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Xenobiotica
the fate of foreign compounds in biological systems
Volume 11, 1981 - Issue 1
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Research Article

Irreversible protein binding of acrylonitrile

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Pages 51-56 | Received 07 May 1980, Published online: 22 Sep 2008

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Donald E. Nerland, Frederick W. Benz & Christine Babiuk. (1989) Effects of Cysteine Isomers and Derivatives on Acute Acrylonitrile Toxicity. Drug Metabolism Reviews 20:2-4, pages 233-246.
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H. Peter, K. E. Appel, R. Berg & H. M. Bolt. (1983) Irreversible binding of acrylonitrile to nucleic acids. Xenobiotica 13:1, pages 19-25.
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Articles from other publishers (29)

Vernon E. Walker, Dale M. Walker, Burhan I. Ghanayem & George R. Douglas. (2020) Analysis of Biomarkers of DNA Damage and Mutagenicity in Mice Exposed to Acrylonitrile. Chemical Research in Toxicology 33:7, pages 1623-1632.
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Vernon E. Walker, Timothy R. Fennell, Dale M. Walker, Michael J. Bauer, Patricia B. Upton, George R. Douglas & James A. Swenberg. (2020) Analysis of DNA Adducts and Mutagenic Potency and Specificity in Rats Exposed to Acrylonitrile. Chemical Research in Toxicology 33:7, pages 1609-1622.
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Gary M. Williams, Tetyana Kobets, Jian-Dong Duan & Michael J. Iatropoulos. (2017) Assessment of DNA Binding and Oxidative DNA Damage by Acrylonitrile in Two Rat Target Tissues of Carcinogenicity: Implications for the Mechanism of Action. Chemical Research in Toxicology 30:7, pages 1470-1480.
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Gabriele Leng & Jürgen Lewalter. (2002) Polymorphism of glutathione S-transferases and susceptibility to acrylonitrile and dimethylsulfate in cases of intoxication. Toxicology Letters 134:1-3, pages 209-217.
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R. Thier. 2001. Biological Reactive Intermediates VI. Biological Reactive Intermediates VI 587 594 .
J. Whysner, P.M. Ross, C.C. Conaway, L.K. Verna & G.M. Williams. (1998) Evaluation of Possible Genotoxic Mechanisms for Acrylonitrile Tumorigenicity. Regulatory Toxicology and Pharmacology 27:3, pages 217-239.
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Anne-Marie Saillenfait, Jean-Paul Payan, Isabelle Langonné, Dominique Beydon, Marie-Christine Grandclaude, Jean-Philippe Sabaté & Jacques de Ceaurriz. (1993) Modulation of acrylonitrile-induced embryotoxicity in vitro by glutathione depletion. Archives of Toxicology 67:3, pages 164-172.
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Mayo Uziel, Nancy B. Munro, D. Sue Katz, Tuan Vo-Dinh, Elaine A. Zeighami, Michael D. Waters & Jack D. Griffith. (1992) DNA adduct formation by 12 chemicals with populations potentially suitable for molecular epidemiological studies. Mutation Research/Reviews in Genetic Toxicology 277:1, pages 35-90.
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Pavel Vodička, Ivan Gut & Emil Frantík. (1990) Effects of inhaled acrylic acid derivatives in rats. Toxicology 65:1-2, pages 209-221.
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AHMED E. AHMED & GAMAL I. HUSSEIN. 1990. Nitrogen and Phosphorus Solvents. Nitrogen and Phosphorus Solvents 306 323 .
Frederick W. Benz, Donald E. Nerland, William M. Pierce & Christine Babiuk. (1990) Acute acrylonitrile toxicity: Studies on the mechanism of the antidotal effect of d- and l-cysteine and their N-acetyl derivatives in the rat. Toxicology and Applied Pharmacology 102:1, pages 142-150.
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G. M�ller, C. Verkoyen, N. Soton & K. Norpoth. (1987) Urinary excretion of acrylonitrile and its metabolites in rats. Archives of Toxicology 60:6, pages 464-466.
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M. Paolini, P. Hrelia, C. Corsi, G. Bronzetti, G.L. Biagi & G. Cantelli_Forti. (1987) NADPH as rate-limiting factor for microsomal metabolism an alternative and economic NADPH-generating system for microsomal mono-oxygenase in in vitro genotoxicity studies. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 178:1, pages 11-20.
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Hermann M. Bolt, Hans Peter & Hans-Jürgen Wiegand. 1986. Biological Reactive Intermediates III. Biological Reactive Intermediates III 1013 1016 .
Roger Deraedt, Claude Bonnat, Monique Busigny, Pierre Chatelet, Christian Cousty, Michel Mouren, Daniel Philibert, Jacques Pottier & Jean Salmon. 1985. The Antiprogestin Steroid RU 486 and Human Fertility Control. The Antiprogestin Steroid RU 486 and Human Fertility Control 103 122 .
M. Lambotte-Vandepaer & M. Duverger-van Bogaert. (1984) Genotoxic properties of acrylonitrile. Mutation Research/Reviews in Genetic Toxicology 134:1, pages 49-59.
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David W. Gottschall, Raymond R. Harder, Robert A. Wiley & Robert P. Hanzlik. (1984) Chemical models for toxic metabolites of bromobenzene derivatives. Relative toxicity toward isolated hepatocytes. Toxicology 31:3-4, pages 251-259.
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A. Buchter, H. Peter & H. M. Bolt. (1984) N-acetyl-cystein als antidot bei akzidenteller acrylnitril-intoxikationN-acetyl-cysteine as an antidote in accidental acrylonitrile intoxications. International Archives of Occupational and Environmental Health 53:4, pages 311-319.
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R. J. Jaeger, I. L. Cote, A. E. RogersE. H. SilverS. Szabo. (2016) Acute Toxicity of Acrylonitrile: Effect of Diet on Tissue Nonprotein Sulfhydryl Content and Distribution of 1– 14 C-Acrylonitrile or Its Metabolites . Journal of the American College of Toxicology 3:1, pages 93-102.
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Mohammed Y.H. Farooqui & Ahmed E. Ahmed. (1983) In vivo interactions of acrylonitrile with macromolecules in rats. Chemico-Biological Interactions 47:3, pages 363-371.
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M. Paolini, C. Bauer, C. Corsi, R. Del Carratore, R. Nieri & G. Bronzetti. (1983) Stability of microsomal mono-oxygenase during incubations for the liver microsomal assay with S9 fractions of mouse liver under various inductions. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 110:2, pages 221-230.
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Ahmed E. Ahmed, Mohammed Y. H. Farooqui, Raj K. Upreti & Osama El‐Shabrawy. (2006) Comparative toxicokinetics of 2,3‐ 14 C‐ and 1‐ 14 C‐acrylonitrile in the rat . Journal of Applied Toxicology 3:1, pages 39-47.
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M. Duverger-Van Bogaert, M. Lambotte-Vandepaer, M. Mercier & F. Poncelet. (1982) In vitro covalent binding of acrylonitrile to rat liver proteins. Toxicology Letters 13:3-4, pages 211-216.
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Mitsuru Sato, Fujiko Hirasawa, Masaru Ogata, Yukio Takizawa, Harumi Kojima & Tamao Yoshida. (1982) Distribution and accumulation of [2,3-14C]acrylonitrile in rat after single injection. Ecotoxicology and Environmental Safety 6:5, pages 489-494.
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E.H. Silver, D.J. McComb, K. Kovacs & S. Szabo. (1982) Limited hepatotoxic potential of acrylonitrile in rats. Toxicology and Applied Pharmacology 64:1, pages 131-139.
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. 1982. Aliphatic Carcinogens. Aliphatic Carcinogens 683 726 .
Ahmed E. Ahmed, Mohammed Y.H. Farooqui, Raj K. Upreti & Osama El-Shabrawy. (1982) Distribution and covalent interactions of [1-14C]acrylonitrile in the rat. Toxicology 23:2-3, pages 159-175.
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K. E. Appel, H. Peter & H. M. Bolt. (1981) Effect of potential antidotes on the acute toxicity of acrylonitrile. International Archives of Occupational and Environmental Health 49:2, pages 157-163.
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K.E. Appel, H. Peter, M. Bolt & H.M. Bolt. (1981) Interaction of acrylonitrile with hepatic microsomes of rats and men. Toxicology Letters 7:4-5, pages 335-339.
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