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Xenobiotica
the fate of foreign compounds in biological systems
Volume 11, 1981 - Issue 1
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Research Article

Paracetamol and the isolated perfused kidney: Metabolism and functional effects

K. R. Emslie Departments of Pathology and Chemistry, University of Melbourne, Parkville, Victoria, 3052, Australia
,
M. C. Smail Departments of Pathology and Chemistry, University of Melbourne, Parkville, Victoria, 3052, Australia
,
I. C. Calder Departments of Pathology and Chemistry, University of Melbourne, Parkville, Victoria, 3052, Australia
,
S. J. Hart Departments of Pathology and Chemistry, University of Melbourne, Parkville, Victoria, 3052, Australia
&
J. D. Tange Departments of Pathology and Chemistry, University of Melbourne, Parkville, Victoria, 3052, Australia
Pages 43-50 | Received 02 Jan 1980, Published online: 22 Sep 2008

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Read on this site (5)

Peter H. Bach & Enoch N. Kwizera. (1988) Nephrotoxicity: A rational approach to target cell injury in vitro in the kidney. Xenobiotica 18:6, pages 685-698.
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Glenn F. Rush, Jacqueline H. Smith, John F. Newton, Jerry B. Hook & William O. Berndt. (1984) Chemically Induced Nephrotoxicity: Role of Metabolic Activation. CRC Critical Reviews in Toxicology 13:2, pages 99-160.
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Ihor Bekersky. (1983) Use of the Isolated Perfused Kidney as a Tool in Drug Disposition Studies. Drug Metabolism Reviews 14:5, pages 931-960.
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K. R. Emslie, I. C. Calder, S. J. Hart & J. D. Tange. (1982) Metabolism of paracetamol by the isolated perfused kidney of the homozygous Gunn rat. Xenobiotica 12:2, pages 77-82.
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K. R. Emslie, I. C. Calder, S. J. Hart & J. D. Tange. (1981) Induction of paracetamol metabolism in the isolated perfused kidney. Xenobiotica 11:9, pages 579-587.
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Articles from other publishers (11)

Wilfred Lieberthal. 2009. Critical Care Nephrology. Critical Care Nephrology 228 233 .
Kian Hong Ng, Beng Gek Lim & Kim Ping Wong. (2003) Sulfate conjugating and transport functions of MDCK distal tubular cells. Kidney International 63:3, pages 976-986.
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PETER H. BACH, DAVID K. OBATOMI & STEPHEN BRANT. 1997. In Vitro Methods in Pharmaceutical Research. In Vitro Methods in Pharmaceutical Research 55 cp2 .
W. O. Berndt. 1987. Nephrotoxicity in the experimental and clinical situation. Nephrotoxicity in the experimental and clinical situation 301 316 .
J.F. Newton, D.A. Pasino & J.B. Hook. (1985) Acetaminophen nephrotoxicity in the rat: Quantitation of renal metabolic activation in vivo. Toxicology and Applied Pharmacology 78:1, pages 39-46.
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Marilyn E. Morris & Gerhard Levyx. (1984) Renal Clearance and Serum Protein Binding of Acetaminophen and Its Major Conjugates in Humans. Journal of Pharmaceutical Sciences 73:8, pages 1038-1041.
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S.J. Hart, M.I. Aguilar, K. Healey, M.C. Smail & I.C. Calder. (1984) Improved high-performance liquid chromatographic separation of urinary paracetamol metabolites using radially compressed columns. Journal of Chromatography B: Biomedical Sciences and Applications 306, pages 215-229.
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J.F. Newton, M.B. Bailie & J.B. Hook. (1983) Acetaminophen nephrotoxicity in the rat. Renal metabolic activation in vitro. Toxicology and Applied Pharmacology 70:3, pages 433-444.
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J.F. Newton, M. Yoshimoto, J. Bernstein, G.F. Rush & J.B. Hook. (1983) Acetaminophen nephrotoxicity in the rat. Toxicology and Applied Pharmacology 69:2, pages 291-306.
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Ihor Bekersky. (1983) The isolated perfused kidney as a pharmacological tool. Trends in Pharmacological Sciences 4, pages 6-7.
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S.J. Hart, R. Tontodonati & I.C. Calder. (1981) Reversed-phase chromatography of urinary metabolites of paracetamol using ion suppression and ion pairing. Journal of Chromatography B: Biomedical Sciences and Applications 225:2, pages 387-405.
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