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Xenobiotica
the fate of foreign compounds in biological systems
Volume 12, 1982 - Issue 9
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Research Article

The metabolic fate of 4-amino-2-(4-butanoyl-hexahydro-1H-1, 4-diazepin-1-y1)-6, 7-dimethoxy-quinazoline HCI

C. Yamato Tsukuba Research Laboratories, Eisai Co. Ltd, Tokodai 5, Toyosato-machi, Tsukuba-gun, Ibaragi, Japan
,
T. Takahashi Tsukuba Research Laboratories, Eisai Co. Ltd, Tokodai 5, Toyosato-machi, Tsukuba-gun, Ibaragi, Japan
,
K. Kinoshita Tsukuba Research Laboratories, Eisai Co. Ltd, Tokodai 5, Toyosato-machi, Tsukuba-gun, Ibaragi, Japan
&
T. Fujita Tsukuba Research Laboratories, Eisai Co. Ltd, Tokodai 5, Toyosato-machi, Tsukuba-gun, Ibaragi, Japan
Pages 549-559 | Received 22 Mar 1982, Published online: 22 Sep 2008

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G. Schmitz, K. O. Stumpe, W. Herrmann & G. Weidinger. (1996) Effects of Bunazosin and Atenolol on Serum Lipids and Apolipoproteins in a Randomised Trial. Blood Pressure 5:6, pages 354-359.
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A. L. Servin, D. Wicek, M. P. Oryszczyn, C. Jacquot, J. P. Lussiana, H. Christinaki & C. Viel. (1987) Metabolism of 6,7-dimethoxy 4-(4′-chlorobenzyl)isoquinoline. II. Role of liver catechol O-methyltransferase and glutathione. Xenobiotica 17:12, pages 1381-1391.
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A. L. Servin, C. Jacquot, J. P. Lussiana & C. Viel. (1985) Metabolism of 6,7-dimethoxy 4-(p-chlorobenzyl)-isoquinoline. I. Single-dose pharmacokinetics in the rat and mouse. Xenobiotica 15:7, pages 553-566.
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Articles from other publishers (6)

Takahiro Shibayama, Yoko Matsushita, Kenji Kawai, Takashi Hirota, Toshihiko Ikeda & Shogo Kuwahara. (2007) Pharmacokinetics and Disposition of CS-023 (RO4908463), a Novel Parenteral Carbapenem, in Animals. Antimicrobial Agents and Chemotherapy 51:1, pages 257-263.
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Fatih M. Uckun, Jason Thoen, Hao Chen, Elise Sudbeck, Chen Mao, Ravi Malaviya, Xing-Ping Liu & Chun-Lin Chen. (2002) CYP1A-Mediated Metabolism of the Janus Kinase-3 Inhibitor 4-(4′-Hydroxyphenyl)-amino-6,7-dimethoxyquinazoline: Structural Basis for Inactivation by Regioselective O -Demethylation . Drug Metabolism and Disposition 30:1, pages 74-85.
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Axel Mescheder, Atef Halabi, Ali Nokhodian, Yousif Al-Hamdan & Wilhelm Kirch. (2012) Antihypertensive Activity, Cardiac Performance and Pharmacokinetics of Bunazosin, a Novel α1-Adrenoceptor Antagonist, in Patients with Normal and Impaired Renal Function. Drug Investigation 6:5, pages 263-270.
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A. Halabi, A. Nokhodian & W. Kirch. (1993) Bunazosin in patients with impaired hepatic or renal function. European Journal of Drug Metabolism and Pharmacokinetics 18:3, pages 309-313.
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Matao Sakanashi. (2007) Bunazosin. Cardiovascular Drug Reviews 6:2, pages 155-165.
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G.L. LARSEN. 1988. Role of the Gut Flora in Toxicity and Cancer. Role of the Gut Flora in Toxicity and Cancer 79 107 .

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