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Xenobiotica
the fate of foreign compounds in biological systems
Volume 11, 1981 - Issue 3
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Research Article

Metabolism of [14C]emodin in the rat

M. Bachmann Institut für Toxikologie der Eidgenössischen Technischen Hochschule und der Universität, Zürich, CH-8603, Schwerzenbach, Switzerland
&
Ch. Schlatter Institut für Toxikologie der Eidgenössischen Technischen Hochschule und der Universität, Zürich, CH-8603, Schwerzenbach, Switzerland
Pages 217-225 | Received 26 Aug 1980, Published online: 22 Sep 2008

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Guangyi Yang, Shufan Ge, Rashim Singh, Sumit Basu, Katherine Shatzer, Ming Zen, Jiong Liu, Yifan Tu, Chenning Zhang, Jinbao Wei, Jian Shi, Lijun Zhu, Zhongqiu Liu, Yuan Wang, Song Gao & Ming Hu. (2017) Glucuronidation: driving factors and their impact on glucuronide disposition. Drug Metabolism Reviews 49:2, pages 105-138.
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Feng Qin, Jun Huang, Xi Huang & Ping Ren. (2011) SIMULTANEOUS DETERMINATION AND PHARMACOKINETIC COMPARISONS OF ALOE-EMODIN, RHEIN, EMODIN, AND CHRYSOPHANOL AFTER ORAL ADMINISTRATION OF THESE MONOMERS, RHEI RHIZOMA AND CHAIQIN-CHENGQI-TANG, TO RATS. Journal of Liquid Chromatography & Related Technologies 34:14, pages 1381-1390.
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AdrianaM. Doi, RichardD. Irwin & JohnR. Bucher. (2005) Influence of Functional Group Substitutions on the Carcinogenicity of Anthraquinone in Rats and Mice: Analysis of Long-Term Bioassays by the National Cancer Institute and the National Toxicology Program. Journal of Toxicology and Environmental Health, Part B 8:2, pages 109-126.
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Sam Cherian, Kushvar Mammadova Hacisayidli, Renju Kurian & Allan Mathews. (2023) Therapeutically important bioactive compounds of the genus Polygonum L . and their possible interventions in clinical medicine . Journal of Pharmacy and Pharmacology 75:3, pages 301-327.
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Lianying Cheng, Jie Chen & Xiaofeng Rong. (2022) Mechanism of Emodin in the Treatment of Rheumatoid Arthritis. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-16.
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Dmitriy Berillo, Marzhan Kozhahmetova & Lina Lebedeva. (2022) Overview of the Biological Activity of Anthraquinons and Flavanoids of the Plant Rumex Species. Molecules 27:4, pages 1204.
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Karuna Singh & Ankita KumariKaruna Singh & Ankita Kumari. 2022. Mycotoxins and Mycotoxicoses. Mycotoxins and Mycotoxicoses 65 104 .
Hardeep Singh Tuli, Vaishali Aggarwal, Muobarak Tuorkey, Diwakar Aggarwal, Nidarshana Chaturvedi Parashar, Mehmet Varol, Raj Savla, Ginpreet Kaur, Sonam Mittal & Katrin Sak. (2021) Emodin: A metabolite that exhibits anti-neoplastic activities by modulating multiple oncogenic targets. Toxicology in Vitro 73, pages 105142.
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Vibha Shukla, Somya Asthana, Saurabh Singh & Anurag Tripathi. (2021) Role of anthraquinones in Cassia occidentalis induced hepato-myo-encephalopathy. Journal of Ethnopharmacology 267, pages 113431.
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Jinlan Yang, Shuo Wang, Tao Zhang, Yuqing Sun, Lifeng Han, Prince Osei Banahene & Qi Wang. (2021) Predicting the potential toxicity of 26 components in Cassiae semen using in silico and in vitro approaches. Current Research in Toxicology 2, pages 237-245.
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Dan Li, Mengbi Yang & Zhong Zuo. (2020) Overview of Pharmacokinetics and Liver Toxicities of Radix Polygoni Multiflori. Toxins 12:11, pages 729.
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Songyan Wu, Yaqing Zhang, Zunjian Zhang & Rui Song. (2017) Use of liquid chromatography hybrid triple-quadrupole mass spectrometry for the detection of emodin metabolites in rat bile and urine. Biomedical Chromatography 31:10, pages e3979.
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Li-Long Jiang, Dong-Sheng Zhao, Ya-Xi Fan, Qiong Yu, Ping Li & Hui-Jun Li. (2017) Detection of Emodin Derived Glutathione Adduct in Normal Rats Administered with Large Dosage of Polygoni Multiflori Radix. Frontiers in Pharmacology 8.
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B. Anu Monisha, Niraj Kumar & Ashu Bhan Tiku. 2016. Anti-inflammatory Nutraceuticals and Chronic Diseases. Anti-inflammatory Nutraceuticals and Chronic Diseases 47 73 .
Heyun Zhu, Kaishun Bi, Fei Han, Jiao Guan, Xiaoshu Zhang, Xinjuan Mao, Longshan Zhao, Qing Li, Xiaohong Hou & Ran Yin. (2015) Identification of the absorbed components and metabolites of Zhi-Zi-Da-Huang decoction in rat plasma by ultra-high performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 111, pages 277-287.
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Fang Fang, Jia-bo Wang, Yan-ling Zhao, Cheng Jin, Wei-jun Kong, Hai-ping Zhao, Hong-juan Wang & Xiao-he Xiao. (2011) A comparative study on the tissue distributions of rhubarb anthraquinones in normal and CCl4-injured rats orally administered rhubarb extract. Journal of Ethnopharmacology 137:3, pages 1492-1497.
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P de Witte & J Lemli. (1988) Excretion and distribution of [14C]rhein and [14C]rhein anthrone in rat. Journal of Pharmacy and Pharmacology 40:9, pages 652-655.
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Wei Liu, Lan Tang, Ling Ye, Zheng Cai, Bijun Xia, Jiajie Zhang, Ming Hu & Zhongqiu Liu. (2010) Species and Gender Differences Affect the Metabolism of Emodin via Glucuronidation. The AAPS Journal 12:3, pages 424-436.
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juan PENG, Zengfeng SONG & Chen MA. (2008) Emodin Studies on Pharmacokinetics and Distribution in Rat Liver after Polygonum cuspidatum Sieb. et Zucc. Extract Administration. World Science and Technology 10:1, pages 64-67.
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Bénédicte Vanderperren, Michela Rizzo, Luc Angenot, Vincent Haufroid, Michel Jadoul & Philippe Hantson. (2005) Acute Liver Failure with Renal Impairment Related to the Abuse of Senna Anthraquinone Glycosides. Annals of Pharmacotherapy 39:7-8, pages 1353-1357.
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Gloria D. Jahnke, Catherine J. Price, Melissa C. Marr, Christina B. Myers & Julia D. George. (2004) Developmental toxicity evaluation of emodin in rats and mice. Birth Defects Research Part B: Developmental and Reproductive Toxicology 71:2, pages 89-101.
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J. Westendorf. 1993. Adverse Effects of Herbal Drugs 2. Adverse Effects of Herbal Drugs 2 105 118 .
P. de Witte, A. van Hoestenberghe & H. Eyssen. (2006) In vitro reduction of rhein anthraquinone to rhein anthrone by rat cecal microflora and some intestinal bacterial strains . Biopharmaceutics & Drug Disposition 13:4, pages 243-253.
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Weici Tang & Gerhard EisenbrandWeici Tang & Gerhard Eisenbrand. 1992. Chinese Drugs of Plant Origin. Chinese Drugs of Plant Origin 855 875 .
L.E. Sendelbach. (1989) A review of the toxicity and carcinogenicity of anthraquinone derivatives. Toxicology 57:3, pages 227-240.
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David C. Lewis & Takayuki Shibamoto. (1989) Effects of Cassia obtusifolia (sicklepod) extracts and anthraquinones on muscle mitochondrial function. Toxicon 27:5, pages 519-529.
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Kawai Kiyoshi, Kato Taketoshi, Mori Hideki, Kitamura Jiro & Nozawa Yoshinori. (1984) A comparative study on cytotoxicities and biochemical properties of anthraquinone mycotoxins emodin and skyrin from Penicillium islandicum sopp. Toxicology Letters 20:2, pages 155-160.
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H. Poiger & H. R. Buser. 1983. Human and Environmental Risks of Chlorinated Dioxins and Related Compounds. Human and Environmental Risks of Chlorinated Dioxins and Related Compounds 483 492 .

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