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Xenobiotica
the fate of foreign compounds in biological systems
Volume 11, 1981 - Issue 9
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Research Article

The metabolism of [2-14C]methimazole in the rat

G. G. Skellern Drug Metabolism Research Unit, Department of Pharmaceutical Chemistry, University of Strathclyde, Glasgow, G1 1XW, UK
&
S. T. Steer Drug Metabolism Research Unit, Department of Pharmaceutical Chemistry, University of Strathclyde, Glasgow, G1 1XW, UK
Pages 627-634 | Received 05 May 1981, Published online: 22 Sep 2008

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Reza Heidari, Hossein Babaei & Mohammad Eghbal. (2013) Mechanisms of methimazole cytotoxicity in isolated rat hepatocytes. Drug and Chemical Toxicology 36:4, pages 403-411.
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T. G. ALTUNTAS & J. W. GORROD. (1997) Comutagenesis-III. In vitro metabolism of 2-amino3-methylpyridine : the effect of various potential inhibitors, activators and inducers. Xenobiotica 27:11, pages 1103-1111.
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T. G. Altunas & J. W. Gorrod. (1996) Effect of various potential inhibitors, activators and inducers on the N-oxidation of isomeric aromatic diazines in vitro using rabbit liver microsomal preparations. Xenobiotica 26:1, pages 9-15.
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H. Sayo & M. Saito. (1991) Hydrogen peroxide-dependent oxidative metabolism of 1-methy1-2-mercaptoimidazole (methimazole) catalysed by myeloperoxidase. Xenobiotica 21:9, pages 1217-1224.
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Daniel S. Sitar. (1990) Metabolism of Thioamide Antithyroid Drugs. Drug Metabolism Reviews 22:5, pages 477-502.
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Articles from other publishers (9)

Kudzanai Chipiso & Reuben H. Simoyi. (2016) Kinetics and Mechanism of Oxidation of Methimazole by Chlorite in Slightly Acidic Media. The Journal of Physical Chemistry A 120:21, pages 3767-3779.
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Stijn L J Van Herck, Stijn Geysens, Edward Bald, Grazyna Chwatko, Evelyne Delezie, Elham Dianati, R G Ahmed & Veerle M Darras. (2013) Maternal transfer of methimazole and effects on thyroid hormone availability in embryonic tissues. Journal of Endocrinology 218:1, pages 105-115.
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Fei Dong, Kewang Hu, Heyou Han & Jiangong Liang. (2008) A novel method for methimazole determination using CdSe quantum dots as fluorescence probes. Microchimica Acta 165:1-2, pages 195-201.
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Tamio Mizutani, Mihoko Murakami, Mutsuko Shirai, Maki Tanaka & Kazuo Nakanishi. (1999) Metabolism-dependent hepatotoxicity of methimazole in mice depleted of glutathione. Journal of Applied Toxicology 19:3, pages 193-198.
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Ding Y. Liu & John W. Gorrod. (1999) INDUCTION AND INHIBITION OF THE IN VITRO Ν1-OXIDATION OF 9-BENZYLADENINE AND ISOMERIC 9-(NITROBENZYL)ADENINES. Drug Metabolism and Drug Interactions 15:2-3.
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J. Buckingham. 1990. Dictionary of Organic Compounds. Dictionary of Organic Compounds 98 172 .
J. Elks & C. R. Ganellin. 1990. Dictionary of Drugs. Dictionary of Drugs 344 475 .
John R. Paterson, Hugh T. Hood & Graham G. Skellern. (1983) The role of porcine thyroid peroxidase and FAD-containing monooxygenase in the metabolism of 1-methyl-2-thioimidazole (methimazole). Biochemical and Biophysical Research Communications 116:2, pages 449-455.
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Hugh T. Hood & Graham G. Skellern. (2006) The synthesis of 3‐methyl‐2‐[4‐ 14 C]thiohydantoin a pharmacologically active metabolite of the antithyroid drug methimazole . Journal of Labelled Compounds and Radiopharmaceuticals 19:6, pages 779-782.
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