Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 11, 1981 - Issue 8
85
Views
38
CrossRef citations to date
0
Altmetric
Research Article

The pharmacokinetics of saccharin in man

, &
Pages 531-540 | Received 01 May 1981, Published online: 22 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

A. G. Renwick. (1993) A data‐derived safety (uncertainty) factor for the intense sweetener, saccharin. Food Additives & Contaminants 10:3, pages 337-350.
Read now
A. G. Renwick. (1991) Safety factors and establishment of acceptable daily intakes. Food Additives & Contaminants 8:2, pages 135-149.
Read now

Articles from other publishers (36)

Sudarshan Singh & Warangkana ChunglokSudarshan Singh & Warangkana Chunglok. 2022. Biopolymers Towards Green and Sustainable Development. Biopolymers Towards Green and Sustainable Development 168 181 .
Jotham Suez, Yotam Cohen, Rafael Valdés-Mas, Uria Mor, Mally Dori-Bachash, Sara Federici, Niv Zmora, Avner Leshem, Melina Heinemann, Raquel Linevsky, Maya Zur, Rotem Ben-Zeev Brik, Aurelie Bukimer, Shimrit Eliyahu-Miller, Alona Metz, Ruthy Fischbein, Olga Sharov, Sergey Malitsky, Maxim Itkin, Noa Stettner, Alon Harmelin, Hagit Shapiro, Christoph K. Stein-Thoeringer, Eran Segal & Eran Elinav. (2022) Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance. Cell 185:18, pages 3307-3328.e19.
Crossref
Sarah J Zyba, Valerie Weinborn, Charles D Arnold, Arlie L Lehmkuhler, Fanny B Morel, Mamane Zeilani, Alyson E Mitchell & Marjorie J Haskell. (2021) Evaluation of Saccharin and Resveratrol as Extrinsic Markers of Small-Quantity Lipid-Based Nutrient Supplement Consumption in Healthy Women. Current Developments in Nutrition 5:7, pages nzab089.
Crossref
Caomhan Logue, Le Roy C Dowey, Hans Verhagen, JJ Strain, Maeve O'Mahony, Maria Kapsokefalou, Adelais Athanasatou & Alison M Gallagher. (2020) A Novel Urinary Biomarker Approach Reveals Widespread Exposure to Multiple Low-CalorieSweeteners in Adults. The Journal of Nutrition 150:9, pages 2435-2441.
Crossref
Polina Lizunkova, Emmanuella Enuwosa & Havovi Chichger. (2018) Activation of the sweet taste receptor T1R3 by sucralose attenuates VEGF-induced vasculogenesis in a cell model of the retinal microvascular endothelium. Graefe's Archive for Clinical and Experimental Ophthalmology 257:1, pages 71-81.
Crossref
Joseph A. Rothwell, Francisco Madrid-Gambin, Mar Garcia-Aloy, Cristina Andres-Lacueva, Caomhan Logue, Alison M. Gallagher, Carina Mack, Sabine E. Kulling, Qian Gao, Giulia Praticò, Lars O. Dragsted & Augustin Scalbert. (2018) Biomarkers of intake for coffee, tea, and sweetened beverages. Genes & Nutrition 13:1.
Crossref
Elizabeth O. Harrington, Alexander Vang, Julie Braza, Aparna Shil & Havovi Chichger. (2018) Activation of the sweet taste receptor, T1R3, by the artificial sweetener sucralose regulates the pulmonary endothelium. American Journal of Physiology-Lung Cellular and Molecular Physiology 314:1, pages L165-L176.
Crossref
Caomhan Logue, Le Roy C. Dowey, J. J. Strain, Hans Verhagen, Stephen McClean & Alison M. Gallagher. (2017) Application of Liquid Chromatography–Tandem Mass Spectrometry To Determine Urinary Concentrations of Five Commonly Used Low-Calorie Sweeteners: A Novel Biomarker Approach for Assessing Recent Intakes?. Journal of Agricultural and Food Chemistry 65:22, pages 4516-4525.
Crossref
Marilena Colaianna, Sten Ilmjärv, Hedi Peterson, Ilse Kern, Stephanie Julien, Mathurin Baquié, Giorgia Pallocca, Sieto Bosgra, Agapios Sachinidis, Jan G. Hengstler, Marcel Leist & Karl-Heinz Krause. (2016) Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay. Archives of Toxicology 91:1, pages 365-391.
Crossref
Jan Vymazal & Tereza Dvořáková Březinová. (2016) Removal of saccharin from municipal sewage: The first results from constructed wetlands. Chemical Engineering Journal 306, pages 1067-1070.
Crossref
Bernadene A. Magnuson, Michael C. Carakostas, Nadia H. Moore, Sylvia P. Poulos & Andrew G. Renwick. (2016) Biological fate of low-calorie sweeteners. Nutrition Reviews 74:11, pages 670-689.
Crossref
C. Logue, L. C. Dowey, J. J. Strain, H. Verhagen & A. M. Gallagher. (2016) The potential application of a biomarker approach for the investigation of low-calorie sweetener exposure. Proceedings of the Nutrition Society 75:2, pages 216-225.
Crossref
C. Fitch. 2016. Encyclopedia of Food and Health. Encyclopedia of Food and Health 659 664 .
John D. Fernstrom. (2015) Non-Nutritive Sweeteners and Obesity. Annual Review of Food Science and Technology 6:1, pages 119-136.
Crossref
Thorsteinn Loftsson. (2015) Excipient pharmacokinetics and profiling. International Journal of Pharmaceutics 480:1-2, pages 48-54.
Crossref
Thorsteinn Loftsson. 2015. Essential Pharmacokinetics. Essential Pharmacokinetics 85 104 .
George P. Daston, Bruce K. Beyer, Edward W. Carney, Robert E. Chapin, Jan M. Friedman, Aldert H. Piersma, John M. Rogers & Anthony R. Scialli. (2014) Exposure‐Based Validation List for Developmental Toxicity Screening Assays. Birth Defects Research Part B: Developmental and Reproductive Toxicology 101:6, pages 423-428.
Crossref
Sebastian D. Parlee, Becky R. Simon, Erica L. Scheller, Emilyn U. Alejandro, Brian S. Learman, Venkatesh Krishnan, Ernesto Bernal-Mizrachi & Ormond A. MacDougald. (2014) Administration of Saccharin to Neonatal Mice Influences Body Composition of Adult Males and Reduces Body Weight of Females. Endocrinology 155:4, pages 1313-1326.
Crossref
John D. Fernstrom. 2014. Fructose, High Fructose Corn Syrup, Sucrose and Health. Fructose, High Fructose Corn Syrup, Sucrose and Health 63 84 .
Becky R. Simon, Sebastian D. Parlee, Brian S. Learman, Hiroyuki Mori, Erica L. Scheller, William P. Cawthorn, Xiaomin Ning, Katherine Gallagher, Björn Tyrberg, Fariba M. Assadi-Porter, Charles R. Evans & Ormond A. MacDougald. (2013) Artificial Sweeteners Stimulate Adipogenesis and Suppress Lipolysis Independently of Sweet Taste Receptors. Journal of Biological Chemistry 288:45, pages 32475-32489.
Crossref
Ashley Roberts & Andrew G. Renwick. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
Manfred Kroger, Kathleen Meister & Ruth Kava. (2006) Low‐calorie Sweeteners and Other Sugar Substitutes: A Review of the Safety Issues. Comprehensive Reviews in Food Science and Food Safety 5:2, pages 35-47.
Crossref
Yuan H. Zhao, Joelle Le, Michael H. Abraham, Anne Hersey, Peter J. Eddershaw, Chris N. Luscombe, Darko Boutina, Gordon Beck, Brad Sherborne, Ian Cooper & James A. Platts. (2001) Evaluation of human intestinal absorption data and subsequent derivation of a quantitative structure–activity relationship (QSAR) with the Abraham descriptors. Journal of Pharmaceutical Sciences 90:6, pages 749-784.
Crossref
David J. Ager, David P. Pantaleone, Scott A. Henderson, Alan R. Katritzky, Indra Prakash & D. Eric Walters. (1998) Synthetische nichtnutritive Süßstoffe. Angewandte Chemie 110:13-14, pages 1900-1916.
Crossref
F. M. Macdonald & V. M. Lingard. 1993. Dictionary of Analytical Reagents. Dictionary of Analytical Reagents 858 870 .
Clifford I. Chappel. (1992) A review and biological risk assessement of sodium saccharin. Regulatory Toxicology and Pharmacology 15:3, pages 253-270.
Crossref
J. Elks & C. R. Ganellin. 1990. Dictionary of Drugs. Dictionary of Drugs 1086 1144 .
C.A. Lawrie & A.G. Renwick. (1987) The effect of saccharin ingestion on the excretion of microbial amino acid metabolites in rat and man. Toxicology and Applied Pharmacology 91:3, pages 415-428.
Crossref
Barbara A. Brennessel & Kathleen J. Keyes. (1985) Saccharin induces morphological changes and enhances prolactin production in GH4C1 cells. In Vitro Cellular & Developmental Biology 21:7, pages 402-408.
Crossref
A. Roberts & A.G. Renwick. (1985) The effect of saccharin on the microbial metabolism of tryptophan in man. Food and Chemical Toxicology 23:4-5, pages 451-455.
Crossref
A.G. Renwick. (1985) The disposition of saccharin in animals and man—A review. Food and Chemical Toxicology 23:4-5, pages 429-435.
Crossref
A.G. Renwick. (1985) The fate of intense sweeteners in the body. Food Chemistry 16:3-4, pages 281-301.
Crossref
J. Sims & A.G. Renwick. (1984) Diurnal variation in the excretion of indican in rats fed saccharin containing diet. Cancer Letters 23:3, pages 259-263.
Crossref
Harold C. Grice. 1984. Interpretation and Extrapolation of Chemical and Biological Carcinogenicity Data to Establish Human Safety Standards. Interpretation and Extrapolation of Chemical and Biological Carcinogenicity Data to Establish Human Safety Standards 1 152 .
J. L. Byard. 1984. Nutritional and Toxicological Aspects of Food Safety. Nutritional and Toxicological Aspects of Food Safety 147 151 .
D.L. Arnold, D. Krewski & I.C. Munro. (1983) Saccharin: A toxicological and historical perspective. Toxicology 27:3-4, pages 179-256.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.