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Xenobiotica
the fate of foreign compounds in biological systems
Volume 11, 1981 - Issue 8
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Research Article

The metabolic fate of 1′,2′-epoxyhexobarbital in the rat

N. P. E. Vermeulen Department of Pharmacology, University of Leiden, Gorlaeus Laboratories, P.O. Box 9502, 2300 RA, Leiden, The Netherlands; Department of Pharmaceutical Analysis, University of Leiden, Gorlaeus Laboratories, P.O. Box 9502, 2300 RA, Leiden, The Netherlands
,
D. D. Breimer Department of Pharmacology, University of Leiden, Gorlaeus Laboratories, P.O. Box 9502, 2300 RA, Leiden, The Netherlands
,
J. Holthuis Department of Pharmacology, University of Leiden, Gorlaeus Laboratories, P.O. Box 9502, 2300 RA, Leiden, The Netherlands
,
C. Mol Department of Pharmacology, University of Leiden, Gorlaeus Laboratories, P.O. Box 9502, 2300 RA, Leiden, The Netherlands
,
B. H. Bakker Department of Organic Chemistry, University of Leiden, Gorlaeus Laboratories, P.O. Box 9502, 2300 RA, Leiden, The Netherlands
&
A. Van Der Gen Department of Organic Chemistry, University of Leiden, Gorlaeus Laboratories, P.O. Box 9502, 2300 RA, Leiden, The Netherlands
Pages 547-557 | Received 10 Mar 1981, Published online: 22 Sep 2008

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R. Takenoshita, T. Nakamura & S. Toki. (1993) Hexobarbital metabolism: a new metabolic pathway to produce 1,5-dimethylbarbituric acid and cyclohexenone-glutathione adduct via 3′-oxohexobarbital. Xenobiotica 23:8, pages 925-934.
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M. Van Der Graaff, N. P. E. Vermeulen & D. D. Breimer. (1988) Disposition of hexobarbital: 15 years of an intriguing model substrate. Drug Metabolism Reviews 19:2, pages 109-164.
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