Citations (74)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (12)
Mengwei Zhang, Shumao Cui, Bingyong Mao, Qiuxiang Zhang, Jianxin Zhao, Hao Zhang, Xin Tang & Wei Chen. (2023) Ellagic acid and intestinal microflora metabolite urolithin A: A review on its sources, metabolic distribution, health benefits, and biotransformation. Critical Reviews in Food Science and Nutrition 63:24, pages 6900-6922.
Read now
Read now
Yantao Yin, Remigio Martínez, Wangang Zhang & Mario Estévez. (2023) Crosstalk between dietary pomegranate and gut microbiota: evidence of health benefits. Critical Reviews in Food Science and Nutrition 0:0, pages 1-27.
Read now
Read now
Yuandi Lei, Tianyi Jiang, Liqin He, Yanping Liu, Zhanbing Sun, Weihua Deng, Lian Huang & Zhaohui Zhang. (2022) Ellagic acid attenuates beryllium sulphate-induced oxidative stress and histopathological alterations of spleen in rats. Pharmaceutical Biology 60:1, pages 1047-1054.
Read now
Read now
Mohammad Yahya Karimi, Iman Fatemi, Heibatullah Kalantari, Mohammad Amin Mombeini, Saeed Mehrzadi & Mehdi Goudarzi. (2020) Ellagic Acid Prevents Oxidative Stress, Inflammation, and Histopathological Alterations in Acrylamide-Induced Hepatotoxicity in Wistar Rats. Journal of Dietary Supplements 17:6, pages 651-662.
Read now
Read now
Mehdi Goudarzi, Mohammad Amin Mombeini, Iman Fatemi, Azadeh Aminzadeh, Heibatullah Kalantari, Ali Nesari, Hossein Najafzadehvarzi & Saeed Mehrzadi. (2019) Neuroprotective effects of Ellagic acid against acrylamide-induced neurotoxicity in rats. Neurological Research 41:5, pages 419-428.
Read now
Read now
Coskun Usta, Semir Ozdemir, Michele Schiariti & Paolo Emilio Puddu. (2013) The pharmacological use of ellagic acid-rich pomegranate fruit. International Journal of Food Sciences and Nutrition 64:7, pages 907-913.
Read now
Read now
Essi Päivärinta, Anne-Maria Pajari, Riitta Törrönen & Marja Mutanen. (2006) Ellagic Acid and Natural Sources of Ellagitannins
as Possible Chemopreventive Agents Against Intestinal Tumorigenesis in the Min Mouse. Nutrition and Cancer 54:1, pages 79-83.
Read now
Read now
Mineka YOSHIMURA, Yuko WATANABE, Kouichi KASAI, Jun YAMAKOSHI & Takuro KOGA. (2005) Inhibitory Effect of an Ellagic Acid-Rich Pomegranate Extract on Tyrosinase Activity and Ultraviolet-Induced Pigmentation. Bioscience, Biotechnology, and Biochemistry 69:12, pages 2368-2373.
Read now
Read now
C. T. Allen, M. M. Peden‐Adams, J. EuDaly & D. E. Keil. (2003) Subchronic Exposure to Ellagic Acid Impairs Cytotoxic T‐Cell Function and Suppresses Humoral Immunity in Mice. Immunopharmacology and Immunotoxicology 25:3, pages 409-422.
Read now
Read now
Amita Kaul & L. Khanduja. (1998) Polyphenols inhibit promotional phase of tumorigenesis: Relevance of superoxide radicals. Nutrition and Cancer 32:2, pages 81-85.
Read now
Read now
Robert W. Teel & Ronald M. Martin. (1988) Disposition of the plant phenol ellagic acid in the mouse following oral administration by gavage. Xenobiotica 18:4, pages 397-405.
Read now
Read now
HaroldL. Newmark. (1985) A hypothesis for dietary components as blocking agents of chemical carcinogenesis: Plant phenolics and pyrrole pigments. Nutrition and Cancer 6:1, pages 58-70.
Read now
Read now
Articles from other publishers (62)
Giada Benedetti, Federica Zabini, Luca Tagliavento, Francesco Meneguzzo, Vincenzo Calderone & Lara Testai. (2023) An Overview of the Health Benefits, Extraction Methods and Improving the Properties of Pomegranate. Antioxidants 12:7, pages 1351.
Crossref
Crossref
Jing Zhang, Yang Lv, Jing Zhang, Wen-Jin Shi, Xu-Yan Guo, Jing-Jing Xu, Peng-Pu Wang, Xue-Tai Chen, Lin-Han Xiang, Feng Xu, Xuan Wang & Shao-Qing Cai. (2022) Metabolism of Paeoniae Radix Rubra and its 14 constituents in mice. Frontiers in Pharmacology 13.
Crossref
Crossref
Zhi-hao Yu, Mei Cao, Yuan-xiao Wang, Shi-ying Yan, Li-ting Qing, Cheng-meng Wu, Shu Li, Tian-yi Li, Qian Chen & Jian Zhao. (2022)
Urolithin A Attenuates
Helicobacter pylori
-Induced Damage In Vivo
. Journal of Agricultural and Food Chemistry 70:38, pages 11981-11993.
Crossref
Crossref
H. Surya Prakash Rao, M. Prabakaran & Nandurka Muthanna. (2022)
Synthesis of 7-hydroxydibenzopyran-6-ones
via
benzannulation of coumarins
. Organic & Biomolecular Chemistry 20:34, pages 6905-6914.
Crossref
Crossref
Haoyu Mi, Shu Liu, Yang Hai, Guang Yang, Jing Lu, Fuxiang He, Yaling Zhao, Mengjie Xia, Xiaoyue Hou & Yaowei Fang. (2022) Lactococcus garvieae FUA009, a Novel Intestinal Bacterium Capable of Producing the Bioactive Metabolite Urolithin A from Ellagic Acid. Foods 11:17, pages 2621.
Crossref
Crossref
Michael B. Scott, Amy K. Styring & James S. O. McCullagh. (2022) Polyphenols: Bioavailability, Microbiome Interactions and Cellular Effects on Health in Humans and Animals. Pathogens 11:7, pages 770.
Crossref
Crossref
Oskar Wiśniewski, Aleksander Rajczewski, Agnieszka Szumigała & Magdalena Gibas-Dorna. (2021) Diet-Induced Adipocyte Browning. Polish Journal of Food and Nutrition Sciences, pages 353-381.
Crossref
Crossref
Davide D’Amico, Pénélope A. Andreux, Pamela Valdés, Anurag Singh, Chris Rinsch & Johan Auwerx. (2021) Impact of the Natural Compound Urolithin A on Health, Disease, and Aging. Trends in Molecular Medicine 27:7, pages 687-699.
Crossref
Crossref
Ahkam Saddam Seyed Hameed, Parkash Singh Rawat, Xiangfeng Meng & Weifeng Liu. (2020) Biotransformation of dietary phytoestrogens by gut microbes: A review on bidirectional interaction between phytoestrogen metabolism and gut microbiota. Biotechnology Advances 43, pages 107576.
Crossref
Crossref
Gulsum Muku, Iain Murray, Juan Espín & Gary Perdew. (2018) Urolithin A Is a Dietary Microbiota-Derived Human Aryl Hydrocarbon Receptor Antagonist. Metabolites 8:4, pages 86.
Crossref
Crossref
Saeed Mehrzadi, Iman Fatemi, Ali Reza Malayeri, Ali Khodadadi, Fatemeh Mohammadi, Esrafil Mansouri, Mohammad Rashno & Mehdi Goudarzi. (2018) Ellagic acid mitigates sodium arsenite-induced renal and hepatic toxicity in male Wistar rats. Pharmacological Reports 70:4, pages 712-719.
Crossref
Crossref
Mehdi Goudarzi, Iman Fatemi, Amir Siahpoosh, Seyed Hashem Sezavar, Esrafil Mansouri & Saeed Mehrzadi. (2018) Protective Effect of Ellagic Acid Against Sodium Arsenite-Induced Cardio- and Hematotoxicity in Rats. Cardiovascular Toxicology 18:4, pages 337-345.
Crossref
Crossref
Shang-Ta Wang, Chien-Te Chou & Nan-Wei Su. (2017) A food-grade self-nanoemulsifying delivery system for enhancing oral bioavailability of ellagic acid. Journal of Functional Foods 34, pages 207-215.
Crossref
Crossref
Francisco A. Tomás-Barberán, Antonio González-Sarrías, Rocío García-Villalba, María A. Núñez-Sánchez, María V. Selma, María T. García-Conesa & Juan Carlos Espín. (2017) Urolithins, the rescue of “old” metabolites to understand a “new” concept: Metabotypes as a nexus among phenolic metabolism, microbiota dysbiosis, and host health status. Molecular Nutrition & Food Research 61:1, pages 1500901.
Crossref
Crossref
Jakub P. Piwowarski, Sebastian Granica, Joanna Stefańska & Anna K. Kiss. (2016) Differences in Metabolism of Ellagitannins by Human Gut Microbiota ex Vivo Cultures. Journal of Natural Products 79:12, pages 3022-3030.
Crossref
Crossref
Elitsa L. Pavlova, Nikolay N. Zografov & Lora S. Simeonova. (2016) Comparative study on the antioxidant capacities of synthetic influenza inhibitors and ellagic acid in model systems. Biomedicine & Pharmacotherapy 83, pages 755-762.
Crossref
Crossref
Qi-an Han, Chunhong Yan, Lingfang Wang, Guanghui Li, Yunfeng Xu & Xiaodong Xia. (2016) Urolithin A attenuates ox-LDL-induced endothelial dysfunction partly by modulating microRNA-27 and ERK/PPAR-γ pathway. Molecular Nutrition & Food Research 60:9, pages 1933-1943.
Crossref
Crossref
Sanmuga Priya Ekambaram, Senthamil Selvan Perumal & Ajay Balakrishnan. (2016) Scope of Hydrolysable Tannins as Possible Antimicrobial Agent. Phytotherapy Research 30:7, pages 1035-1045.
Crossref
Crossref
Ya. L. Garazd & M. M. Garazd. (2016) Natural Dibenzo[b,d]Pyran-6-Ones: Structural Diversity and Biological Activity. Chemistry of Natural Compounds 52:1, pages 1-18.
Crossref
Crossref
Sang Wook Park, Min Jung Kwon, Ji Young Yoo, Hwa-Jung Choi & Young-Joon Ahn. (2014) Antiviral activity and possible mode of action of ellagic acid identified in Lagerstroemia speciosa leaves toward human rhinoviruses. BMC Complementary and Alternative Medicine 14:1.
Crossref
Crossref
Linlin Yan, Peipei Yin, Chao Ma & Yujun Liu. (2014) Method Development and Validation for Pharmacokinetic and Tissue Distributions of Ellagic Acid Using Ultrahigh Performance Liquid Chromatography-Tandem Mass Spectrometry (UPLC-MS/MS). Molecules 19:11, pages 18923-18935.
Crossref
Crossref
Lei Gu, Wen-sheng Deng, Ye Liu, Chun-hui Jiang, Long-ci Sun, Xiao-fei Sun, Qing Xu & Hong Zhou. (2014) Ellagic acid protects Lipopolysaccharide/d-galactosamine-induced acute hepatic injury in mice. International Immunopharmacology 22:2, pages 341-345.
Crossref
Crossref
Jing-Yi Ma, Xuelin Zhou, Jie Fu, Tao Hu, Penelope M.Y. Or, Ru Feng, Chi-Yu He, Wen-Jing Chen, Xianfeng Zhang, Yangchao Chen, Yan Wang & John H.K. Yeung. (2014) Metabolite profiling analysis of FR429, an ellagitannin purified from Polygonum capitatum, in rat and human liver microsomes, cytosol and rat primary hepatocytes in vitro. Chemico-Biological Interactions 220, pages 33-40.
Crossref
Crossref
Jian Xiao, Yuye Chen, Shuai Zhu, Liang Wang, Lubin Xu & Hongtao Wei. (2014)
Diversified Construction of Chromeno[3,4‐
c
]pyridin‐5‐one and Benzo[
c
]chromen‐6‐one Derivatives by Domino Reaction of 4‐Alkynyl‐2‐oxo‐2
H
‐chromene‐3‐carbaldehydes
. Advanced Synthesis & Catalysis 356:8, pages 1835-1845.
Crossref
Crossref
Soo‐Jin Choi. 2014. Nano‐ and Microencapsulation for Foods. Nano‐ and Microencapsulation for Foods
345
362
.
Uma Rani P.Rushendhiran Kesavan, Raghu Ganugula, Avaneesh T.Uday Kumar P.G. Bhanuprakash Reddy & Madhulika Dixit. (2013) Ellagic acid inhibits PDGF-BB-induced vascular smooth muscle cell proliferation and prevents atheroma formation in streptozotocin-induced diabetic rats. The Journal of Nutritional Biochemistry 24:11, pages 1830-1839.
Crossref
Crossref
Juan Carlos Espín, Mar Larrosa, María Teresa García-Conesa & Francisco Tomás-Barberán. (2013) Biological Significance of Urolithins, the Gut Microbial Ellagic Acid-Derived Metabolites: The Evidence So Far. Evidence-Based Complementary and Alternative Medicine 2013, pages 1-15.
Crossref
Crossref
Daniely Cornélio Favarin, Maxelle Martins Teixeira, Ednéia Lemos de Andrade, Claudiney de Freitas Alves, Javier Emilio Lazo Chica, Carlos Artério Sorgi, Lúcia Helena Faccioli & Alexandre Paula Rogerio. (2013) Anti-Inflammatory Effects of Ellagic Acid on Acute Lung Injury Induced by Acid in Mice. Mediators of Inflammation 2013, pages 1-13.
Crossref
Crossref
Andrea Berni, Maria Rosaria Grossi, Gaetano Pepe, Silvia Filippi, Sowndarya Muthukumar, Cristiano Papeschi, Adayapalam T. Natarajan & Fabrizio Palitti. (2012) Protective effect of ellagic acid (EA) on micronucleus formation induced by N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) in mammalian cells, in in vitro assays and in vivo. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 746:1, pages 60-65.
Crossref
Crossref
Lydia Kaume, Luke R. Howard & Latha Devareddy. (2011) The Blackberry Fruit: A Review on Its Composition and Chemistry, Metabolism and Bioavailability, and Health Benefits. Journal of Agricultural and Food Chemistry 60:23, pages 5716-5727.
Crossref
Crossref
Ian R. Pottie, Penchal Reddy Nandaluru, Wendy L. Benoit, David O. Miller, Louise N. Dawe & Graham J. Bodwell. (2011)
Synthesis of 6
H
-Dibenzo[
b
,
d
]pyran-6-ones Using the Inverse Electron Demand Diels–Alder Reaction
. The Journal of Organic Chemistry 76:21, pages 9015-9030.
Crossref
Crossref
J.M. Landete. (2011) Ellagitannins, ellagic acid and their derived metabolites: A review about source, metabolism, functions and health. Food Research International 44:5, pages 1150-1160.
Crossref
Crossref
Rocío González-Barrio, Pilar Truchado, Hideyuki Ito, Juan C. Espín & Francisco A. Tomás-Barberán. (2011) UV and MS Identification of Urolithins and Nasutins, the Bioavailable Metabolites of Ellagitannins and Ellagic Acid in Different Mammals. Journal of Agricultural and Food Chemistry 59:4, pages 1152-1162.
Crossref
Crossref
Mar Larrosa, María T. García-Conesa, Juan C. Espín & Francisco A. Tomás-Barberán. (2010) Ellagitannins, ellagic acid and vascular health. Molecular Aspects of Medicine 31:6, pages 513-539.
Crossref
Crossref
Gary Williamson & Michael N. Clifford. (2010) Colonic metabolites of berry polyphenols: the missing link to biological activity?. British Journal of Nutrition 104:S3, pages S48-S66.
Crossref
Crossref
Rocío González-Barrio, Gina Borges, William Mullen & Alan Crozier. (2010) Bioavailability of Anthocyanins and Ellagitannins Following Consumption of Raspberries by Healthy Humans and Subjects with an Ileostomy. Journal of Agricultural and Food Chemistry 58:7, pages 3933-3939.
Crossref
Crossref
Takashi Yoshida, Yoshiaki Amakura & Morio Yoshimura. (2010) Structural Features and Biological Properties of Ellagitannins in Some Plant Families of the Order Myrtales. International Journal of Molecular Sciences 11:1, pages 79-106.
Crossref
Crossref
Venkatesh Murugan, Kakali Mukherjee, Kuntal Maiti & Pulok K. Mukherjee. (2009) Enhanced Oral Bioavailability and Antioxidant Profile of Ellagic Acid by Phospholipids. Journal of Agricultural and Food Chemistry 57:11, pages 4559-4565.
Crossref
Crossref
Susan J. Zunino, David H. Storms, Yanjun Zhang & Navindra P. Seeram. (2009) Growth arrest and induction of apoptosis in high-risk leukemia cells by strawberry components in vitro. Journal of Functional Foods 1:2, pages 153-160.
Crossref
Crossref
Anna-Marja Aura. (2008) Microbial metabolism of dietary phenolic compounds in the colon. Phytochemistry Reviews 7:3, pages 407-429.
Crossref
Crossref
María Azorín-Ortuño, Cristina Urbán, José J. Cerón, Fernando Tecles, Angel Gil-Izquierdo, Francisco J. Pallarés, Francisco A. Tomás-Barberán & Juan Carlos Espín. (2008) Safety Evaluation of an Oak-Flavored Milk Powder Containing Ellagitannins upon Oral Administration in the Rat. Journal of Agricultural and Food Chemistry 56:8, pages 2857-2865.
Crossref
Crossref
Hideyuki Ito, Ayumu Iguchi & Tsutomu Hatano. (2007) Identification of Urinary and Intestinal Bacterial Metabolites of Ellagitannin Geraniin in Rats. Journal of Agricultural and Food Chemistry 56:2, pages 393-400.
Crossref
Crossref
K. Sonaje, J. L. Italia, G. Sharma, V. Bhardwaj, K. Tikoo & M. N. V. Ravi Kumar. (2007) Development of Biodegradable Nanoparticles for Oral Delivery of Ellagic Acid and Evaluation of Their Antioxidant Efficacy Against Cyclosporine A-Induced Nephrotoxicity in Rats. Pharmaceutical Research 24:5, pages 899-908.
Crossref
Crossref
Begoña Cerdá, Francisco A. Tomás-Barberán & Juan Carlos Espín. (2004) Metabolism of Antioxidant and Chemopreventive Ellagitannins from Strawberries, Raspberries, Walnuts, and Oak-Aged Wine in Humans: Identification of Biomarkers and Individual Variability. Journal of Agricultural and Food Chemistry 53:2, pages 227-235.
Crossref
Crossref
Jules Beekwilder, Robert D. Hall & C.H. De Ric Vos. (2008) Identification and dietary relevance of antioxidants from raspberry. BioFactors 23:4, pages 197-205.
Crossref
Crossref
Navindra P. Seeram, Rupo Lee & David Heber. (2004) Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juice. Clinica Chimica Acta 348:1-2, pages 63-68.
Crossref
Crossref
Fan Lei, Dong-Ming Xing, Lan Xiang, Yu-Nan Zhao, Wei Wang, Lu-Jun Zhang & Li-Jun Du. (2003) Pharmacokinetic study of ellagic acid in rat after oral administration of pomegranate leaf extract. Journal of Chromatography B 796:1, pages 189-194.
Crossref
Crossref
Begoña Cerdá, José J. Cerón, Francisco A. Tomás-Barberán & Juan Carlos Espín. (2003) Repeated Oral Administration of High Doses of the Pomegranate Ellagitannin Punicalagin to Rats for 37 Days Is Not Toxic. Journal of Agricultural and Food Chemistry 51:11, pages 3493-3501.
Crossref
Crossref
Leslie Wada & Boxin Ou. (2002) Antioxidant Activity and Phenolic Content of Oregon Caneberries. Journal of Agricultural and Food Chemistry 50:12, pages 3495-3500.
Crossref
Crossref
Luisella Verotta, Mario Dell'Agli, Andrea Giolito, Marco Guerrini, Pierre Cabalion & Enrica Bosisio. (2001)
In Vitro Antiplasmodial Activity of Extracts of
Tristaniopsis
Species and Identification of the Active Constituents: Ellagic Acid and 3,4,5-Trimethoxyphenyl-(6‘-
O
-galloyl)-
O
-β-
d
-glucopyranoside
. Journal of Natural Products 64:5, pages 603-607.
Crossref
Crossref
Michael N Clifford & Augustin Scalbert. (2000) Ellagitannins - nature, occurrence and dietary burden. Journal of the Science of Food and Agriculture 80:7, pages 1118-1125.
Crossref
Crossref
S Ahmed, A Rahman, M Saleem, M Athar & S Sultana. (2016) Ellagic acid ameliorates nickel induced biochemical alterations: diminution of oxidative stress. Human & Experimental Toxicology 18:11, pages 691-698.
Crossref
Crossref
R. G. S. Berlinck, T. Hatano, T. Okuda & T. YoshidaTakuo Okuda, Takashi Yoshida & Tsutomu Hatano. 1995. Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products. Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products
1
117
.
Sabhiya Majid, Krishan L. Khanduja, Rajinder K. Gandhi, Sanjay Kapur & Rati R. Sharma. (1991) Influence of ellagic acid on antioxidant defense system and lipid peroxidation in mice. Biochemical Pharmacology 42:7, pages 1441-1445.
Crossref
Crossref
Wenguang Zeng, Young-Hun Heur, Thomas H. Kinstle & Gary D. Stoner. (1991) Synthesis of [14CO]ellagic acid. Journal of Labelled Compounds and Radiopharmaceuticals 29:6, pages 657-666.
Crossref
Crossref
J. Elks & C. R. Ganellin. 1990. Dictionary of Drugs. Dictionary of Drugs
476
531
.
Takuji Tanaka, Hitoshi Iwata, Kenji Niwa, Yoshio Mori & Hideki Mori. (2005) Inhibitory Effect of Ellagic Acid on N‐2‐Fluorenylacetamide‐induced Liver Carcinogenesis in Male ACI/N Rats. Japanese Journal of Cancer Research 79:12, pages 1297-1303.
Crossref
Crossref
YIN-TAK WOO, DAVID Y. LAI, JOSEPH C. ARCOS & MARY F. ARGUS. 1988. Natural, Metal, Fiber, and Macromolecular Carcinogens. Natural, Metal, Fiber, and Macromolecular Carcinogens
3
616
.
Robert W. Teel. (1987) Distribution and metabolism of ellagic acid in the mouse following intraperitoneal administration. Cancer Letters 34:2, pages 165-171.
Crossref
Crossref
Robert W. Teel. (1986) Ellagic acid binding to DNA as a possible mechanism for its antimutagenic and anticarcinogenic action. Cancer Letters 30:3, pages 329-336.
Crossref
Crossref
P. Szabó, T. Ferenczy, J. Serfőző, J. Szejtli & A. Lipták. 1982. Proceedings of the First International Symposium on Cyclodextrins. Proceedings of the First International Symposium on Cyclodextrins
115
122
.
Vernon L. Singleton. 1981.
149
242
.