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Xenobiotica
the fate of foreign compounds in biological systems
Volume 12, 1982 - Issue 8
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Research Article

Species differences in the metabolic C- and N-oxidation, and N-methylation of [14C]pyridine in vivo

L. A. Damani Drug Metabolism and Toxicology Group, Department of Pharmacy, University of Manchester, Manchester, M13 9PL, UK
,
P. A. Crooks Drug Metabolism and Toxicology Group, Department of Pharmacy, University of Manchester, Manchester, M13 9PL, UK; College of Pharmacy, University of Kentucky, Lexington, Kentucky, 40506, USA
,
M. S. Shaker Drug Metabolism and Toxicology Group, Department of Pharmacy, University of Manchester, Manchester, M13 9PL, UK
,
J. Caldwell Department of Biochemical and Experimental Pharmacology, St Mary's Hospital Medical School, Paddington, London, W2 1PG, UK
,
J. D'souza Department of Biochemical and Experimental Pharmacology, St Mary's Hospital Medical School, Paddington, London, W2 1PG, UK
&
R. L. Smith Department of Biochemical and Experimental Pharmacology, St Mary's Hospital Medical School, Paddington, London, W2 1PG, UK
Pages 527-534 | Received 12 Mar 1982, Published online: 22 Sep 2008

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D. McKillop, K. J. Pickup, A. J. Swaisland & B. F. Holmes. (1990) The metabolic disposition of an orally active pyridyl thiadiazinone cardiotonic agent (MPTD) in rat and baboon. Xenobiotica 20:4, pages 401-415.
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Raymond f. Novak, Karen l. Kaul & Sang Geon Kim. (1989) Induction of the Alcohol Inducible Form of Cytochrome P-450 By Nitrogen-Containing Heterocycles: Effects on Pyridine It-Oxide Production. Drug Metabolism Reviews 20:2-4, pages 781-792.
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T. J. Wilke, W. R. Jondorf & G. Powis. (1989) Oxidative metabolism of 14C-pyridine by human and rat tissue subcellular fractions. Xenobiotica 19:9, pages 1013-1022.
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GeraldK. Sims, EdwardJ. O'Loughlin & RonaldL. Crawford. (1989) Degradation of pyridines in the environment. Critical Reviews in Environmental Control 19:4, pages 309-340.
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L. A. Damani, M. S. Shaker, P. A. Crooks, C. S. Godin & C. Nwosu. (1986) N-Methylation and quaternization of pyridine in vitro by rabbit lung, liver and kidney N-methyltransferases: an S-adenosy1-L-methioninedependent reaction. Xenobiotica 16:7, pages 645-650.
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Andrii Lozynskyi, Yulian Konechnyi, Julia Senkiv, Ihor Yushyn, Dmytro Khyluk, Olexandr Karpenko, Yulia Shepeta & Roman Lesyk. (2021) Synthesis and Biological Activity Evaluation of Novel 5-Methyl-7-phenyl-3H-thiazolo[4,5-b]pyridin-2-ones. Scientia Pharmaceutica 89:4, pages 52.
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Justas Vaitekūnas, Renata Gasparavičiūtė, Jonita Stankevičiūtė, Gintaras Urbelis & Rolandas Meškys. (2020) Biochemical and Genetic Analysis of 4-Hydroxypyridine Catabolism in Arthrobacter sp. Strain IN13. Microorganisms 8:6, pages 888.
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Vytautas Petkevičius, Justas Vaitekūnas, Jonita Stankevičiūtė, Renata Gasparavičiūtė & Rolandas Meškys. (2018) Catabolism of 2-Hydroxypyridine by Burkholderia sp. Strain MAK1: a 2-Hydroxypyridine 5-Monooxygenase Encoded by hpdABCDE Catalyzes the First Step of Biodegradation . Applied and Environmental Microbiology 84:11.
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Clemente Bretti, Rosalia Maria Cigala, Concetta De Stefano, Gabriele Lando & Silvio Sammartano. (2013) Thermodynamics for Proton Binding of Pyridine in Different Ionic Media at Different Temperatures. Journal of Chemical & Engineering Data 59:1, pages 143-156.
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Gerald L. KennedyJr.Jr.. 2003. Patty's Toxicology. Patty's Toxicology 1 158 .
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 19 .
. 2002. The MAK-Collection for Occupational Health and Safety. The MAK-Collection for Occupational Health and Safety 1 318 .
L A Damani, M S Shaker, C S Godin, P A Crooks, S S Ansher & W B Jakoby. (1986) The ability of amine N -methyltransferases from rabbit liver to N -methylate azaheterocycles . Journal of Pharmacy and Pharmacology 38:7, pages 547-550.
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Zvi RappoportPeter Hlavica & Michael Lehnerer. 2010. Patai's Chemistry of Functional Groups. Patai's Chemistry of Functional Groups.
René Ullrich, Christoph Dolge, Martin Kluge & Martin Hofrichter. (2008) Pyridine as novel substrate for regioselective oxygenation with aromatic peroxygenase from Agrocybe aegerita . FEBS Letters 582:29, pages 4100-4106.
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Karen L. Ericson, Vincent M. Maloney, J. Dennis Mahuren, Stephen P. Coburn & Thorsten P. Degenhardt. (2008) N-Methylpyridoxamine: Novel canine vitamin B6 urine metabolite. Bioorganic & Medicinal Chemistry Letters 18:6, pages 1845-1848.
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María L. Dell'Arciprete, Carlos J. Cobos, Jorge P. Furlong, Daniel O. Mártire & Mónica C. Gonzalez. (2007) Reactions of Sulphate Radicals with Substituted Pyridines: A Structure–Reactivity Correlation Analysis. ChemPhysChem 8:17, pages 2498-2505.
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Michael M Iba, Truyen Nguyen & Jacqueline Fung. (2002) CYP1A1 induction by pyridine and its metabolites in HepG2 cells. Archives of Biochemistry and Biophysics 404:2, pages 326-334.
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Michael M. Iba, Jacqueline Fung, John V. Giannone & Allan B. Okey. (2000) Comparative Induction of CYP1A1 Expression by Pyridine and Its Metabolites. Archives of Biochemistry and Biophysics 378:2, pages 299-310.
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Gary P. Carlson. (1996) Comparison of the effects of pyridine and its metabolites on rat liver and kidney. Toxicology Letters 85:3, pages 173-178.
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RALPH L. REED. 1990. Nitrogen and Phosphorus Solvents. Nitrogen and Phosphorus Solvents 259 267 .
. 1989. Metabolic Maps of Pesticides. Metabolic Maps of Pesticides 244 255 .
Peter A. Crooks, C.Steven Godin, Lyaquatali A. Damani, Sherry S. Ansher & William B. Jakoby. (1988) Formation of quaternary amines by N- methylation of azaheterocycles with homogeneous amine n-methyltransferases. Biochemical Pharmacology 37:9, pages 1673-1677.
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L.Λ. Damani. (1988) CHEMICAL REACTIVITY CONSIDERATIONS IN THE METABOLISM OF N-HETEROAROMATICS. Drug Metabolism and Drug Interactions 6:2.
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P.A.F. Dixon, S.E. Okereke & M.C.N. Enwelum. (1985) Influence of species, sex and drug pretreatment on the metabolism of metyrapone. Comparative Biochemistry and Physiology Part C: Comparative Pharmacology 81:1, pages 241-243.
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Kenneth C. Cundy, C.Steven Godin & Peter A. Crooks. (1985) Stereospecific in vitro N-methylation of nicotine in guinea pig tissues by an S-adenosylmethionine-dependent N-methyltransferase. Biochemical Pharmacology 34:2, pages 281-284.
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K.C. Cundy & P.A. Crooks. (1984) High-performance liquid chromatographic method for the determination of N-methylated metabolites of nicotine. Journal of Chromatography B: Biomedical Sciences and Applications 306, pages 291-301.
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. 1984. Comprehensive Heterocyclic Chemistry. Comprehensive Heterocyclic Chemistry 673 731 .
L.A. Damani & D.E. Case. 1984. Comprehensive Heterocyclic Chemistry. Comprehensive Heterocyclic Chemistry 223 246 .

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