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Xenobiotica
the fate of foreign compounds in biological systems
Volume 10, 1980 - Issue 6
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Research Article

The absorption, distribution and excretion of [14C]lormetazepam in dogs, rabbits, rats and rhesus monkeys

R. Girkin Department of Metabolism and Pharmacokinetics, Huntingdon Research Centre, Huntingdon, PE18 6ES, UK
,
G. A. Baldock Department of Metabolism and Pharmacokinetics, Huntingdon Research Centre, Huntingdon, PE18 6ES, UK
,
L. F. Chasseaud Department of Metabolism and Pharmacokinetics, Huntingdon Research Centre, Huntingdon, PE18 6ES, UK
,
M. Hümpel Department of Biodynamics, Schering AG, Berlin, West Germany
,
D. R. Hawkins Department of Metabolism and Pharmacokinetics, Huntingdon Research Centre, Huntingdon, PE18 6ES, UK
&
B. C. Mayo Department of Metabolism and Pharmacokinetics, Huntingdon Research Centre, Huntingdon, PE18 6ES, UK
Pages 401-411 | Received 30 Sep 1979, Published online: 22 Sep 2008

Citations (9)

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Read on this site (2)

Y. Tokuma, T. Fujiwara & H. Noguchi. (1987) Absorption, distribution and excretion of nilvadipine, a new dihydropyridine calcium antagonist, in rats and dogs. Xenobiotica 17:11, pages 1341-1349.
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B. C. Mayo, D. R. Hawkins, M. Hümpel, L. F. Chasseaud & R. Girkin. (1980) The biotransformation of [14C]lormetazepam in dogs, rabbits, rats and rhesus monkeys. Xenobiotica 10:6, pages 413-420.
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Articles from other publishers (7)

Reinhard Horowski. (2020) Dependence liability of lormetazepam: are all benzodiazepines equal? The case of the new i.v. lormetazepam for anesthetic procedures. Journal of Neural Transmission 127:8, pages 1107-1115.
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Yuan H Zhao, Michael H Abraham, Joelle Le, Anne Hersey, Chris N Luscombe, Gordon Beck, Brad Sherborne & Ian Cooper. (2003) Evaluation of rat intestinal absorption data and correlation with human intestinal absorption. European Journal of Medicinal Chemistry 38:3, pages 233-243.
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Kazuaki Shinomiya, Yuki Shigemoto, Chihiro Okuma, Mitsunobu Mio & Chiaki Kamei. (2003) Effects of short-acting hypnotics on sleep latency in rats placed on grid suspended over water. European Journal of Pharmacology 460:2-3, pages 139-144.
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Hartmund Wollweber. 2003. Ullmann's Encyclopedia of Industrial Chemistry. Ullmann's Encyclopedia of Industrial Chemistry.
M. Hildebrand, A. Hellstern, M. Hümpel, D. Hellenbrecht & R. Saller. (1990) Plasma levels and urinary excretion of lormetazepam in patients with liver cirrhosis and in healthy volunteers. European Journal of Drug Metabolism and Pharmacokinetics 15:1, pages 19-26.
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M. H�mpel, I. Stoppelli, S. Milia & E. Rainer. (1982) Pharmacokinetics and biotransformation of the new benzodiazepine, lormetazepam, in man. European Journal of Clinical Pharmacology 21:5, pages 421-425.
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M. Hümpel, V. Illi, W. Milius, H. Wendt & M. Kurowski. (1979) The pharmacokinetics and biotransformation of the new benzodiazepine lormetazepam in humans I. Absorption, distribution, elimination and metabolism of lormetazepam-5-14C. European Journal of Drug Metabolism and Pharmacokinetics 4:4, pages 237-243.
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