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Xenobiotica
the fate of foreign compounds in biological systems
Volume 11, 1981 - Issue 12
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Original Article

The use of on-line high-performance liquid chromatography-mass spectrometry for the identification of ranitidine and its metabolites in urine

L. E. Martin Department of Biochemical Pharmacology, Glaxo Group Research Limited, Ware, Herts., SG12 0DJ, UK
,
J. Oxford Department of Biochemical Pharmacology, Glaxo Group Research Limited, Ware, Herts., SG12 0DJ, UK
&
R. J. N. Tanner Department of Biochemical Pharmacology, Glaxo Group Research Limited, Ware, Herts., SG12 0DJ, UK
Pages 831-840 | Received 01 Nov 1981, Published online: 30 Sep 2009

Citations (21)

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Pat Wright. (2011) Metabolite identification by mass spectrometry: forty years of evolution. Xenobiotica 41:8, pages 670-686.
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J. A. Bell, A. Bradbury, L. E. Martin & R. J. N. Tanner. (1981) Applications of high-voltage paper electrophoresis for the characterization of drug metabolites. Xenobiotica 11:12, pages 841-847.
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Articles from other publishers (19)

F. Oesch, N. Honarvar, E. Fabian, F. I. Berger & Robert Landsiedel. (2021) N-vinyl compounds: studies on metabolism, genotoxicity, carcinogenicity. Archives of Toxicology 95:10, pages 3143-3159.
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Misha T. Elias, Jisha Chandran, Usha K. Aravind & Charuvila T. Aravindakumar. (2019) Oxidative degradation of ranitidine by UV and ultrasound: identification of transformation products using LC-Q-ToF-MS. Environmental Chemistry 16:1, pages 41.
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Christophoros Christophoridis, Maria-Christina Nika, Reza Aalizadeh & Nikolaos S. Thomaidis. (2016) Ozonation of ranitidine: Effect of experimental parameters and identification of transformation products. Science of The Total Environment 557-558, pages 170-182.
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Hugo Olvera-Vargas, Nihal Oturan, Enric Brillas, Didier Buisson, Giovanni Esposito & Mehmet A. Oturan. (2014) Electrochemical advanced oxidation for cold incineration of the pharmaceutical ranitidine: Mineralization pathway and toxicity evolution. Chemosphere 117, pages 644-651.
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Juan José Berzas Nevado, Gregorio Castañeda Peñalvo, Rosa Ma Rodríguez Dorado & Virginia Rodríguez Robledo. (2014) Determination of histamine H2 receptor antagonists in pharmaceutical formulations by CE-MS. Anal. Methods 6:6, pages 1714-1719.
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B Narayana, K Veena, K Ashwani & Divya. N Shetty. (2010) New reagents for the spectrophotometric determination of ranitidine hydrochloride. Eclética Química 35:3, pages 109-115.
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Jelena Radjenović, Carla Sirtori, Mira Petrović, Damià Barceló & Sixto Malato. (2010) Characterization of intermediate products of solar photocatalytic degradation of ranitidine at pilot-scale. Chemosphere 79:4, pages 368-376.
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Diane A.I. Ashiru, Rajesh Patel & Abdul W. Basit. (2007) Simple and universal HPLC-UV method to determine cimetidine, ranitidine, famotidine and nizatidine in urine: Application to the analysis of ranitidine and its metabolites in human volunteers. Journal of Chromatography B 860:2, pages 235-240.
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Ju-Hee Kang, Woon-Gye Chung, Kyung-Hoon Lee, Chang-Shin Park, Ju-Seop Kang, In-Chul Shin, Hyung-Keun Roh, Mi-Sook Dong, Hyun-Moon Baek & Young-Nam Cha. (2000) Phenotypes of flavin-containing monooxygenase activity determined by ranitidine N-oxidation are positively correlated with genotypes of linked FMO3 gene mutations in a Korean population. Pharmacogenetics 10:1, pages 67-78.
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Woon-Gye Chung, Chang-Shin Park, Hyung-Keun Roh, Woon-Kee Lee & Young-Nam Cha. (2000) Oxidation of Ranitidine by Isozymes of Flavin-Containing Monooxygenase and Cytochrome P450. Japanese Journal of Pharmacology 84:2, pages 213-220.
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Robin L. Davis, Ronald W. Quenzer, Haig P. BozigianChristopher W. Warner. (2016) Pharmacokinetics of Ranitidine in Morbidly Obese Women. DICP 24:11, pages 1040-1043.
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Kusuma R. Mallikaarjun & H.Thomas Karnes. (1990) Bioanalysis of anti-ulcer agents. Journal of Chromatography B: Biomedical Sciences and Applications 531, pages 407-420.
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Kenneth B. Tomer & Carol E. Parker. (1989) Biochemical applications of liquid chromatography-mass spectrometry. Journal of Chromatography B: Biomedical Sciences and Applications 492, pages 189-221.
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Thomayant Prueksaritanont, Nantana Sittichai, Somjit Prueksaritanont & Rewadee Vongsaroj. (1989) Simultaneous determination of ranitidine and its metabolites in human plasma and urine by high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications 490, pages 175-185.
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Marijan Hohnjec, Josip Kuftinec, Miljenka Malnar, Milivoj Škreblin, Franjo Kajfež, Antun Nagl & Nikola Blažević. 1986. 533 561 .
M.S. Lant, L.E. Martin & J. Oxford. (1985) Qualitative and quantitative analysis of ranitidine and its metabolites by high-performance liquid chromatography—mass spectrometry. Journal of Chromatography A 323:1, pages 143-152.
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L. E. Martin, Janet Oxford, D. Dixon & R. Schuster. 1985. Drug Determination in Therapeutic and Forensic Contexts. Drug Determination in Therapeutic and Forensic Contexts 191 194 .
Timothy S. Gaginella & Jay H. Bauman. (2016) Ranitidine Hydrochloride. Drug Intelligence & Clinical Pharmacy 17:12, pages 873-885.
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James A. Apffel, Udo A. T. Brinkman, Roland W. Frei & Evert A. I. M. Evers. (2002) Gas-nebulized direct liquid introduction interface for liquid chromatography/mass spectrometry. Analytical Chemistry 55:14, pages 2280-2284.
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