Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 10, 1980 - Issue 7-8
Submit an article Journal homepage
6
Views
13
CrossRef citations to date
0
Altmetric
Research Article

Evidence for p-hydroxylation of N-ethyl-N-methylaniline

J. W. Gorrod Department of Pharmacy, Chelsea College (University of London), Manresa Road, London, SW3 6LX, UK
&
L. H. Patterson Department of Pharmacy, Chelsea College (University of London), Manresa Road, London, SW3 6LX, UK; The School of Pharmacy, The Leicester Polytechnic, Leicester, LE1 9BH, UK
Pages 603-610 | Received 10 Feb 1980, Published online: 22 Sep 2008

Citations (13)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

M. Ulgen, J. W. Gorrod & D. Barlow. (1994) Structure-activity relationships in the formation of amides from substituted N-benzylanilines. Xenobiotica 24:8, pages 735-748.
Read now
J. W. Gorrod & D. Manson. (1986) The metabolism of aromatic amines. Xenobiotica 16:10-11, pages 933-955.
Read now
J. W. Gorrod & N. J. Gooderham. (1985) Microsomal N- and C-oxidation of 4-substituted N-benzylanilines. Xenobiotica 15:12, pages 1021-1031.
Read now
A. H. Beckett, A. J. Hutt & G. E. Navas. (1983) Metabolism of imipramine in vitro: synthesis and characterization of N-hydroxydesmethylimipramine. Xenobiotica 13:7, pages 391-405.
Read now

Articles from other publishers (9)

P. N. D'Yachkov, N. V. Kharchevnikova, A. V. Dmitriev, A. V. Kuznetsov & V. V. Poroikov. (2007) Quantum chemical simulation of cytochrome P450 catalyzed aromatic oxidation: Metabolism, toxicity, and biodegradation of benzene derivatives. International Journal of Quantum Chemistry 107:13, pages 2454-2478.
Crossref
Marcus Taupp, Frank Heckel, Dag Harmsen & Peter Schreier. (2006) Biohydroxylation of N,N-dialkylarylamines by the isolated topsoil bacterium Bacillus megaterium. Enzyme and Microbial Technology 38:7, pages 1013-1016.
Crossref
Ilkay Küçükgüzel, Mert Ülgen & John W Gorrod. (1999) In vitro hepatic microsomal metabolism of N-benzyl-N-methylaniline. Il Farmaco 54:5, pages 331-337.
Crossref
M. R. Hadley, H. G. Oldham, L. A. Damani & A. J. Hutt. (1998) High performance liquid chromatographic analysis of theIn vitro N-dealkylated andN-oxide metabolites ofN-ethyl-N-methylaniline: Methodology for the determination of enzyme activity and stereoselectivity ofN-oxidation. Chromatographia 48:9-10, pages 664-670.
Crossref
Mert Ulgen, Ufuk Ozer, Ilkay Kucukguzel & John W. Gorrod. (1997) MICROSOMAL METABOLISM OF N-BENZYL-N-ETHYLANILINE AND N-BENZYL-N-ETHYL-p-TOLUIDINE. Drug Metabolism and Drug Interactions 14:2.
Crossref
Mark R. Hadley, Harriet G. Oldham, Patrick Camilleri, Lyaquatali A. Damani & Andrew J. Hutt. (1996) Species differences in the stereoselectivity ofN-oxygenation ofN-ethyl-N-methylaniline in vitro. Chirality 8:6, pages 430-440.
Crossref
N.J. Gooderham & J.W. Gorrod. (1984) The application of reversed-phase high-performance liquid chromatography to in vitro drug metabolism studies with n-alkylarylamines. Journal of Chromatography B: Biomedical Sciences and Applications 309, pages 339-346.
Crossref
David A. Cowan, Laurence H. Patterson, Lyaquatali A. Damani & John W. Gorrod. (1982) Metabolism of 4-substituted-N-ethyl-N-methylanilines: Chromatographic and mass spectrometric identification ofN-oxidation metabolic products formedin vitro. Biological Mass Spectrometry 9:6, pages 233-240.
Crossref
J. W. Gorrod & N. J. Gooderham. (1981) The in vitro metabolism of N,N-dimethylaniline by guinea pig and rabbit tissue preparations. European Journal of Drug Metabolism and Pharmacokinetics 6:3, pages 195-206.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.