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Xenobiotica
the fate of foreign compounds in biological systems
Volume 10, 1980 - Issue 12
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Research Article

Metabolic fate of nicardipine hydrochloride, a new vasodilator, by various species in vitro

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Pages 889-896 | Received 04 Feb 1980, Published online: 22 Sep 2008

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T. Teramura, T. Tokunaga, H. Matsumoto, T. Watanabe & S. Higuchi. (1996) Metabolism of barnidipine hydrochloride, a potent calcium antagonist, in rat and dog. Xenobiotica 26:2, pages 177-187.
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N. Ogawa, K. Mizuno, K. Fukushima, T. Suwa & T. Satoh. (1993) Metabolic fate of a new dihydropyridine calcium antagonist, CD-349, in rat and dog. Xenobiotica 23:7, pages 747-759.
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A. P. Beresford, P. V. Macrae & D. A. Stopher. (1988) Metabolism of amlodipine in the rat and the dog: A species difference. Xenobiotica 18:2, pages 169-182.
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G. C. Visor, B. Schuessler, J. Thompson & T. Ling. (1987) Nasal Absorption of the Calcium Antagonist Nicardipine in Rats and Rhesus Monkeys. Drug Development and Industrial Pharmacy 13:8, pages 1329-1343.
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S. Terashita, Y. Tokuma, T. Fujiwara, Y. Shiokawa, K. Okumura & H. Noguchi. (1987) Metabolism of nilvadipine, a new dihydropyridine calcium antagonist, in rats and dogs. Xenobiotica 17:12, pages 1415-1425.
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W. R. Rush, O. Alexander, D. J. Hall, L. Cairncross, R. J. Dow & D. J. G. Graham. (1986) The metabolism of nicardipine hydrochloride in healthy male volunteers. Xenobiotica 16:4, pages 341-349.
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I. Midgley, L. F. Chasseaud, I. W. Taylor, L. M. Walmsley, A. G. Fowkes, A. Darragh, R. F. Lambe & R. Bonn. (1985) Metabolism and pharmacokinetics of the dihydropyridine calcium antagonist, ryosidine, in man. Xenobiotica 15:11, pages 965-977.
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C. Bäärnhielm, I. Skånberg & K. O. Borg. (1984) Cytochrome P-450-dependent oxidation of felodipine—a 1,4-dihydropyridine—to the corresponding pyridine. Xenobiotica 14:9, pages 719-726.
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Articles from other publishers (28)

Motoki Urata, Yuki Narita, Masaki Fukunaga, Daisuke Kadowaki & Sumio Hirata. (2018) Simple Formula for Predicting Drug Removal Rates During Hemodialysis. Therapeutic Apheresis and Dialysis 22:5, pages 485-493.
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Liang Li. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 4 .
Junko Mizumura, Nobutoshi Watari & Shigesada Higuchi. (1998) Possibility of Partial Absorption of Nicardipine by Routes Other Than the Hepato-portal System After Oral Administration in Rats. Journal of Pharmacy and Pharmacology 50:7, pages 775-781.
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Nobuyuki Sugioka, Hikaru Koyama, Mariko Kawakubo, Toshio Ohta, Hideki Kishimoto, Satoru Mori & Kenji Nakajima. (1996) Age-dependent Alteration of the Serum-unbound Fraction of Nicardipine, a Calcium-channel Blocker, in Man. Journal of Pharmacy and Pharmacology 48:12, pages 1327-1331.
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Hong-Mook Son & Jun-Shik Choi. (2010) Effects of Baicalein on the Bioavailability of Nicardipine in Rats. Journal of Pharmaceutical Investigation 40:5, pages 291-296.
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Jun-Shik Choi, Sung-Il Ha & Dong-Hyun Choi. (2010) Effects of Atorvastatin on the Pharmacokinetics of Nicardipine after Oral and Intravenous Administration in Rats. Biomolecules and Therapeutics 18:2, pages 226-232.
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Yong-Ji Piao & Jun-Shik Choi. (2008) Effects of morin on the pharmacokinetics of nicardipine after oral and intravenous administration of nicardipine in rats. Journal of Pharmacy and Pharmacology 60:5, pages 625-629.
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Naoe Yamane, Tomonori Takami, Zenzaburo Tozuka, Yuichi Sugiyama, Akira Yamazaki & Yuji Kumagai. (2009) Microdose Clinical Trial: Quantitative Determination of Nicardipine and Prediction of Metabolites in Human Plasma. Drug Metabolism and Pharmacokinetics 24:4, pages 389-403.
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Shoji MIYAJIMA, Kiyomitsu NEMOTO, Masashi SEKIMOTO, Yusuke KINAE, Toshihiko KASAHARA, Shinji SOUMA & Masakuni DEGAWA. (2007) INDUCTION OF HEPATIC CYTOCHROME P450 ISOFORMS BY NICARDIPINE AT THERAPEUTIC DOSES IN SPONTANEOUSLY HYPERTENSIVE RATS. The Journal of Toxicological Sciences 32:1, pages 79-90.
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Huadong Tang & Michael Mayersohn. (2006) A global examination of allometric scaling for predicting human drug clearance and the prediction of large vertical allometry**This work was presented at the American Association of Pharmaceutical Scientists Annual meeting, Salt Lake City, USA, Oct. 26, 2003.. Journal of Pharmaceutical Sciences 95:8, pages 1783-1799.
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Katsunori Nakamura, Noritaka Ariyoshi, Takafumi Iwatsubo, Yasuhisa Fukunaga, Saburou Higuchi, Kunio Itoh, Noriaki Shimada, Kazuo Nagashima, Tsuyoshi Yokoi, Koujirou Yamamoto, Ryuya Horiuchi & Tetsuya Kamataki. (2005) Inhibitory Effects of Nicardipine to Cytochrome P450 (CYP) in Human Liver Microsomes. Biological & Pharmaceutical Bulletin 28:5, pages 882-885.
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YL Kwak, YJ Oh, SO Bang, JH Lee, SM Jeong & YW Hong. (2004) Comparison of the Effects of Nicardipine and Sodium Nitroprusside for Control of Increased Blood Pressure after Coronary Artery Bypass Graft Surgery. Journal of International Medical Research 32:4, pages 342-350.
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P. O. Greiner, S. Weber, J. Angignard & B. Berbey. (1990) Evaluation of first pass effect and biliary excretion of diperdipine in the dog. European Journal of Drug Metabolism and Pharmacokinetics 15:3, pages 185-190.
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Michael E. Goldberg, Joseph L. Seltzer, Rico Viray & Prasad Turlapaty. (2016) Nicardipine Hydrochloride: The First Dihydropyridine Intravenous Calcium-Channel Antagonist. Journal of Pharmacy Technology 6:3, pages 93-98.
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Bramah N. Singh & Martin A. Josephson. (1990) Clinical pharmacology, pharmacokinetics, and hemodynamic effects of nicardipine. American Heart Journal 119:2, pages 427-434.
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Prasad Turlapaty, Rico Vary & Joel A. Kaplang. (1989) Nicardipine, a new intravenous calcium antagonist: a review of its pharmacology, pharmacokinetics, and perioperative applications. Journal of Cardiothoracic Anesthesia 3:3, pages 344-355.
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M. Guerret, G. Cheymol, M. Hubert, C. Julien-Larose & D. Lavene. (1989) Simultaneous study of the pharmacokinetics of intravenous and oral nicardipine using a stable isotope. European Journal of Clinical Pharmacology 37:4, pages 381-385.
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John G. Wagner, Teck L. Ling, Edward J. Mroszczak, Donna Freedman, Ann Wu, Bee Huang, Ian J. Massey & Robert R. Roe. (1987) Single intravenous dose and steady-state oral dose pharmacokinetics of nicardipine in healthy subjects. Biopharmaceutics & Drug Disposition 8:2, pages 133-148.
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C. Bäärnhielm, H. Dahlbäck & I. Skånberg. (2009) In Vivo Pharmacokinetics of Felodipine Predicted from in Vitro Studies in Rat, Dog and Man . Acta Pharmacologica et Toxicologica 59:2, pages 113-122.
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J Grotta, J Spydell, C Pettigrew, P Ostrow & D Hunter. (1986) The effect of nicardipine on neuronal function following ischemia.. Stroke 17:2, pages 213-219.
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G.C. Visor, E. Bajka & E. Benjamin. (1986) Intranasal Delivery of Nicardipine in the Rat. Journal of Pharmaceutical Sciences 75:1, pages 44-46.
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John S. Gelman, Robert L. Feldman, Elizabeth Scott & Carl J. Pepine. (1985) Nicardipine for angina pectoris at rest and coronary arterial spasm. The American Journal of Cardiology 56:4, pages 232-236.
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Kurt-J. Hoffmann & Lars Weidolf. (1985) Identification of felodipine metabolites in rat urine. Biological Mass Spectrometry 12:8, pages 414-423.
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Sherrin H. Baky. (2007) Nicardipine Hydrochloride. Cardiovascular Drug Reviews 3:1, pages 153-172.
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R. Kolloch, KO Stumpe & A. Overlack. (2012) Blood pressure, heart rate and A‐V conduction responses to nicardipine in hypertensive patients receiving atenolol.. British Journal of Clinical Pharmacology 20:S1.
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Lars Weidolf. (1985) Bimodal column switching liquid chromatographic assay of six metabolites of [14C] felodipine in rat urine. Journal of Chromatography B: Biomedical Sciences and Applications 343, pages 85-97.
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B. Silke, R. C. Ahuja, R. C. Okoli, G. I. C. Nelson & S. H. Taylor. (1983) Blockade of slow calcium channels and regulation of circulatory pressor responses in uncomplicated hypertension. Irish Journal of Medical Science 152:10, pages 364-372.
Crossref
S. Higuchi & S. Kawamura. (1981) Specific determination of plasma nicardipine hydrochloride levels by gas chromatography—mass spectrometry. Journal of Chromatography B: Biomedical Sciences and Applications 223:2, pages 341-349.
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