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Xenobiotica
the fate of foreign compounds in biological systems
Volume 11, 1981 - Issue 5
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Research Article

Metabolism of 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline, a phenylethanolamine N-methyltransferase inhibitor. I. Disposition following administration to the rat and dog

A. P. Intoccia Research and Development Division, Smith Kline and French Laboratories, Division of Smith Kline Corporation, 1500 Spring Garden Street, Philadelphia, PA, 19101, USA
,
P. Levandoski Research and Development Division, Smith Kline and French Laboratories, Division of Smith Kline Corporation, 1500 Spring Garden Street, Philadelphia, PA, 19101, USA
,
G. Joseph Research and Development Division, Smith Kline and French Laboratories, Division of Smith Kline Corporation, 1500 Spring Garden Street, Philadelphia, PA, 19101, USA
,
R. Wittendorf Research and Development Division, Smith Kline and French Laboratories, Division of Smith Kline Corporation, 1500 Spring Garden Street, Philadelphia, PA, 19101, USA
,
C. Girman Research and Development Division, Smith Kline and French Laboratories, Division of Smith Kline Corporation, 1500 Spring Garden Street, Philadelphia, PA, 19101, USA
,
S. S. Walkenstein Research and Development Division, Smith Kline and French Laboratories, Division of Smith Kline Corporation, 1500 Spring Garden Street, Philadelphia, PA, 19101, USA
&
B. Y-H Hwang Research and Development Division, Smith Kline and French Laboratories, Division of Smith Kline Corporation, 1500 Spring Garden Street, Philadelphia, PA, 19101, USA
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Pages 301-309 | Received 21 Oct 1980, Published online: 22 Sep 2008

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William E. Bondinell, Frederic W. Chapin, James S. Frazee, Gerald R. Girard, Kenneth G. Holden, Carl Kaiser, Cynthia Maryanoff, Carl D. Perchonock, George W. Gessner, J. P. Hieble, Leonard M. Hillegass, Robert G. Pendleton & John L. Sawyer. (1983) Inhibitors of Phenylethanolamine N-Methyltransferase and Epinephrine Biosynthesis: A Potential Source of New Drugs. Drug Metabolism Reviews 14:4, pages 709-721.
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B. Y-H Hwang, G. Y. Kuo, Clara Miao & A. P. Intoccia. (1981) Metabolism of 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline, a phenylethanolamine N-methyltransferase inhibitor. II. Species difference in metabolism and synthesis of its metabolites. Xenobiotica 11:5, pages 311-318.
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