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S. Peter Hong, Alfred F. Fuciarelli, Jerry D. Johnson, Steven W. Graves, Derrick J. Bates, Cynthia S. Smith & Suramya Waidyanatha. (2013) Toxicokinetics of Isoeugenol in F344 rats and B6C3F1 mice. Xenobiotica 43:11, pages 1010-1017.
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I. U. Fischer, G. E. Von Unruh & H. J. Dengler. (1990) The metabolism of eugenol in man. Xenobiotica 20:2, pages 209-222.
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Marcel Delaforge, Costas Ioannides & Dennis V. Parke. (1985) Ligand-complex formation between cytochromes P-450 and P-448 and methylenedioxyphenyl compounds. Xenobiotica 15:4, pages 333-342.
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Articles from other publishers (35)
A.M. Api, D. Belsito, D. Botelho, M. Bruze, G.A. BurtonJr.Jr., M.A. Cancellieri, H. Chon, M.L. Dagli, W. Dekant, C. Deodhar, A.D. Fryer, L. Jones, K. Joshi, M. Kumar, A. Lapczynski, M. Lavelle, I. Lee, D.C. Liebler, H. Moustakas, M. Na, T.M. Penning, G. Ritacco, J. Romine, N. Sadekar, T.W. Schultz, D. Selechnik, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar & Y. Tokura. (2024) RIFM fragrance ingredient safety assessment, eugenyl methyl ether, CAS Registry Number 93-15-2. Food and Chemical Toxicology 183, pages 114209.
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A.M. Api, D. Belsito, D. Botelho, M. Bruze, G.A. BurtonJr.Jr., M.A. Cancellieri, H. Chon, M.L. Dagli, W. Dekant, C. Deodhar, A.D. Fryer, L. Jones, K. Joshi, M. Kumar, A. Lapczynski, M. Lavelle, I. Lee, D.C. Liebler, H. Moustakas, J. Muldoon, M. Na, T.M. Penning, G. Ritacco, J. Romine, N. Sadekar, T.W. Schultz, D. Selechnik, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar & Y. Tokura. (2023) RIFM fragrance ingredient safety assessment, estragole, CAS registry number 140-67-0. Food and Chemical Toxicology 182, pages 114143.
Crossref
Crossref
Xiaoling Zhang, Susan P. Felter, Anne Marie Api, Kaushal Joshi & Dan Selechnik. (2022) A Cautionary tale for using read-across for cancer hazard classification: Case study of isoeugenol and methyl eugenol. Regulatory Toxicology and Pharmacology 136, pages 105280.
Crossref
Crossref
Mario E. Götz, Benjamin Sachse, Bernd Schäfer & Andreas Eisenreich. (2022) Myristicin and Elemicin: Potentially Toxic Alkenylbenzenes in Food. Foods 11:13, pages 1988.
Crossref
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Thais Pereira Lopes, Cristina Rodrigues dos Santos Barbosa, Nair Silva Macêdo, Jackelyne Roberta Scherf, Maria Apoliana Costa dos Santos, Thiago Sampaio de Freitas, Jaime Ribeiro Filho, Henrique Douglas Melo Coutinho, Abolghasem Siyadatpanah, Polrat Wilairatana, Francisco Assis Bezerra da Cunha & Alysson Pontes Pinheiro. (2022) Pharmacological activities of allylbenzene and allylanisole phenylpropanoids: Inhibition of antibiotic resistance targets and toxicity profile in a Drosophila melanogaster model. Journal of King Saud University - Science 34:4, pages 101995.
Crossref
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A.M. Api, D. Belsito, D. Botelho, M. Bruze, G.A. BurtonJr.Jr., J. Buschmann, M.A. Cancellieri, M.L. Dagli, M. Date, W. Dekant, C. Deodhar, A.D. Fryer, L. Jones, K. Joshi, M. Kumar, A. Lapczynski, M. Lavelle, I. Lee, D.C. Liebler, H. Moustakas, M. Na, T.M. Penning, G. Ritacco, J. Romine, N. Sadekar, T.W. Schultz, D. Selechnik, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar & Y. Tokura. (2022) Update to RIFM fragrance ingredient safety assessment, eugenol, CAS Registry Number 97-53-0. Food and Chemical Toxicology 163, pages 113027.
Crossref
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A.M. Api, D. Belsito, S. Biserta, D. Botelho, M. Bruze, G.A. BurtonJr.Jr., J. Buschmann, M.A. Cancellieri, M.L. Dagli, M. Date, W. Dekant, C. Deodhar, A.D. Fryer, S. Gadhia, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, D.C. Liebler, M. Na, D. O'Brien, A. Patel, T.M. Penning, G. Ritacco, F. Rodriguez-Ropero, J. Romine, N. Sadekar, D. Salvito, T.W. Schultz, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura & S. Tsang. (2021) RIFM fragrance ingredient safety assessment, 2-methoxy-4-propylphenol, CAS Registry Number 2785-87-7. Food and Chemical Toxicology 149, pages 111853.
Crossref
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Phirose Kemprai, Bhaskar Protim Mahanta, Dristi Sut, Rubi Barman, Dipanwita Banik, Mohan Lal, Siddhartha Proteem Saikia & Saikat Haldar. (2019) Review on safrole: identity shift of the ‘candy shop’ aroma to a carcinogen and deforester. Flavour and Fragrance Journal 35:1, pages 5-23.
Crossref
Crossref
A.M. Api, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M.L. Dagli, W. Dekant, A.D. Fryer, L. Kromidas, S. La Cava, J.F. Lalko, A. Lapczynski, D.C. Liebler, Y. Miyachi, V.T. Politano, G. Ritacco, D. Salvito, T.W. Schultz, J. Shen, I.G. Sipes, B. Wall & D.K. Wilcox. (2016) RIFM fragrance ingredient safety assessment, Eugenol, CAS Registry Number 97-53-0. Food and Chemical Toxicology 97, pages S25-S37.
Crossref
Crossref
Huina Yao, Ying Peng & Jiang Zheng. (2016) Identification of glutathione and related cysteine conjugates derived from reactive metabolites of methyleugenol in rats. Chemico-Biological Interactions 253, pages 143-152.
Crossref
Crossref
. 2014. Essential Oil Safety. Essential Oil Safety
677
755
.
Robert Tisserand & Rodney Young. 2014. Essential Oil Safety. Essential Oil Safety
483
647
.
Alexander T. Cartus, Kristin Herrmann, Lucas W. Weishaupt, Karl-Heinz Merz, Wolfram Engst, Hansruedi Glatt & Dieter Schrenk. (2012) Metabolism of Methyleugenol in Liver Microsomes and Primary Hepatocytes: Pattern of Metabolites, Cytotoxicity, and DNA-Adduct Formation. Toxicological Sciences 129:1, pages 21-34.
Crossref
Crossref
Erryana Martati, Marelle G. Boersma, Albertus Spenkelink, Dambar B. Khadka, Peter J. van Bladeren, Ivonne M. C. M. Rietjens & Ans Punt. (2012) Physiologically Based Biokinetic (PBBK) Modeling of Safrole Bioactivation and Detoxification in Humans as Compared With Rats. Toxicological Sciences 128:2, pages 301-316.
Crossref
Crossref
Su-yin Chiang, Pei-yi Lee, Ming-tsung Lai, Li-ching Shen, Wen-sheng Chung, Hui-fen Huang, Kuen-yuh Wu & Hsiu-ching Wu. (2011) Safrole-2′,3′-oxide induces cytotoxic and genotoxic effects in HepG2 cells and in mice. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 726:2, pages 234-241.
Crossref
Crossref
E. Martati, M. G. Boersma, A. Spenkelink, D. B. Khadka, A. Punt, J. Vervoort, P. J. van Bladeren & I. M. C. M. Rietjens. (2011) Physiologically Based Biokinetic (PBBK) Model for Safrole Bioactivation and Detoxification in Rats. Chemical Research in Toxicology 24:6, pages 818-834.
Crossref
Crossref
Donald G. Barceloux. 2008. Medical Toxicology of Natural Substances. Medical Toxicology of Natural Substances
437
442
.
Suzanne M.F. Jeurissen, Ans Punt, Thierry Delatour & Ivonne M.C.M. Rietjens. (2008) Basil extract inhibits the sulfotransferase mediated formation of DNA adducts of the procarcinogen 1′-hydroxyestragole by rat and human liver S9 homogenates and in HepG2 human hepatoma cells. Food and Chemical Toxicology 46:6, pages 2296-2302.
Crossref
Crossref
Ivonne M.C.M. Rietjens, Marelle G. Boersma, Hester van der Woude, Suzanne M.F. Jeurissen, Maaike E. Schutte & Gerrit M. Alink. (2005) Flavonoids and alkenylbenzenes: Mechanisms of mutagenic action and carcinogenic risk. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 574:1-2, pages 124-138.
Crossref
Crossref
R.L Smith, T.B Adams, J Doull, V.J Feron, J.I Goodman, L.J Marnett, P.S Portoghese, W.J Waddell, B.M Wagner, A.E Rogers, J Caldwell & I.G Sipes. (2002) Safety assessment of allylalkoxybenzene derivatives used as flavouring substances — methyl eugenol and estragole. Food and Chemical Toxicology 40:7, pages 851-870.
Crossref
Crossref
Thomas M Guenthner & Gang Luo. (2001) Investigation of the role of the 2′,3′-epoxidation pathway in the bioactivation and genotoxicity of dietary allylbenzene analogs. Toxicology 160:1-3, pages 47-58.
Crossref
Crossref
Jerry D. Johnson, Michael J. Ryan, John D. Toft, Steven W. Graves, Milton R. Hejtmancik, Michael L. Cunningham, Ron Herbert & Kamal M. Abdo. (2000)
Two-Year Toxicity and Carcinogenicity Study of Methyleugenol in F344/N Rats and B6C3F
1
Mice
. Journal of Agricultural and Food Chemistry 48:8, pages 3620-3632.
Crossref
Crossref
M. De Vincenzi, M. Silano, P. Stacchini & B. Scazzocchio. (2000) Constituents of aromatic plants: I. Methyleugenol. Fitoterapia 71:2, pages 216-221.
Crossref
Crossref
G. Abel. 1997. Adverse Effects of Herbal Drugs. Adverse Effects of Herbal Drugs
105
122
.
Richard J. Brennan, Sridevi Kandikonda, Achot P. Khrimian, Albert B. DeMilo, Nicanor J. Liquido & Robert H. Schiestl. (1996) Saturated and monofluoro analogs of the oriental fruit fly attractant methyl eugenol show reduced genotoxic activities in yeast. Mutation Research/Genetic Toxicology 369:3-4, pages 175-181.
Crossref
Crossref
Mazen K. Qato & Thomas M. Guenthner. (1995) 32P-postlabeling analysis of adducts formed between DNA and safrole 2′,3′-epoxide: absence of adduct formation in vivo. Toxicology Letters 75:1-3, pages 201-207.
Crossref
Crossref
Lutz Müller, P. Kasper, K. Müller-Tegethoff & T. Petr. (1994) The genotoxic potential in vitro and in vivo of the allyl benzene etheric oils estragole, basil oil and. Mutation Research Letters 325:4, pages 129-136.
Crossref
Crossref
David C. Thompson, Despina Constantin-Teodosiu & Peter Moldéus. (1991) Metabolism and cytotoxicity of eugenol in isolated rat hepatocytes. Chemico-Biological Interactions 77:2, pages 137-147.
Crossref
Crossref
David Thompson, Despina Constantin-Teodosiu, B?rje Egestad, Henrik Mickos & Peter Mold?us. (1990) Formation of glutathione conjugates during oxidation of eugenol by microsomal fractions of rat liver and lung. Biochemical Pharmacology 39:10, pages 1587-1595.
Crossref
Crossref
I.U. Fischer & H.J. Dengler. (1990) Sensitive high-performance liquid chromatographic assay for the determination of eugenol in body fluids. Journal of Chromatography B: Biomedical Sciences and Applications 525, pages 369-377.
Crossref
Crossref
YIN-TAK WOO, DAVID Y. LAI, JOSEPH C. ARCOS & MARY F. ARGUS. 1988. Natural, Metal, Fiber, and Macromolecular Carcinogens. Natural, Metal, Fiber, and Macromolecular Carcinogens
3
616
.
A. Anthony, J. Caldwell, A.J. Hutt & R.L. Smith. (1987) Metabolism of estragole in rat and mouse and influence of dose size on excretion of the proximate carcinogen 1′-hydroxyestragole. Food and Chemical Toxicology 25:11, pages 799-806.
Crossref
Crossref
Costas Ioannides, Marcel Delaforge & Dennis V. Parke. (1985) Interactions of safrole and isosafrole and their metabolites with cytochromes P-450. Chemico-Biological Interactions 53, pages 303-311.
Crossref
Crossref
Andrew Zangouras, John Caldwell, Andrew J. Hutt & Robert L. Smith. (1981) Dose dependent conversion of estragole in the rat and mouse to the carcinogenic metabolite, 1 -hydroxyestragole. Biochemical Pharmacology 30:11, pages 1383-1386.
Crossref
Crossref
C. Ioannides, M. Delaforge & D.V. Parke. (1981) Safrole: Its metabolism, carcinogenicity and interactions with cytochrome P-450. Food and Cosmetics Toxicology 19, pages 657-666.
Crossref
Crossref