .
. 2002. The MAK-Collection for Occupational Health and Safety. The MAK-Collection for Occupational Health and Safety 1 318 .
. (2011) Scientific Opinion on Flavouring Group Evaluation 17, Revision 3 (FGE.17Rev3): Pyrazine derivatives from chemical group 24. EFSA Journal 9:11.
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Roman Lang, Anika Wahl, Timo Stark & Thomas Hofmann. (2011) Urinary N -methylpyridinium and trigonelline as candidate dietary biomarkers of coffee consumption . Molecular Nutrition & Food Research 55:11, pages 1613-1623.
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. (2011) Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24. EFSA Journal 9:5.
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MS Shaker, PA Crooks & LA Damani. (1981) Metabolic C - and N -Oxidation and N -Methylation of [2,614C] Pyridine in Vivo: Determination of Urinary Metabolites by H.P.L.C. . Journal of Pharmacy and Pharmacology 33:Supplement_1, pages 10P-10P.
Crossref
Bernard Testa & Stefanie D. Krämer. (2008) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 5:11, pages 2171-2336.
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. (2008) Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC). EFSA Journal 6:9, pages 812.
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Karen L. Ericson, Vincent M. Maloney, J. Dennis Mahuren, Stephen P. Coburn & Thorsten P. Degenhardt. (2008) N-Methylpyridoxamine: Novel canine vitamin B6 urine metabolite. Bioorganic & Medicinal Chemistry Letters 18:6, pages 1845-1848.
Crossref
Anne-Christine Macherey & Patrick M. Dansette. 2008. The Practice of Medicinal Chemistry. The Practice of Medicinal Chemistry 674 696 .
. (2006) Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Comm. EFSA Journal 4:1, pages 295.
Crossref
Anne-Christine Macherey & Patrick M. Dansette. 2003. The Practice of Medicinal Chemistry. The Practice of Medicinal Chemistry 545 560 .
Michael M Iba, Truyen Nguyen & Jacqueline Fung. (2002) CYP1A1 induction by pyridine and its metabolites in HepG2 cells. Archives of Biochemistry and Biophysics 404:2, pages 326-334.
Crossref
Richard H. Stadler, Natalia Varga, Christian Milo, Benoit Schilter, Francia Arce Vera & Dieter H. Welti. (2002) Alkylpyridiniums. 2. Isolation and Quantification in Roasted and Ground Coffees. Journal of Agricultural and Food Chemistry 50:5, pages 1200-1206.
Crossref
Henry J. Trochimowicz, Gerald L. KennedyJr.Jr. & Neil D. Krivanek. 2003. Patty's Toxicology. Patty's Toxicology.
Michael M. Iba, Jacqueline Fung, John V. Giannone & Allan B. Okey. (2000) Comparative Induction of CYP1A1 Expression by Pyridine and Its Metabolites. Archives of Biochemistry and Biophysics 378:2, pages 299-310.
Crossref
Richard M. WeinshilboumDiane M. OtternessCarol L. Szumlanski. (1999) METHYLATION PHARMACOGENETICS: Catechol O-Methyltransferase, Thiopurine Methyltransferase, and Histamine N-Methyltransferase. Annual Review of Pharmacology and Toxicology 39:1, pages 19-52.
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LAN YAN, DIANE M. OTTERNESS, CHRISTINE A. KOZAK & RICHARD M. WEINSHILBOUM. (1998) Mouse Nicotinamide N-Methyltransferase Gene: Molecular Cloning, Structural Characterization, and Chromosomal Localization. DNA and Cell Biology 17:8, pages 659-667.
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Atsushi Okamura, Yoshihisa Ohmura, Md. Muzharul Islam, Masatoshi Tagawa, Keisuke Horitsu, Yoichi Moriyama & Shinji Fujimura. (2005) Increased Hepatic Nicotinamide N‐Methyltransferase Activity as a Marker of Cancer Cachexia in Mice Bearing Colon 26 Adenocarcinoma. Japanese Journal of Cancer Research 89:6, pages 649-656.
Crossref
Lan Yan, Diane M Otterness, Timothy L Craddock & Richard M Weinshilboum. (1997) Mouse Liver Nicotinamide N-Methyltransferase:. Biochemical Pharmacology 54:10, pages 1139-1149.
Crossref
Gary P. Carlson. (1996) Comparison of the effects of pyridine and its metabolites on rat liver and kidney. Toxicology Letters 85:3, pages 173-178.
Crossref
S. Aksoy, C.L. Szumlanski & R.M. Weinshilboum. (1994) Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization.. Journal of Biological Chemistry 269:20, pages 14835-14840.
Crossref
Kazuo Matsubara, Edward J. Neafsey & Michael A. Collins. (2006) Novel S‐Adenosylmethionine‐Dependent Indole‐N‐Methylation of β‐Carbolines in Brain Particulate Fractions. Journal of Neurochemistry 59:2, pages 511-518.
Crossref
RALPH L. REED. 1990. Nitrogen and Phosphorus Solvents. Nitrogen and Phosphorus Solvents 259 267 .
Theodore A. Alston & Robert H. Abeles. (1988) Substrate specificity of nicotinamide methyltransferase isolated from porcine liver. Archives of Biochemistry and Biophysics 260:2, pages 601-608.
Crossref
Kenneth C. Cundy, C.Steven Godin & Peter A. Crooks. (1985) Stereospecific in vitro N-methylation of nicotine in guinea pig tissues by an S-adenosylmethionine-dependent N-methyltransferase. Biochemical Pharmacology 34:2, pages 281-284.
Crossref
K.C. Cundy & P.A. Crooks. (1984) High-performance liquid chromatographic method for the determination of N-methylated metabolites of nicotine. Journal of Chromatography B: Biomedical Sciences and Applications 306, pages 291-301.
Crossref
. 1984. Comprehensive Heterocyclic Chemistry. Comprehensive Heterocyclic Chemistry 673 731 .
L.A. Damani & D.E. Case. 1984. Comprehensive Heterocyclic Chemistry. Comprehensive Heterocyclic Chemistry 223 246 .
A.G. Renwick. 1983. Biological Basis of Detoxication. Biological Basis of Detoxication 151 179 .
M.S Shaker, P.A Crooks & L.A Damani. (1982) High-performance liquid chromatographic analysis of the in vivo metabolites of [14C]pyridine. Journal of Chromatography A 237:3, pages 489-495.
Crossref
JOHN CALDWELL. 1982. Metabolic Basis of Detoxication. Metabolic Basis of Detoxication 291 306 .

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