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Xenobiotica
the fate of foreign compounds in biological systems
Volume 10, 1980 - Issue 7-8
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Research Article

Metabolism of o-[methyl-14C]toluidine in the F344 rat

Ock Soon Son Division of Molecular Biology, Naylor Dana Institute for Disease Prevention, American Health Foundation, Dana Road, Valhalla, New York, 10595
,
D. W. Everett Division of Molecular Biology, Naylor Dana Institute for Disease Prevention, American Health Foundation, Dana Road, Valhalla, New York, 10595
&
E. S. Fiala Division of Molecular Biology, Naylor Dana Institute for Disease Prevention, American Health Foundation, Dana Road, Valhalla, New York, 10595
Pages 457-468 | Received 30 Oct 1979, Published online: 22 Sep 2008

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KennethK. Brown, AlexanderW. Teass, Steve Simon & ElizabethM. Ward. (1995) A Biological Monitoring Method for o-Toluidine and Aniline in Urine Using High Performance Liquid Chromatography with Electrochemical Detection. Applied Occupational and Environmental Hygiene 10:6, pages 557-565.
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S. Boeren, B. Tyrakowska, J. Vervoort, E. de Hoffman, K. Teunis, A. Van Veldhuizen & I. M. C. M. Rietjens. (1992) Rat liver microsomal metabolism of 2-halogenated 4-methylanilines. Xenobiotica 22:12, pages 1403-1423.
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Saori Takagi, Shinnosuke Ando, Ryoko Kono, Yuka Oono, Hiroshi Nagasaka & Hikaru Kohase. (2022) Methemoglobinemia Induced by Prilocaine in a Child With Noonan Syndrome. Anesthesia Progress 69:3, pages 25-29.
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Terry W. Schultz, Atanas Chapkanov, Stela Kutsarova & Ovanes G. Mekenyan. (2022) Assessment of uncertainty and credibility of predictions by the OECD QSAR Toolbox automated read-across workflow for predicting acute oral toxicity. Computational Toxicology 22, pages 100219.
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Emmanuel Guntz, Andrea Carini, Stephan Koslitz, Thomas Brüning, Panayota Kapessidou & Tobias Weiss. (2021) Quantification of systemic o-toluidine after intrathecal administration of hyperbaric prilocaine in humans: a prospective cohort study. Archives of Toxicology 95:3, pages 925-934.
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Megumi SUDA, Yukie YANAGIBA, Tatsushi TOYOOKA, Rui-Sheng WANG & Shigeki KODA. (2021) The Quantitative Analysis Method of Urinary Aromatic Amines and Their Metabolites using Liquid Chromatography -Tandem Mass Spectrometry with Correction for Matrix Effectsマトリックス効果を補正する液体クロマトグラフィ̶タンデム型質量分析装置を用いたヒト尿中芳香族アミン類の定量方法. Journal of Occupational Safety and Health 14:1, pages 3-14.
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Nao Yukimatsu, Min Gi, Takahiro Okuno, Masaki Fujioka, Shugo Suzuki, Anna Kakehashi, Yukie Yanagiba, Megumi Suda, Shigeki Koda, Tatsuya Nakatani & Hideki Wanibuchi. (2019) Promotion effects of acetoaceto-o-toluidide on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced bladder carcinogenesis in rats. Archives of Toxicology 93:12, pages 3617-3631.
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Yoko Eitaki, Makiko Nakano, Toshio Kawai, Kazuyuki Omae & Toru Takebayashi. (2019) Biological monitoring of o ‐toluidine in urine pretreated by an enzymatic deconjugation method . Journal of Occupational Health 61:5, pages 349-357.
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Takahiro Okuno, Min Gi, Masaki Fujioka, Nao Yukimatu, Anna Kakehashi, Akito Takeuchi, Ginji Endo, Yoko Endo & Hideki Wanibuchi. (2019) Acetoaceto-o-Toluidide Enhances Cellular Proliferative Activity in the Urinary Bladder of Rats. Toxicological Sciences 169:2, pages 456-464.
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Gabriele Sabbioni. (2017) Hemoglobin Adducts and Urinary Metabolites of Arylamines and Nitroarenes. Chemical Research in Toxicology 30:10, pages 1733-1766.
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June K. Dunnick, Keith R. Shockley, Daniel L. Morgan, Amy Brix, Gregory S. Travlos, Kevin Gerrish, J. Michael Sanders, T. V. Ton & Arun R. Pandiri. (2016) Hepatic transcriptomic alterations for N,N-dimethyl-p-toluidine (DMPT) and p-toluidine after 5-day exposure in rats. Archives of Toxicology 91:4, pages 1685-1696.
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Wenjie Ye, Uthpala I. Seneviratne, Ming-Wei Chao, Kodihalli C. Ravindra, Gerald N. Wogan, Steven R. Tannenbaum & Paul L. Skipper. (2012) Transimination of Quinone Imines: A Mechanism for Embedding Exogenous Redox Activity into the Nucleosome. Chemical Research in Toxicology 25:12, pages 2627-2629.
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Ming-Wei Chao, Min Young Kim, Wenjie Ye, Jing Ge, Laura J. Trudel, Crystal L. Belanger, Paul L. Skipper, Bevin P. Engelward, Steven R. Tannenbaum & Gerald N. Wogan. (2012) Genotoxicity of 2,6- and 3,5-Dimethylaniline in Cultured Mammalian Cells: The Role of Reactive Oxygen Species. Toxicological Sciences 130:1, pages 48-59.
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J. Caroline English, Virunya S. Bhat, Gwendolyn L. Ball & Clifton J. McLellan. (2012) Establishing a total allowable concentration of o-toluidine in drinking water incorporating early lifestage exposure and susceptibility. Regulatory Toxicology and Pharmacology 64:2, pages 269-284.
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Jadwiga Jodynis-Liebert & Hassen A. H. Bennasir. (2016) Effect of Dietary Fat on Selected Parameters of Toxicity Following 1- or 3-Month Exposure of Rats to Toluidine Isomers. International Journal of Toxicology 24:5, pages 365-376.
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. (2016) Final Report on the Safety Assessment of 6-Amino-m-Cresol, 6-Amino-o-Cresol, 4-Amino-m-Cresol, 5-Amino-4-Chloro-o-Cresol, 5-Amino-6-Chloro-o-Cresol, and 4-Chloro-2-Aminophenol1. International Journal of Toxicology 23:2_suppl, pages 1-22.
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Giovanni Brambilla & Antonietta Martelli. (2004) Failure of the standard battery of short-term tests in detecting some rodent and human genotoxic carcinogens. Toxicology 196:1-2, pages 1-19.
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Hanna Szaefer, Jadwiga Jodynis-Liebert, Michał Cichocki, Arleta Matuszewska & Wanda Baer-Dubowska. (2003) Effect of naturally occurring plant phenolics on the induction of drug metabolizing enzymes by o-toluidine. Toxicology 186:1-2, pages 67-77.
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June K. Dunnick, Leo T. Burka, Joel Mahler & Robert Sills. (2003) Carcinogenic potential of o-nitrotoluene and p-nitrotoluene. Toxicology 183:1-3, pages 221-234.
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J Jodynis-LiebertM Murias. (2016) Modulation of antioxidant defence system by dietary fat in rats intoxicated with o-toluidine. Human & Experimental Toxicology 21:12, pages 659-665.
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Yasuhiro Ohkuma, Yusuke Hiraku, Shinji Oikawa, Naruto Yamashita, Mariko Murata & Shosuke Kawanishi. (1999) Distinct Mechanisms of Oxidative DNA Damage by Two Metabolites of Carcinogenic o-Toluidine. Archives of Biochemistry and Biophysics 372:1, pages 97-106.
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Janneke Koerts, Sjef Boeren, Jacques Vervoort, Raymond Weiss, Cees Veeger & Ivonne M.C.M. Rietjens. (1996) Interaction between the substrate and the high-valent-iron-oxo porphyrin cofactor as a possible factor influencing the regioselectivity of cytochrome P450 catalysed aromatic ring hydroxylation of 3-fluoro(methyl)anilines. Chemico-Biological Interactions 99:1-3, pages 129-146.
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Janneke Koerts, Ivonne M.C.M. Rietjens, Marelle G. Boersma & Jacques Vervoort. (1995) 1 H NMR T 1 relaxation rate study on substrate orientation of fluoromethylanilines in the active sites of microsomal and purified cytochromes P 450 1A1 and 2B1 . FEBS Letters 368:2, pages 279-284.
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Jerzy Gnojkowski, Wanda Baer-Dubowska, Dorota Klimek & Józef Chmiel. (1984) Effect of toluidines on drug metabolizing enzymes in rat liver, kidney and lung. Toxicology 32:4, pages 335-342.
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M Nussbaum, E S Fiala, B Kulkarni, K El-Bayoumy & J H Weisburger. (1983) In vivo metabolism of 3,2'-dimethyl-4-aminobiphenyl (DMAB) bearing on its organotropism in the Syrian golden hamster and the F344 rat.. Environmental Health Perspectives 49, pages 223-231.
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