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Xenobiotica
the fate of foreign compounds in biological systems
Volume 11, 1981 - Issue 9
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Research Article

The metabolic fate of [3H]econazole in man

I. Midgley Department of Metabolism, Pharmacokinetics, Huntingdon Research Centre, Huntingdon, PE18 6ES, UK
,
S. R. Biggs Department of Metabolism, Pharmacokinetics, Huntingdon Research Centre, Huntingdon, PE18 6ES, UK
,
D. R. Hawkins Department of Metabolism, Pharmacokinetics, Huntingdon Research Centre, Huntingdon, PE18 6ES, UK
,
L. F. Chasseaud Department of Metabolism, Pharmacokinetics, Huntingdon Research Centre, Huntingdon, PE18 6ES, UK
,
A. Darragh The Institute of Pharmacology and Metabolism, St James' Hospital, Dublin, Eire
,
R. R. Brodie Department of Metabolism, Pharmacokinetics, Huntingdon Research Centre, Huntingdon, PE18 6ES, UK
&
L. M. Walmsley Department of Metabolism, Pharmacokinetics, Huntingdon Research Centre, Huntingdon, PE18 6ES, UK
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Pages 595-608 | Received 23 Apr 1981, Published online: 22 Sep 2008

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Himanshi Khera, Avaneesh Kumar Pandey, Nusrat Shafiq, G.K. Khuller, Ritika Kondel Bhandari, Aditi Panditrao, Nanda Gamad, Rachna Rohilla, Samiksha Bhattacharjee, Naveen Murali, Harish cvn, Devraj Belavagi, Chakrant Mothsara, Manjula Singh, Navneet Sharma, Digamber Behera & Samir Malhotra. (2022) Single ascending dose safety, tolerability, and pharmacokinetic study of econazole in healthy volunteers. Expert Review of Anti-infective Therapy 20:6, pages 955-961.
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S. Tachibana, M. Tanaka, Y. Fujimaki, W. Suzuki, T. Ookuma, Y. Ohori, K.-I. Hayashi, H. Iwata, O. Okazaki & K.-I. Sudo. (2005) Metabolism of the calmodulin antagonist DY-9760e in animals and humans. Xenobiotica 35:5, pages 499-517.
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Laura Kragie, Stephanie D. Turner, Christopher J. Patten, Charles L. Crespi & David M. Stresser. (2002) ASSESSING PREGNANCY RISKS OF AZOLE ANTIFUNGALS USING A HIGH THROUGHPUT AROMATASE INHIBITION ASSAY. Endocrine Research 28:3, pages 129-140.
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W. R. Rush, D. J. Hall, D. J. M. Graham & I. A. Selby. (1992) The metabolism of imiloxan hydrochloride in healthy male volunteers. Xenobiotica 22:2, pages 237-246.
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M. Nakano, M. Takeuchi, S. Kawahara & K. Mizojiri. (1990) Croconazole metabolism in rats. Xenobiotica 20:4, pages 385-393.
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W. R. Rush, O. F. Alexander, D. J. Hall, R. J. Dow, L. Tokes, L. Kurz & D. J. M. Graham. (1990) The metabolism of nafimidone hydrochloride in the dog, primates and man. Xenobiotica 20:1, pages 123-132.
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M. Takeuchi, M. Nakano, K. Mizojiri, K. Iwatani, Y. Nakagawa, J. Kikuchi & Y. Terui. (1989) Quaternary ammonium glucuronide of croconazole in rabbits. Xenobiotica 19:11, pages 1327-1336.
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Nora Karaoun & Anna K. Renfrew. (2015) A luminescent ruthenium( ii ) complex for light-triggered drug release and live cell imaging . Chemical Communications 51:74, pages 14038-14041.
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Yuan-Soon Ho, Chih-Hsiung Wu, Hsiao-Min Chou, Ying-Jan Wang, How Tseng, Chien-Ho Chen, Li-Ching Chen, Chia-Hwa Lee & Shyr-Yi Lin. (2005) Molecular mechanisms of econazole-induced toxicity on human colon cancer cells: G0/G1 cell cycle arrest and caspase 8-independent apoptotic signaling pathways. Food and Chemical Toxicology 43:10, pages 1483-1495.
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Hiroyuki Miyachi & Yoshio Nagatsu. (2002) Biomimetic Oxidation of 2-Methylimidazole Derivative with a Chemical Model System for Cytochrome P-450. CHEMICAL & PHARMACEUTICAL BULLETIN 50:8, pages 1137-1140.
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A. Mark Dyas & Hugh Delargy. 1994. 125 151 .
F. von Bruchhausen, S. Ebel, E. Hackenthal, G. Dannhardt, A. W. Frahm, U. Holzgrabe, K. Keller, E. Nürnberg, H. Rimpler, G. Schneider, P. Surmann, H. U. Wolf & G. Wurm. 1993. Hagers Handbuch der Pharmazeutischen Praxis. Hagers Handbuch der Pharmazeutischen Praxis 1 163 .
Michael H. Tarbit. 1990. Chemotherapy of Fungal Diseases. Chemotherapy of Fungal Diseases 183 204 .
J. Elks & C. R. Ganellin. 1990. Dictionary of Drugs. Dictionary of Drugs 476 531 .
A.D. Rodrigues, G.G. Gibson, C. Ioannides & D.V. Parke. (1987) Interactions of imidazole antifungal agents with purified cytochrome P-450 proteins. Biochemical Pharmacology 36:24, pages 4277-4281.
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R. Girkin, R. R. Brodie, I. Midgley, D. R. Hawkins & L. F. Chasseaud. (1983) Comparison of the plasma and urinary metabolites of [3H]-econazole nitrate in the monkey and pregnant and non-pregnant rat. European Journal of Drug Metabolism and Pharmacokinetics 8:2, pages 109-116.
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