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Xenobiotica
the fate of foreign compounds in biological systems
Volume 11, 1981 - Issue 2
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Research Article

Identification of new urinary metabolites in man of quinine using methane chemical ionization gas chromatography-mass spectrometry

C. Liddle School of Physiology and Pharmacology University of New South Wales, P.O. Box 1, Kensington, NSW, 2033, Australia
,
G. G. Graham School of Physiology and Pharmacology University of New South Wales, P.O. Box 1, Kensington, NSW, 2033, Australia
,
R. K. Christopher Biomedical Mass Spectrometry Unit, University of New South Wales, P.O. Box 1, Kensington, NSW, 2033, Australia
,
S. Bhuwapathanapun Biomedical Mass Spectrometry Unit, University of New South Wales, P.O. Box 1, Kensington, NSW, 2033, Australia
&
A. M. Duffield Biomedical Mass Spectrometry Unit, University of New South Wales, P.O. Box 1, Kensington, NSW, 2033, Australia
Pages 81-87 | Received 27 Jun 1980, Published online: 22 Sep 2008

Citations (11)

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S. Wanwimolruk, S.M. Wong, H. Zhang & P.F. Coville. (1996) Simultaneous Determination of Quinine and a Major Metabolite 3-Hydroxyquinine in Biological Fluids by HPLC Without Extraction. Journal of Liquid Chromatography & Related Technologies 19:2, pages 293-305.
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O. O. Bolaji, C. P. Babalola & P. A. F. Dixon. (1991) Characterization of the principal metabolite of quinine in human urine by 1H-n.m.r. spectroscopy. Xenobiotica 21:4, pages 447-450.
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Articles from other publishers (9)

Sean R Marcsisin, Xiannu Jin, Theresa Bettger, Nicholas McCulley, Jason C Sousa, G Dennis Shanks, Babu L Tekwani, Rajnish Sahu, Gregory A Reichard, Richard J Sciotti, Victor Melendez & Brandon S Pybus. (2013) CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever. Malaria Journal 12:1.
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Marie-Clémence Verdier, Danièle Bentué-Ferrer & Olivier Tribut. (2011) Suivi thérapeutique pharmacologique de la quinine. Therapies 66:6, pages 507-516.
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Sompon Wanwimolruk, Suk-Ming Wong, Hu Zhang, Peter F Coville & Robert J Walker. (1995) Metabolism of Quinine in Man: Identification of a Major Metabolite, and Effects of Smoking and Rifampicin Pretreatment. Journal of Pharmacy and Pharmacology 47:11, pages 957-963.
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Eric Pussard, Alexandra Bernier, Elyane Fouquet & Patrice Bouree. (2003) Quinine distribution in mice withplasmodium berghei malaria. European Journal of Drug Metabolism and Pharmacokinetics 28:1, pages 11-20.
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Tao Zheng, Judith Flippen-Anderson, Peng Yu, Tao Wang, Rajaa Mirghani & James M. Cook. (2001) Stereocontrolled Conversion of Quinine into 10( R ),11-Dihydroxydihydroquinine via the Sharpless Osmylation Process . The Journal of Organic Chemistry 66:4, pages 1509-1511.
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Pierre Bannon, Peng Yu, James M Cook, Louise Roy & Jean-Pierre Villeneuve. (1998) Identification of quinine metabolites in urine after oral dosing in humans. Journal of Chromatography B: Biomedical Sciences and Applications 715:2, pages 387-393.
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Rajaa A. Mirghani, Örjan Ericsson & Lars L. Gustafsson. (1998) High-performance liquid chromatographic method for the determination of the major quinine metabolite, 3-hydroxyquinine, in plasma and urine. Journal of Chromatography B: Biomedical Sciences and Applications 708:1-2, pages 209-216.
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Y. Kuroiwa & T. Yoshida. 1997. Analytical Toxicology for Clinical, Forensic and Pharmaceutical Chemists. Analytical Toxicology for Clinical, Forensic and Pharmaceutical Chemists 621 662 .
Robert Verpoorte, Jan Schripsema & Theo van der Leer. 1989. 331 398 .

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