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Xenobiotica
the fate of foreign compounds in biological systems
Volume 10, 1980 - Issue 5
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Research Article

Metabolic fate of diethylstilbestrol in the Syrian golden hamster, a susceptible species for diethylstilbestrol carcinogenicity

R. Gottschlich Institut für Pharmakologie und Toxikologie, Universität Würzburg, Versbacher Straße 9, D-8700, Würzburg, FR, Germany
&
M. Metzler Institut für Pharmakologie und Toxikologie, Universität Würzburg, Versbacher Straße 9, D-8700, Würzburg, FR, Germany
Pages 317-327 | Received 10 Sep 1979, Published online: 22 Sep 2008

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GÜnter Blaich & Manfred Metzler. (1988) The effects of pretreatment with 7,8-benzoflavone on drug-metabolizing enzymes and diethylstilboestrol metabolism in male hamster liver microsomal preparations. Xenobiotica 18:2, pages 199-206.
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Manfred Metzler & L. J. Fischer. (1981) The Metabolism of Diethylstilbestro. Critical Reviews in Biochemistry 10:3, pages 171-212.
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Articles from other publishers (19)

Qian Liu, Weiwei Jin, Yan Zhu, Jieyun Zhou, Min Lu & Qian Zhang. (2012) Synthesis of 3′-methoxy-E-diethylstilbestrol and its analogs as tumor angiogenesis inhibitors. Steroids 77:5, pages 419-423.
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Taiko Oda, You So, Yoshihiro Sato, Noriaki Shimizu, Hiroshi Handa, Yukio Yasukochi & Tadashi Kasahara. (2003) Inhibition by (±)-indenestrol A of interferon gamma-stimulated nitric oxide formation in murine macrophage RAW 264.7 cells. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 534:1-2, pages 187-195.
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Satoko Ishikawa, Taiko Oda, Yoshihiro Sato & Masataka Mochizuki. (1996) Lack of mutagenicity of diethylstilbestrol metabolite and analog, (±)-indenestrols A and B, in bacterial assays. Mutation Research/Genetic Toxicology 368:3-4, pages 261-265.
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Taiko Oda, Yumiko Sakakibara, Ken Ichinoseki, Eriko Aizu-Yokota & Yoshihiro Sato. (1993) Effects of (+)-, (−)- and (±)-indenestrols A and B on microtubule distribution and cytotoxicity in Chinese hamster V79 cells. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 289:2, pages 223-230.
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Sara Antonia Li & Jonathan J. Li. 1992. Hormonal Carcinogenesis. Hormonal Carcinogenesis 110 117 .
M MetzlerG BlaichA M Tritscher. (1990) Role of metabolic activation in the carcinogenicity of estrogens: studies in an animal liver tumor model.. Environmental Health Perspectives 88, pages 117-121.
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K S Korach, K Chae, L A Levy, W L Duax & P J Sarver. (1989) Diethylstilbestrol Metabolites and Analogs. Journal of Biological Chemistry 264:10, pages 5642-5647.
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Günter Blaich & Manfred Metzler. (1988) Effect of pretreatment of male syrian golden hamsters with 7,8-benzoflavone and with diethylstilbestrol on P-450 isoenzyme activities and on microsomal diethylstilbestrol metabolism. Journal of Steroid Biochemistry 31:6, pages 971-978.
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Günter Blaich & Manfred Metzler. (1988) Effect of pretreatment with 7,8-benzoflavone and diethylstilbestrol on the hepatic metabolism of diethylstilbestrol in the male Syrian golden hamster in vivo. Biochemical Pharmacology 37:19, pages 3565-3570.
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N. M. Boyd & P. C. Reade. (1988) Factors associated with the development of neoplasia. Journal of Oral Pathology and Medicine 17:5, pages 202-207.
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Günter Blaich, Erich Pfaff & Manfred Metzler. (1987) Metabolism of diethylstilbestrol in hamster hepatocytes. Biochemical Pharmacology 36:19, pages 3135-3140.
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W L Duax, J F Griffin, C M Weeks & K S Korach. (1985) Molecular conformation, receptor binding, and hormone action of natural and synthetic estrogens and antiestrogens.. Environmental Health Perspectives 61, pages 111-121.
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Joachim G. Liehr & David A. Sirbasku. 1985. Tissue Culture of Epithelial Cells. Tissue Culture of Epithelial Cells 205 234 .
Regina Maydl & Manfred Metzler. (2005) Oxidative metabolites of diethylstilbestrol in the fetal Syrian golden hamster. Teratology 30:3, pages 351-357.
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Bruce E. Walker. 1984. Issues and Reviews in Teratology. Issues and Reviews in Teratology 157 187 .
Jelka Tomašić. 1983. Drug Metabolite Isolation and Determination. Drug Metabolite Isolation and Determination 149 160 .
Jacques Gilloteaux, Robert J. Paul & Alan W. Steggles. (1982) Upper genital tract abnormalities in the syrian hamster as a result ofin utero exposure to diethylstilbestrol. Virchows Archiv A Pathological Anatomy and Histopathology 398:2, pages 163-183.
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Paul Kleihues. 1981. Developmental Toxicology. Developmental Toxicology 211 246 .
J. H. Weisburger & G. M. Williams. 1982. Etiology: Chemical and Physical Carcinogenesis. Etiology: Chemical and Physical Carcinogenesis 241 333 .

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