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Xenobiotica
the fate of foreign compounds in biological systems
Volume 10, 1980 - Issue 7-8
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Research Article

Reversed phase high-performance liquid chromatography of heterocyclic aromatic N-oxides: application to measurement of N-oxidation by microsomes and rat hepatocytes in primary culture

B. J. Blaauboer M.R.C. Toxicology Unit, Medical Research Council Laboratories, Woodmansterne Road, Carshalton, Surrey, UK; Institute of Veterinary Pharmacology and Toxicology, State University, Biltstraat 172, Utrecht, The Netherlands
&
A. J. Paine M.R.C. Toxicology Unit, Medical Research Council Laboratories, Woodmansterne Road, Carshalton, Surrey, UK
Pages 655-660 | Received 19 Jan 1980, Published online: 22 Sep 2008

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Raymond f. Novak, Karen l. Kaul & Sang Geon Kim. (1989) Induction of the Alcohol Inducible Form of Cytochrome P-450 By Nitrogen-Containing Heterocycles: Effects on Pyridine It-Oxide Production. Drug Metabolism Reviews 20:2-4, pages 781-792.
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T. J. Wilke, W. R. Jondorf & G. Powis. (1989) Oxidative metabolism of 14C-pyridine by human and rat tissue subcellular fractions. Xenobiotica 19:9, pages 1013-1022.
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C. T. A. Evelo, J. F. M. Versteegh & B. J. Blaauboer. (1984) Kinetics of the formation and secretion of the aniline metabolite 4-aminophenol and its conjugates by isolated rat hepatocytes. Xenobiotica 14:5, pages 409-416.
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B. J. Blaauboer & C. W. M. Van Holsteijn. (1983) Formation and disposition of N-hydroxylated metabolites of aniline and nitrobenzene by isolated rat hepatocytes. Xenobiotica 13:5, pages 295-302.
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Peter Hlavica & John W. Gorrod. (1982) Biological Oxidation of Nitrogen in Organic Compounds and Disposition of N-Oxidized Product. Critical Reviews in Biochemistry 12:1, pages 39-101.
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Articles from other publishers (8)

Zvi RappoportPeter Hlavica & Michael Lehnerer. 2010. Patai's Chemistry of Functional Groups. Patai's Chemistry of Functional Groups.
T. Gul Altuntas & John W. Gorrod. (1995) Factors Involved in the N-Oxidation of Isomeric Aromatic Diazines by Microsomal Preparations. Drug Metabolism and Drug Interactions 12:2.
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Sang Geon Kim & Raymond F. Novak. 1991. Biological Reactive Intermediates IV. Biological Reactive Intermediates IV 753 758 .
Alan J. Paine. (1990) The maintenance of cytochrome P-450 in rat hepatocyte culture: Some applications of liver cell cultures to the study of drug metabolism, toxicity and the induction of the P-450 system. Chemico-Biological Interactions 74:1-2, pages 1-31.
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John A. Thompson, Kenneth J. Norris & Dennis R. Petersen. (1985) Isolation and analysis of N-oxide metabolites of tertiary amines: Quantitation of nicotine-1′-N-oxide formation in mice. Journal of Chromatography B: Biomedical Sciences and Applications 341, pages 349-359.
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Kenji Nomura, Mariko Shin, Keiji Sano, Chisae Umezawa & Tsutomu Shimada. (1983) Nicotinamide N-oxide formation by rat liver microsomes. Biochemical Pharmacology 32:5, pages 934-936.
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M.S Shaker, P.A Crooks & L.A Damani. (1982) High-performance liquid chromatographic analysis of the in vivo metabolites of [14C]pyridine. Journal of Chromatography A 237:3, pages 489-495.
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Gösta Hallström & Björn Lindeke. (1981) MetabolicN-oxidation of α-acetylenic amines—A gas chromatographic mass spectrometric investigation of the chemical decomposition ofN-(5-pyrrolidinopent-3-ynyl)succinimideN'-oxide using deuterium substitution. Biological Mass Spectrometry 8:10, pages 514-520.
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