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Xenobiotica
the fate of foreign compounds in biological systems
Volume 10, 1980 - Issue 11
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Research Article

A study of the debrisoquine hydroxylation polymorphism in a Nigerian population

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Pages 811-818 | Received 15 Mar 1980, Published online: 22 Sep 2008

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Marco Alessandrini, Sahle Asfaha, Tyren Mark Dodgen, Louise Warnich & Michael Sean Pepper. (2013) Cytochrome P450 pharmacogenetics in African populations. Drug Metabolism Reviews 45:2, pages 253-275.
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Yukio Horai, Takashi Ishizaki, Michel Eichelbaum, Keitaro Hashimoto, Kan Chiba & Hans J. Dengler. (1988) Further Analysis of Sparteine Oxidation in a Japanese Population and Comparison with Data Observed in Different Ethnic Populations. Xenobiotica 18:9, pages 1077-1084.
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S. I. Islam, J. R. Idle & R. L. Smith. (1980) The polymorphic 4-hydroxylation of debrisoquine in a Saudi arab population. Xenobiotica 10:11, pages 819-825.
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Articles from other publishers (39)

Iris Rajman, Laura Knapp, Thomas Morgan & Collen Masimirembwa. (2017) African Genetic Diversity: Implications for Cytochrome P450-mediated Drug Metabolism and Drug Development. EBioMedicine 17, pages 67-74.
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Howard S. Smith. (2009) Opioid Metabolism. Mayo Clinic Proceedings 84:7, pages 613-624.
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Adrián LLerenaPedro DoradoEva M Peñas-Lledó. (2009) Pharmacogenetics of debrisoquine and its use as a marker for CYP2D6 hydroxylation capacity. Pharmacogenomics 10:1, pages 17-28.
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Yueying Zhen, Ondřej Slanař, Kristopher W. Krausz, Chi Chen, Josef Slavík, Kerry L. McPhail, T. Mark Zabriskie, František Perlík, Frank J. Gonzalez & Jeffrey R. Idle. (2006) 3,4-Dehydrodebrisoquine, a Novel Debrisoquine Metabolite Formed from 4-Hydroxydebrisoquine That Affects the CYP2D6 Metabolic Ratio. Drug Metabolism and Disposition 34:9, pages 1563-1574.
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Stephen Bernard, Kathleen A. Neville, Anne T. Nguyen & David A. Flockhart. (2006) Interethnic Differences in Genetic Polymorphisms of CYP2D6 in the U.S. Population: Clinical Implications. The Oncologist 11:2, pages 126-135.
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Takako Shimizu, Hirohide Ochiai, Fredrik Åsell, Hiroshi Shimizu, Ryuta Saitoh, Yoshimasa Hama, Jun Katada, Munehiro Hashimoto, Hitoshi Matsui, Katsuhiko Taki, Tsuguchika Kaminuma, Michiko Yamamoto, Yoshitaka Aida, Akira Ohashi & Naoki Ozawa. (2003) Bioinformatics Research on Inter-racial Difference in Drug Metabolism I. Analysis on Frequencies of Mutant Alleles and Poor Metabolizers on CYP2D6 and CYP2C19. Drug Metabolism and Pharmacokinetics 18:1, pages 48-70.
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Camille P. Granvil, Kristopher W. Krausz, Harry V. Gelboin, Jeffrey R. Idle & Frank J. Gonzalez. (2002) 4-Hydroxylation of Debrisoquine by Human CYP1A1 and Its Inhibition by Quinidine and Quinine. Journal of Pharmacology and Experimental Therapeutics 301:3, pages 1025-1032.
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Poolsup, Li Wan Po & Knight. (2000) Pharmacogenetics and psychopharmacotherapy. Journal of Clinical Pharmacy and Therapeutics 25:3, pages 197-220.
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Lise Bathum, Erik Skjelbo, Theonest K. Mutabingwa, Hanne Madsen, Mogens Hørder & Kim Brøsen. (2001) Phenotypes and genotypes for CYP2D6 and CYP2C19 in a black Tanzanian population. British Journal of Clinical Pharmacology 48:3, pages 395-401.
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Edyta J Frackiewicz, John J Sramek, John M Herrera, Neil M Kurtz & Neal R Cutler. (2016) Ethnicity and Antipsychotic Response. Annals of Pharmacotherapy 31:11, pages 1360-1369.
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Collen M. Masimirembwa & Julia A. Hasler. (1997) Genetic Polymorphism of Drug Metabolising Enzymes in African Populations: Implications for the Use of Neuroleptics and Antidepressants. Brain Research Bulletin 44:5, pages 561-571.
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Robert J. Straka, Shawn R. Hansen & Patricia F. Walker. (1995) Comparison of the prevalence of the poor metabolizer phenotype for CYP2D6 between 203 Hmong subjects and 280 white subjects residing in Minnesota*. Clinical Pharmacology & Therapeutics 58:1, pages 29-34.
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D. Gail May. (2013) Genetic Differences in Drug Disposition. The Journal of Clinical Pharmacology 34:9, pages 881-897.
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M. S. Lennard. (1990) Genetic Polymorphism of Sparteine/Debrisoquine Oxidation: A Reappraisal. Pharmacology & Toxicology 67:4, pages 273-283.
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G. Boriarti, E. Strocchi, A. Capucci, S. Boschi, B. Marchesini, E. Ambrosioni & B. Magnani. (2012) Relationships Between Debrisoquine Hydroxylation and Propafenone Pharmacokinetics. Drug Investigation 2:2, pages 114-119.
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M. Eichelbaum & A.S. Gross. (1990) The genetic polymorphism of debrisoquine/sparteine metabolism — Clinical aspects. Pharmacology & Therapeutics 46:3, pages 377-394.
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De K. Sommers, J. Moncrieff & J. Avenant. (2016) Non-correlation between Debrisoquine and Metoprolol Polymorphisms in the Venda. Human Toxicology 8:5, pages 365-368.
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De K. Sommers, J. Moncrieff & J. Avenant. (2016) Metoprolol α-Hydroxylation Polymorphism in the San Bushmen of Southern Africa. Human Toxicology 8:1, pages 39-43.
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M.S. Lennard. (1989) The polymorphic oxidation of beta-adrenoceptor antagonists. Pharmacology & Therapeutics 41:3, pages 461-477.
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De K. Sommers, J. Moncrieff & J. Avenant. (2016) Polymorphism of the 4-Hydroxylation of Debrisoquine in the San Bushmen of Southern Africa. Human Toxicology 7:3, pages 273-276.
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M Jurima, T Inaba, D Kadar & W Kalow. (2012) Genetic polymorphism of mephenytoin p(4′)‐hydroxylation: difference between Orientals and Caucasians.. British Journal of Clinical Pharmacology 19:4, pages 483-487.
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D. B. Jack. (1983) Statistical analysis of polymorphic drug metabolism data using the Rosin Rammler Sperling Weibull distribution. European Journal of Clinical Pharmacology 25:4, pages 443-448.
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Adrian Küpfer, Sabah G. Al-Dabbagh, James C. Ritchie, Jeffrey R. Idle & Robert L. Smith. (1982) Spectral binding studies of the polymorphically metabolized drugs debrisoquine, sparteine and phenformin by cytochrome P-450 of normal and hydroxylation deficient rat strains. Biochemical Pharmacology 31:20, pages 3193-3199.
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MS Lennard, JH Silas, S Freestone & J Trevethick. (2012) Defective metabolism of metoprolol in poor hydroxylators of debrisoquine.. British Journal of Clinical Pharmacology 14:2, pages 301-303.
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