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Xenobiotica
the fate of foreign compounds in biological systems
Volume 10, 1980 - Issue 4
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Research Article

The metabolism of ellagic acid in the rat

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Pages 247-256 | Received 06 Aug 1979, Published online: 22 Sep 2008

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Mengwei Zhang, Shumao Cui, Bingyong Mao, Qiuxiang Zhang, Jianxin Zhao, Hao Zhang, Xin Tang & Wei Chen. (2023) Ellagic acid and intestinal microflora metabolite urolithin A: A review on its sources, metabolic distribution, health benefits, and biotransformation. Critical Reviews in Food Science and Nutrition 63:24, pages 6900-6922.
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Yantao Yin, Remigio Martínez, Wangang Zhang & Mario Estévez. (2023) Crosstalk between dietary pomegranate and gut microbiota: evidence of health benefits. Critical Reviews in Food Science and Nutrition 0:0, pages 1-27.
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Yuandi Lei, Tianyi Jiang, Liqin He, Yanping Liu, Zhanbing Sun, Weihua Deng, Lian Huang & Zhaohui Zhang. (2022) Ellagic acid attenuates beryllium sulphate-induced oxidative stress and histopathological alterations of spleen in rats. Pharmaceutical Biology 60:1, pages 1047-1054.
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Mohammad Yahya Karimi, Iman Fatemi, Heibatullah Kalantari, Mohammad Amin Mombeini, Saeed Mehrzadi & Mehdi Goudarzi. (2020) Ellagic Acid Prevents Oxidative Stress, Inflammation, and Histopathological Alterations in Acrylamide-Induced Hepatotoxicity in Wistar Rats. Journal of Dietary Supplements 17:6, pages 651-662.
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Mehdi Goudarzi, Mohammad Amin Mombeini, Iman Fatemi, Azadeh Aminzadeh, Heibatullah Kalantari, Ali Nesari, Hossein Najafzadehvarzi & Saeed Mehrzadi. (2019) Neuroprotective effects of Ellagic acid against acrylamide-induced neurotoxicity in rats. Neurological Research 41:5, pages 419-428.
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Coskun Usta, Semir Ozdemir, Michele Schiariti & Paolo Emilio Puddu. (2013) The pharmacological use of ellagic acid-rich pomegranate fruit. International Journal of Food Sciences and Nutrition 64:7, pages 907-913.
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Essi Päivärinta, Anne-Maria Pajari, Riitta Törrönen & Marja Mutanen. (2006) Ellagic Acid and Natural Sources of Ellagitannins as Possible Chemopreventive Agents Against Intestinal Tumorigenesis in the Min Mouse. Nutrition and Cancer 54:1, pages 79-83.
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Mineka YOSHIMURA, Yuko WATANABE, Kouichi KASAI, Jun YAMAKOSHI & Takuro KOGA. (2005) Inhibitory Effect of an Ellagic Acid-Rich Pomegranate Extract on Tyrosinase Activity and Ultraviolet-Induced Pigmentation. Bioscience, Biotechnology, and Biochemistry 69:12, pages 2368-2373.
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C. T. Allen, M. M. Peden‐Adams, J. EuDaly & D. E. Keil. (2003) Subchronic Exposure to Ellagic Acid Impairs Cytotoxic T‐Cell Function and Suppresses Humoral Immunity in Mice. Immunopharmacology and Immunotoxicology 25:3, pages 409-422.
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Amita Kaul & L. Khanduja. (1998) Polyphenols inhibit promotional phase of tumorigenesis: Relevance of superoxide radicals. Nutrition and Cancer 32:2, pages 81-85.
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Robert W. Teel & Ronald M. Martin. (1988) Disposition of the plant phenol ellagic acid in the mouse following oral administration by gavage. Xenobiotica 18:4, pages 397-405.
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Articles from other publishers (62)

Giada Benedetti, Federica Zabini, Luca Tagliavento, Francesco Meneguzzo, Vincenzo Calderone & Lara Testai. (2023) An Overview of the Health Benefits, Extraction Methods and Improving the Properties of Pomegranate. Antioxidants 12:7, pages 1351.
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Jing Zhang, Yang Lv, Jing Zhang, Wen-Jin Shi, Xu-Yan Guo, Jing-Jing Xu, Peng-Pu Wang, Xue-Tai Chen, Lin-Han Xiang, Feng Xu, Xuan Wang & Shao-Qing Cai. (2022) Metabolism of Paeoniae Radix Rubra and its 14 constituents in mice. Frontiers in Pharmacology 13.
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Zhi-hao Yu, Mei Cao, Yuan-xiao Wang, Shi-ying Yan, Li-ting Qing, Cheng-meng Wu, Shu Li, Tian-yi Li, Qian Chen & Jian Zhao. (2022) Urolithin A Attenuates Helicobacter pylori -Induced Damage In Vivo . Journal of Agricultural and Food Chemistry 70:38, pages 11981-11993.
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H. Surya Prakash Rao, M. Prabakaran & Nandurka Muthanna. (2022) Synthesis of 7-hydroxydibenzopyran-6-ones via benzannulation of coumarins . Organic & Biomolecular Chemistry 20:34, pages 6905-6914.
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Haoyu Mi, Shu Liu, Yang Hai, Guang Yang, Jing Lu, Fuxiang He, Yaling Zhao, Mengjie Xia, Xiaoyue Hou & Yaowei Fang. (2022) Lactococcus garvieae FUA009, a Novel Intestinal Bacterium Capable of Producing the Bioactive Metabolite Urolithin A from Ellagic Acid. Foods 11:17, pages 2621.
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Michael B. Scott, Amy K. Styring & James S. O. McCullagh. (2022) Polyphenols: Bioavailability, Microbiome Interactions and Cellular Effects on Health in Humans and Animals. Pathogens 11:7, pages 770.
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Oskar Wiśniewski, Aleksander Rajczewski, Agnieszka Szumigała & Magdalena Gibas-Dorna. (2021) Diet-Induced Adipocyte Browning. Polish Journal of Food and Nutrition Sciences, pages 353-381.
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Davide D’Amico, Pénélope A. Andreux, Pamela Valdés, Anurag Singh, Chris Rinsch & Johan Auwerx. (2021) Impact of the Natural Compound Urolithin A on Health, Disease, and Aging. Trends in Molecular Medicine 27:7, pages 687-699.
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Ahkam Saddam Seyed Hameed, Parkash Singh Rawat, Xiangfeng Meng & Weifeng Liu. (2020) Biotransformation of dietary phytoestrogens by gut microbes: A review on bidirectional interaction between phytoestrogen metabolism and gut microbiota. Biotechnology Advances 43, pages 107576.
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Gulsum Muku, Iain Murray, Juan Espín & Gary Perdew. (2018) Urolithin A Is a Dietary Microbiota-Derived Human Aryl Hydrocarbon Receptor Antagonist. Metabolites 8:4, pages 86.
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Saeed Mehrzadi, Iman Fatemi, Ali Reza Malayeri, Ali Khodadadi, Fatemeh Mohammadi, Esrafil Mansouri, Mohammad Rashno & Mehdi Goudarzi. (2018) Ellagic acid mitigates sodium arsenite-induced renal and hepatic toxicity in male Wistar rats. Pharmacological Reports 70:4, pages 712-719.
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Mehdi Goudarzi, Iman Fatemi, Amir Siahpoosh, Seyed Hashem Sezavar, Esrafil Mansouri & Saeed Mehrzadi. (2018) Protective Effect of Ellagic Acid Against Sodium Arsenite-Induced Cardio- and Hematotoxicity in Rats. Cardiovascular Toxicology 18:4, pages 337-345.
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Shang-Ta Wang, Chien-Te Chou & Nan-Wei Su. (2017) A food-grade self-nanoemulsifying delivery system for enhancing oral bioavailability of ellagic acid. Journal of Functional Foods 34, pages 207-215.
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Francisco A. Tomás-Barberán, Antonio González-Sarrías, Rocío García-Villalba, María A. Núñez-Sánchez, María V. Selma, María T. García-Conesa & Juan Carlos Espín. (2017) Urolithins, the rescue of “old” metabolites to understand a “new” concept: Metabotypes as a nexus among phenolic metabolism, microbiota dysbiosis, and host health status. Molecular Nutrition & Food Research 61:1, pages 1500901.
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Jakub P. Piwowarski, Sebastian Granica, Joanna Stefańska & Anna K. Kiss. (2016) Differences in Metabolism of Ellagitannins by Human Gut Microbiota ex Vivo Cultures. Journal of Natural Products 79:12, pages 3022-3030.
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Elitsa L. Pavlova, Nikolay N. Zografov & Lora S. Simeonova. (2016) Comparative study on the antioxidant capacities of synthetic influenza inhibitors and ellagic acid in model systems. Biomedicine & Pharmacotherapy 83, pages 755-762.
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Qi-an Han, Chunhong Yan, Lingfang Wang, Guanghui Li, Yunfeng Xu & Xiaodong Xia. (2016) Urolithin A attenuates ox-LDL-induced endothelial dysfunction partly by modulating microRNA-27 and ERK/PPAR-γ pathway. Molecular Nutrition & Food Research 60:9, pages 1933-1943.
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Sanmuga Priya Ekambaram, Senthamil Selvan Perumal & Ajay Balakrishnan. (2016) Scope of Hydrolysable Tannins as Possible Antimicrobial Agent. Phytotherapy Research 30:7, pages 1035-1045.
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Ya. L. Garazd & M. M. Garazd. (2016) Natural Dibenzo[b,d]Pyran-6-Ones: Structural Diversity and Biological Activity. Chemistry of Natural Compounds 52:1, pages 1-18.
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Sang Wook Park, Min Jung Kwon, Ji Young Yoo, Hwa-Jung Choi & Young-Joon Ahn. (2014) Antiviral activity and possible mode of action of ellagic acid identified in Lagerstroemia speciosa leaves toward human rhinoviruses. BMC Complementary and Alternative Medicine 14:1.
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Linlin Yan, Peipei Yin, Chao Ma & Yujun Liu. (2014) Method Development and Validation for Pharmacokinetic and Tissue Distributions of Ellagic Acid Using Ultrahigh Performance Liquid Chromatography-Tandem Mass Spectrometry (UPLC-MS/MS). Molecules 19:11, pages 18923-18935.
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Lei Gu, Wen-sheng Deng, Ye Liu, Chun-hui Jiang, Long-ci Sun, Xiao-fei Sun, Qing Xu & Hong Zhou. (2014) Ellagic acid protects Lipopolysaccharide/d-galactosamine-induced acute hepatic injury in mice. International Immunopharmacology 22:2, pages 341-345.
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Jing-Yi Ma, Xuelin Zhou, Jie Fu, Tao Hu, Penelope M.Y. Or, Ru Feng, Chi-Yu He, Wen-Jing Chen, Xianfeng Zhang, Yangchao Chen, Yan Wang & John H.K. Yeung. (2014) Metabolite profiling analysis of FR429, an ellagitannin purified from Polygonum capitatum, in rat and human liver microsomes, cytosol and rat primary hepatocytes in vitro. Chemico-Biological Interactions 220, pages 33-40.
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Jian Xiao, Yuye Chen, Shuai Zhu, Liang Wang, Lubin Xu & Hongtao Wei. (2014) Diversified Construction of Chromeno[3,4‐ c ]pyridin‐5‐one and Benzo[ c ]chromen‐6‐one Derivatives by Domino Reaction of 4‐Alkynyl‐2‐oxo‐2 H ‐chromene‐3‐carbaldehydes . Advanced Synthesis & Catalysis 356:8, pages 1835-1845.
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Soo‐Jin Choi. 2014. Nano‐ and Microencapsulation for Foods. Nano‐ and Microencapsulation for Foods 345 362 .
Uma Rani P.Rushendhiran Kesavan, Raghu Ganugula, Avaneesh T.Uday Kumar P.G. Bhanuprakash Reddy & Madhulika Dixit. (2013) Ellagic acid inhibits PDGF-BB-induced vascular smooth muscle cell proliferation and prevents atheroma formation in streptozotocin-induced diabetic rats. The Journal of Nutritional Biochemistry 24:11, pages 1830-1839.
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Juan Carlos Espín, Mar Larrosa, María Teresa García-Conesa & Francisco Tomás-Barberán. (2013) Biological Significance of Urolithins, the Gut Microbial Ellagic Acid-Derived Metabolites: The Evidence So Far. Evidence-Based Complementary and Alternative Medicine 2013, pages 1-15.
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Daniely Cornélio Favarin, Maxelle Martins Teixeira, Ednéia Lemos de Andrade, Claudiney de Freitas Alves, Javier Emilio Lazo Chica, Carlos Artério Sorgi, Lúcia Helena Faccioli & Alexandre Paula Rogerio. (2013) Anti-Inflammatory Effects of Ellagic Acid on Acute Lung Injury Induced by Acid in Mice. Mediators of Inflammation 2013, pages 1-13.
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Andrea Berni, Maria Rosaria Grossi, Gaetano Pepe, Silvia Filippi, Sowndarya Muthukumar, Cristiano Papeschi, Adayapalam T. Natarajan & Fabrizio Palitti. (2012) Protective effect of ellagic acid (EA) on micronucleus formation induced by N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) in mammalian cells, in in vitro assays and in vivo. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 746:1, pages 60-65.
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Lydia Kaume, Luke R. Howard & Latha Devareddy. (2011) The Blackberry Fruit: A Review on Its Composition and Chemistry, Metabolism and Bioavailability, and Health Benefits. Journal of Agricultural and Food Chemistry 60:23, pages 5716-5727.
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Ian R. Pottie, Penchal Reddy Nandaluru, Wendy L. Benoit, David O. Miller, Louise N. Dawe & Graham J. Bodwell. (2011) Synthesis of 6 H -Dibenzo[ b , d ]pyran-6-ones Using the Inverse Electron Demand Diels–Alder Reaction . The Journal of Organic Chemistry 76:21, pages 9015-9030.
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J.M. Landete. (2011) Ellagitannins, ellagic acid and their derived metabolites: A review about source, metabolism, functions and health. Food Research International 44:5, pages 1150-1160.
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Rocío González-Barrio, Pilar Truchado, Hideyuki Ito, Juan C. Espín & Francisco A. Tomás-Barberán. (2011) UV and MS Identification of Urolithins and Nasutins, the Bioavailable Metabolites of Ellagitannins and Ellagic Acid in Different Mammals. Journal of Agricultural and Food Chemistry 59:4, pages 1152-1162.
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Hideyuki Ito, Ayumu Iguchi & Tsutomu Hatano. (2007) Identification of Urinary and Intestinal Bacterial Metabolites of Ellagitannin Geraniin in Rats. Journal of Agricultural and Food Chemistry 56:2, pages 393-400.
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