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Xenobiotica
the fate of foreign compounds in biological systems
Volume 10, 1980 - Issue 6
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Research Article

The combined toxicity of technical grade xylene and ethanol in the rat

E. Elovaara Institute of Occupational Health, Haartmaninkatu 1, SF-00290, Helsinki, 29, Finland
,
Y. Collan Institute of Occupational Health, Haartmaninkatu 1, SF-00290, Helsinki, 29, Finland
,
P. Pfäffli Institute of Occupational Health, Haartmaninkatu 1, SF-00290, Helsinki, 29, Finland
&
H. Vainio Institute of Occupational Health, Haartmaninkatu 1, SF-00290, Helsinki, 29, Finland
Pages 435-445 | Received 13 Nov 1979, Published online: 22 Sep 2008

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Anu Vaidyanathan, J. W.-D. Foy & Robert Schatz. (2003) Inhibition of Rat Respiratory-Tract Cytochrome P-450 Isozymes Following Inhalation of m -Xylene: Possible Role of Metabolites. Journal of Toxicology and Environmental Health, Part A 66:12, pages 1133-1143.
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Agneta Löf & Gunnar Johanson. (1998) Toxicokinetics of Organic Solvents: A Review of Modifying Factors. Critical Reviews in Toxicology 28:6, pages 571-650.
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Soo Hee Park, ThomasA. AuCoin, DianeM. Silverman & RobertA. Schatz. (1994) Time‐dependent effects of o‐xylene on rat lung and liver microsomal membrane structure and function. Journal of Toxicology and Environmental Health 43:4, pages 469-481.
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E. Elovaara, K. Engström, L. Häyri, T. Hase & A. Aitio. (1989) Metabolism of antipyrine and m-xylene in rats after prolonged pretreatment with xylene alone or xylene with ethanol, phenobarbital or 3-methylcholanthrene. Xenobiotica 19:9, pages 945-960.
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E. Elovaara, K. Engström, J. Nickels, A. Aito & H. Vainio. (1985) Biochemical and morphological effects of long-term inhalation exposure of rats to ethylbenzene. Xenobiotica 15:4, pages 299-308.
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K. Engström, E. Elovaara & A. Aitio. (1985) Metabolism of ethylbenzene in the rat during long-term intermittent inhalation exposure. Xenobiotica 15:4, pages 281-286.
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E. Elovaara. (1982) Dose-related effects of m-xylene inhalation on the xenobiotic metabolism of the rat. Xenobiotica 12:6, pages 345-352.
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Articles from other publishers (22)

. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 264 285 .
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 19 .
. 2002. The MAK-Collection for Occupational Health and Safety. The MAK-Collection for Occupational Health and Safety 1 318 .
. 2002. The MAK-Collection for Occupational Health and Safety. The MAK-Collection for Occupational Health and Safety 264 276 .
Takashi Kaneko, Jouji Horiuchi & Akio Sato. (2000) Development of a physiologically based pharmacokinetic model of organic solvent in rats. Pharmacological Research 42:5, pages 465-470.
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Mike Fay, Carol Eisenmann, Sanjivani Diwan & Christopher De Rosa. (2016) ATSDR Evaluation of Health Effects of Chemicals. V. Xylenes: Health Effects, Toxicokinetics, Human Exposure, and Environmental Fate. Toxicology and Industrial Health 14:5, pages 571-766.
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P. Pai, A. Stevenson, H. Mason & G. M. Bell. (1998) Occupational hydrocarbon exposure and nephrotoxicity: a cohort study and literature review.. Postgraduate Medical Journal 74:870, pages 225-228.
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Robin Fraser, Bruce R. Dobbs & George W. T. Rogers. (1995) Lipoproteins and the liver sieve: The role of the fenestrated sinusoidal endothelium in lipoprotein metabolism, atherosclerosis, and cirrhosis. Hepatology 21:3, pages 863-874.
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S. Padilla, D.L. Lyerly & C.N. Pope. (1992) Subacute ethanol consumption reverses p-xylene-induced decreases in axonal transport. Toxicology 75:2, pages 159-167.
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Justyna M. Wiśniewska-Knypl, Teresa Wrońska-Nofer, Jolanta Jajte & Urszula Jedlińska. (1989) The effect of combined exposures to ethanol and xylene on rat hepatic microsomal monooxygenase activities. Alcohol 6:5, pages 347-352.
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Lisbet Milling Pedersen. (1987) Biological Studies in Human Exposure to and Poisoning with Organic Solvents: Kinetics, Haemotology, and Serum Chemistry. Pharmacology & Toxicology 61, pages 1-55.
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Stanley R. Howell, John E. Christian & Gary E. Isom. (1986) The hepatotoxic potential of combined toluene-chronic ethanol exposure. Archives of Toxicology 59:1, pages 45-50.
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Asoka Pathiratne, Robert L. Puyear & James D. Brammer. (1986) A comparative study of the effects of benzene, toluene, and xylenes on their in vitro metabolism and drug-metabolizing enzymes in rat liver. Toxicology and Applied Pharmacology 82:2, pages 272-280.
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Gordon T. Pryor, Robert A. Howd, Edward T. Uyeno & Andrea B. Thurber. (1985) Interactions between toluene and alcohol. Pharmacology Biochemistry and Behavior 23:3, pages 401-410.
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Eivor Elovaara, Kerstin Engström & Harri Vainio. (1984) Metabolism and disposition of simultaneously inhaled m-xylene and ethylbenzene in the rat. Toxicology and Applied Pharmacology 75:3, pages 466-478.
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H. A. Waldron, Nicola Cherry & J. D. Johnston. (1983) The effects of ethanol on blood toluene concentrations. International Archives of Occupational and Environmental Health 51:4, pages 365-369.
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Rune Toftgård. (1983) Effects of xylene exposure on the metabolism of antipyrine in vitro and in vivo in the rat. Toxicology 28:1-2, pages 117-131.
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Rune Toftgård, Odd G. Nilsen, Hans Glaumann & Jan-Åke Gustafsson. (1983) Induction of cytochrome P-450 in the rat liver after exposure to xylenes, dose-response relationship and dependence on endocrine factors. Toxicology 27:2, pages 119-137.
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H K Wilson, S M Robertson, H A Waldron & D Gompertz. (1983) Effect of alcohol on the kinetics of mandelic acid excretion in volunteers exposed to styrene vapour.. Occupational and Environmental Medicine 40:1, pages 75-80.
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Rune Toftgård, Odd G. Nilsen & Jan‐Åke Gustafsson. (2009) Dose Dependent Induction of Rat Liver Microsomal Cytochrome P‐450 and Microsomal Enzymatic Activities after Inhalation of Toluene and Dichloromethane. Acta Pharmacologica et Toxicologica 51:2, pages 108-114.
Crossref
E. Elovaara, P. Pfäffli, H. Savolainen & H. Vainio. (2006) Marginal role of impaired aldehyde metabolism in m ‐xylene vapour‐induced biochemical effects in the rat . Journal of Applied Toxicology 2:1, pages 27-32.
Crossref
Rune Toftgård & Odd G. Nilsen. (1982) Effects of xylene and xylene isomers on cytochrome P-450 and in vitro enzymatic activities in rat liver, kidney and lung. Toxicology 23:2-3, pages 197-212.
Crossref

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