Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 12, 1982 - Issue 11
31
Views
133
CrossRef citations to date
0
Altmetric
Original Article

Purification and characterization of microsomal cytochrome P-450s

, , , &
Pages 701-716 | Received 30 Jun 1982, Published online: 30 Sep 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (24)

Manika Varshney, Vinod Vijayan & Ghansham P. Meshram. (2015) Chemopreventive effects of ellagic acid against genotoxicity induced by benzo(a)pyrene. Toxicological & Environmental Chemistry 97:6, pages 786-798.
Read now
J. M. Haake-McMillan & S. H. Safe. (1991) Neonatal exposure to Aroclor 1254: Effects on adult hepatic testosterone hydroxylase activities. Xenobiotica 21:4, pages 481-489.
Read now
Leendert van Bree, Paul G. J. Reuzel, Marian A. Verhoef, Jan Bos & Peter J. A. Rombout. (1990) Effects of Acute Inhalation of Respirable Coal Fly Ash on Metabolic Defense Capability of the Rat Lung. Inhalation Toxicology 2:4, pages 361-373.
Read now
John Kao & Michael P. Carver. (1990) Cutaneous Metabolism of Xenobiotics. Drug Metabolism Reviews 22:4, pages 363-410.
Read now
I. B. Tsyrlov & T. G. Duzchak. (1990) Interspecies features of hepatic cytochromes P450 IA1 and P450 IA2 in rodents. Xenobiotica 20:11, pages 1163-1170.
Read now
K. Wu, C. L. Leslie & N. H. Stacey. (1989) Effects of mutagenic and non-mutagenic aniline derivatives on rat liver drug-metabolizing enzymes. Xenobiotica 19:11, pages 1275-1283.
Read now
I. M. C. M. Rietjens, J. A. M. A. Dormans, P. J. A. Rombout & L. van Bree. (1988) Qualitative and quantitative changes in cytochrome p‐450‐dependent xenobiotic metabolism in pulmonary microsomes and isolated clara cell populations derived from ozone‐exposed rats. Journal of Toxicology and Environmental Health 24:4, pages 515-531.
Read now
W. P. Ridley, J. Warren & R. S. Nair. (1988) Effect of tetrachlorophthalic anhydride on hepatic microsomal metabolism in rats and mice. Journal of Toxicology and Environmental Health 24:2, pages 217-227.
Read now
M. Van Der Graaff, N. P. E. Vermeulen & D. D. Breimer. (1988) Disposition of hexobarbital: 15 years of an intriguing model substrate. Drug Metabolism Reviews 19:2, pages 109-164.
Read now
G. F. Reidy, H. A. Rose & N. H. Stacey. (1987) Effects of picloram on xenobiotic biotransformation in rat liver. Xenobiotica 17:9, pages 1057-1066.
Read now
A. R. Boobis, C. Whyte & D. S. Davies. (1986) Selective induction and inhibition of the components of 7-ethoxycoumarin O-deethylase activity in the rat. Xenobiotica 16:3, pages 233-238.
Read now
M. Van Der Graaff, N. P. E. Vermeulen, P. Heij, H. De Bree & D. D. Breimer. (1986) Correlation between the metabolism of hexobarbital and aminopyrine in vivo in rats. Xenobiotica 16:12, pages 1091-1096.
Read now
F. Peter Guengerich, Daniel C. Liebler & Donald L. Reed. (1985) Enzymatic activation of chemicals to toxic metabolites. CRC Critical Reviews in Toxicology 14:3, pages 259-307.
Read now
Stephen Safe & Otto Hutzinger. (1984) Polychlorinated Biphenyls (PCBs) and Polybrominated Biphenyls (PBBs): Biochemistry, Toxicology, and Mechanism of Action. CRC Critical Reviews in Toxicology 13:4, pages 319-395.
Read now
Pauline Paterson, J. R. Fry & S. A. Horner. (1984) Influence of cytochrome P-450 type on the pattern of conjugation of 7-hydroxycoumarin generated from 7-alkoxycoumarins. Xenobiotica 14:11, pages 849-859.
Read now
A. R. Boobis & D. S. Davies. (1984) Human cytochromes P-450. Xenobiotica 14:1-2, pages 151-185.
Read now
C. Ioannides, P. Y. Lum & D. V. Parke. (1984) Cytochrome P-448 and the activation of toxic chemicals and carcinogens. Xenobiotica 14:1-2, pages 119-137.
Read now

Articles from other publishers (109)

John P. Rooney, Natalia Ryan, Brian N. Chorley, Susan D. Hester, Elaina M. Kenyon, Judith E. Schmid, Barbara Jane George, Michael F. Hughes, Yusupha M. Sey, Alan Tennant, Denise K. MacMillan, Jane Ellen Simmons, Charlene A. McQueen, Arun Pandiri, Charles E. Wood & J. Christopher Corton. (2017) From the Cover: Genomic Effects of Androstenedione and Sex-Specific Liver Cancer Susceptibility in Mice. Toxicological Sciences 160:1, pages 15-29.
Crossref
April D. Lake, Charles E. Wood, Virunya S. Bhat, Brian N. Chorley, Gleta K. Carswell, Yusupha M. Sey, Elaina M. Kenyon, Beth Padnos, Tanya M. Moore, Alan H. Tennant, Judith E. Schmid, Barbara Jane George, David G. Ross, Michael F. Hughes, J. Christopher Corton, Jane Ellen Simmons, Charlene A. McQueen & Susan D. Hester. (2016) Dose and Effect Thresholds for Early Key Events in a PPARα-Mediated Mode of Action. Toxicological Sciences 149:2, pages 312-325.
Crossref
Seema Bansal, Hindupur K. Anandatheerthavarada, Govindaswamy K. Prabu, Ginger L. Milne, Martha V. Martin, F.Peter Guengerich & Narayan G. Avadhani. (2013) Human Cytochrome P450 2E1 Mutations That Alter Mitochondrial Targeting Efficiency and Susceptibility to Ethanol-induced Toxicity in Cellular Models. Journal of Biological Chemistry 288:18, pages 12627-12644.
Crossref
C A Joseph & P A F Dixon. (1984) A possible cytochrome P-450-mediated N -oxidation of diethylcarbamazine . Journal of Pharmacy and Pharmacology 36:10, pages 711-712.
Crossref
Jeroen Kool, Sebastiaan M. van Liempd, Huub van Rossum, Danny A. van Elswijk, Hubertus Irth, Jan N. M. Commandeur & Nico P. E. Vermeulen. (2007) Development of Three Parallel Cytochrome P450 Enzyme Affinity Detection Systems Coupled On-line to Gradient High-Performance Liquid Chromatography. Drug Metabolism and Disposition 35:4, pages 640-648.
Crossref
Kang-Hun Cho & Sun-Mee Lee. (2007) Altered activity of cytochrome P450 in alcoholic fatty liver exposed to ischemia/reperfusion. Archives of Pharmacal Research 30:1, pages 50-57.
Crossref
Hyun-Ae Eum, Dong-Ho Yeom & Sun-Mee Lee. (2006) Role of nitric oxide in the inhibition of liver cytochrome P450 during sepsis. Nitric Oxide 15:4, pages 423-431.
Crossref
Sang-Ho Lee & Sun-Mee Lee. (2005) SUPPRESSION OF HEPATIC CYTOCHROME P450-MEDIATED DRUG METABOLISM DURING THE LATE STAGE OF SEPSIS IN RATS. Shock 23:2, pages 144-149.
Crossref
Hyun-Ae Eum & Sun-Mee Lee. (2004) Effects of Trolox on the activity and gene expression of cytochrome P 450 in hepatic ischemia/reperfusion . British Journal of Pharmacology 142:1, pages 35-42.
Crossref
Woon-Gye Chung & Donald R. Buhler. (2004) Differential metabolism of the pyrrolizidine alkaloid, senecionine, in fischer 344 and sprague-dawley Rats. Archives of Pharmacal Research 27:5, pages 547-553.
Crossref
Sang-Won Park & Sun-Mee Lee. (2004) The beneficial effect of trolox on sepsis-induced hepatic drug metabolizing dysfunction. Archives of Pharmacal Research 27:2, pages 232-238.
Crossref
Nadezhda Galeva & Michail Altermann. (2002) Comparison of one-dimensional and two-dimensional gel electrophoresis as a separation tool for proteomic analysis of rat liver microsomes: Cytochromes P450 and other membrane proteins. PROTEOMICS 2:6, pages 713-722.
Crossref
Michail A. Alterman & Robert P. Hanzlik. (2002) Hydroxylation of fatty acids by microsomal and reconstituted cytochrome P450 2B1. FEBS Letters 512:1-3, pages 319-322.
Crossref
Tomas Cvrk & Henry W. Strobel. (2001) Role of LYS271 and LYS279 Residues in the Interaction of Cytochrome P4501A1 with NADPH?Cytochrome P450 Reductase. Archives of Biochemistry and Biophysics 385:2, pages 290-300.
Crossref
Lilly Xu, Albert P Li, Donald L Kaminski & Mary F Ruh. (2000) 2,3,7,8 Tetrachlorodibenzo-p-dioxin induction of cytochrome P4501A in cultured rat and human hepatocytes. Chemico-Biological Interactions 124:3, pages 173-189.
Crossref
K.M.L. Crommentuyn, J.H.M. Schellens, J.D. van den Berg & J.H. Beijnen. (1998) In-vitro metabolism of anti-cancer drugs, methods and applications: paclitaxel, docetaxel, tamoxifen and ifosfamide. Cancer Treatment Reviews 24:5, pages 345-366.
Crossref
Chul-Ho Yun, Taeho Ahn & F.Peter Guengerich. (1998) Conformational Change and Activation of Cytochrome P450 2B1 Induced by Salt and Phospholipid. Archives of Biochemistry and Biophysics 356:2, pages 229-238.
Crossref
T.D Goloubkova, E Heckler, S.M.K Rates, J.A.P Henriques & A.T Henriques. (1998) Inhibition of cytochrome P450-dependent monooxygenases by an alkaloid fraction from Helietta apiculata markedly potentiate the hypnotic action of pentobarbital. Journal of Ethnopharmacology 60:2, pages 141-148.
Crossref
Wei Zhao & Kenneth S. Ramos. (1995) Inhibition of DNA synthesis in primary cultures of adult rat hepatocytes by benzo[a]pyrene and related aromatic hydrocarbons: Role of Ah receptor-dependent events. Toxicology 99:3, pages 179-189.
Crossref
A. A. Bakibaev, T. P. Novozheeva, R. R. Akhmedzhanov & A. S. Saratikov. (1995) Inducers of the phenobarbital type (a review). Pharmaceutical Chemistry Journal 29:3, pages 153-164.
Crossref
W. Klinger, E. Karge, M. Danz & M. Krug. (1995) Nerval influences on liver cytochrome P450. Experimental and Toxicologic Pathology 47:4, pages 299-303.
Crossref
Andreas Langner. (2006) Ersatz‐ und Ergänzungsmethoden zur Untersuchung der Biotransformation von Arzneistoffen. Pharmazie in unserer Zeit 24:4, pages 207-218.
Crossref
Chukwuemeka S. Okereke, Mohamed S. Abdel-Rhaman & Marvin A. Friedman. (1994) Disposition of benzophenone-3 after dermal administration in male rats. Toxicology Letters 73:2, pages 113-122.
Crossref
J.J.R. Hermans & H.H.W. Thijssen. (1993) Human liver microsomal metabolism of the enantiomers of warfarin and acenocoumarol: P450 isozyme diversity determines the differences in their pharmacokinetics. British Journal of Pharmacology 110:1, pages 482-490.
Crossref
Joseph G. ShaddockJr.Jr., R. J. Feuers & D. A. Casciano. (1993) Aging and enzyme induction: Effect on chemically-induced DNA repair in non-proliferating Fischer F344 rat hepatocytes. AGE 16:3.
Crossref
J.G. Shaddock, R.J. Feuers, M.W. Chou & D.A. Casciano. (1993) Evidence that DNA repair may not be modified by age or chronic caloric restriction. Mutation Research Letters 301:4, pages 261-266.
Crossref
Silvia Menicagli, Annalisa Lippi, Marco Criscuoli & Pier Giovanni Gervasi. (1993) Effect of rociverine on P450-dependent monooxygenases and its N-deethylation metabolism in rat liver microsomes. Biochemical Pharmacology 45:5, pages 1097-1105.
Crossref
J.G. Shaddock, R.J. Feuers, M.W. Chou, R.A. Pegram & D.A. Casciano. (1993) Effects of aging and caloric restriction on the genotoxicity of four carcinogens in the in vitro rat hepatocyte/DNA repair assay. Mutation Research/DNAging 295:1, pages 19-30.
Crossref
J. G. Shaddock, J. E. Snawder & D. A. Casciano. (1993) Cryopreservation and long-term storage of primary rat hepatocytes: Effects on substrate-specific cytochrome P450-dependent activities and unscheduled DNA synthesis. Cell Biology and Toxicology 9:4, pages 345-357.
Crossref
Wim E.M. Mol, Michael M?ller, Gerhart Kurz & Dirk K.F. Meijer. (1992) Investigations on the hepatic uptake systems for organic cations with a photoaffinity probe of procainamide ethobromide. Biochemical Pharmacology 43:10, pages 2217-2226.
Crossref
A.D. Ayrton, D.F.V. Lewis, R. Walker & C. Ioannides. (1992) Antimutagenicity of ellagic acid towards the food mutagen IQ: Investigation into possible mechanisms of action. Food and Chemical Toxicology 30:4, pages 289-295.
Crossref
Christopher R. Barnett, Rebecca A. Abbott, Clifford J. Bailey, Peter R. Flatt & Costas Ioannides. (1992) Cytochrome P450-dependent mixed-function oxidase and glutathione S-transferase activities in spontaneous obesity-diabetes. Biochemical Pharmacology 43:8, pages 1868-1871.
Crossref
Christopher R. Barnett, Judith Wilson, C.Roland Wolf, Peter R. Flatt & Costas Ioannides. (1992) Hyperinsulinaemia causes a preferential increase in hepatic p4501A2 activity. Biochemical Pharmacology 43:6, pages 1255-1261.
Crossref
Sun-Mee Lee & Mark G. Clemens. (1992) Effect of α-tocopherol on hepatic mixed function oxidases in hepatic ischemia/reperfusion. Hepatology 15:2, pages 276-281.
Crossref
Delmont C. Eberhart & Andrew Parkinson. (1991) Cytochrome P450 IIIA1 (P450p) requires cytochrome b5 and phospholipid with unsaturated fatty acids. Archives of Biochemistry and Biophysics 291:2, pages 231-240.
Crossref
I. B. Tsyrlov & K. E. Gerasimov. (1991) Aminopyrine-N-demethylase. II. Characterization of a unique monooxygenase isoform P-450ap. European Journal of Drug Metabolism and Pharmacokinetics 16:3, pages 213-217.
Crossref
Andrew D. Ayrton, Costas Ioannides & Dennis V. Parke. (1991) Induction of the cytochrome P450 I and IV families and peroxisomal proliferation in the liver of rats treated with benoxaprofen. Biochemical Pharmacology 42:1, pages 109-115.
Crossref
Hans-Ulrich Aeschbacher & Robert J. Turesky. (1991) Mammalian cell mutagenicity and metabolism of heterocyclic aromatic amines. Mutation Research/Genetic Toxicology 259:3-4, pages 235-250.
Crossref
W. Klinger, D. M?ller, U. Kleeberg, M. Kretzschmar & F.-K. Splinter. (1991) The influence of ?essential? phospholipids (EPL) on phase-I- and phase-II-reactions and on the glutathione status in the liver of aging rats. Experimental pathology 41:3, pages 151-156.
Crossref
Michael A. Alterman & Andrew I. Dowgii. (1990) A simple and rapid method for the purification of cytochrome P-450 (form LM4). Biomedical Chromatography 4:5, pages 221-222.
Crossref
Thomas Friedberg, Markus A. Grassow & Franz Oesch. (1990) Selective detection of mRNA forms encoding the major phenobarbital inducible cytochromes P450 and other members of the P450IIB family by the RNAse A protection assay. Archives of Biochemistry and Biophysics 279:1, pages 167-173.
Crossref
Jonathan N. Smith, Andrew D. Ayrton, Janice Chown, David F. V. Lewis & Costas Ioannides. (2006) Feprazone: An inducer of the P450 II B family of proteins in the rat. Journal of Biochemical Toxicology 5:1, pages 9-12.
Crossref
D.V. Parke, C. Ioannides & D.F.V. Lewis. (1990) Computer modelling and in vitro tests in the safety evaluation of chemicals—Strategic applications. Toxicology in Vitro 4:4-5, pages 680-685.
Crossref
A.D. Ayrton, M. McFarlane, R. Walker, S. Neville, M.M. Coombs & C. Ioannides. (1990) Induction of the P-450 I family of proteins by polycyclic aromatic hydrocarbons: possible relationship to their carcinogenicity. Toxicology 60:1-2, pages 173-186.
Crossref
Dirk K. F. Meijer. 2011. Comprehensive Physiology. Comprehensive Physiology 717 758 .
Catherine Leslie, Gordon F. Reidy & Neill H. Stacey. (1989) Effect of ofurace, oxadixyl, and alachlor on xenobiotic biotransformation in the rat liver. Archives of Environmental Contamination and Toxicology 18:6, pages 876-880.
Crossref
Rass M. Shayiq & Narayan G. Avadhani. (2002) Purification and characterization of a hepatic mitochondrial cytochrome P-450 active in aflatoxin B1 metabolism. Biochemistry 28:19, pages 7546-7554.
Crossref
A. David RODRIGUES, Andrew D. AYRTON, Elisabeth J. WILLIAMS, David F. V. LEWIS, Ronald WALKER & Costas IOANNIDES. (2005) Preferential induction of the rat hepatic P 450 I proteins by the food carcinogen 2‐amino‐3‐methyl‐imidazo[4,5‐ f ]quinoline . European Journal of Biochemistry 181:3, pages 627-631.
Crossref
Matti A. Lang, Risto Juvonen, Päivi Järvinen, Paavo Honkakoski & Hannu Raunio. (1989) Mouse liver P450Coh: Genetic regulation of the pyrazole-inducible enzyme and comparison with other P450 isoenzymes. Archives of Biochemistry and Biophysics 271:1, pages 139-148.
Crossref
Franz Oesch, David J. Waxman, Joseph J. Morrissey, Walther Honscha, Wolfgang Kissel & Thomas Friedberg. (1989) Antibodies targeted against hypervariable and constant regions of cytochromes P450IIB1 and P450IIB2. Archives of Biochemistry and Biophysics 270:1, pages 23-32.
Crossref
David R. Dutton & Andrew Parkinson. (1989) Reduction of 7-alkoxyresorufins by NADPH-cytochrome P450 reductase and its differential effects on their O-dealkylation by rat liver microsomal cytochrome P450. Archives of Biochemistry and Biophysics 268:2, pages 617-629.
Crossref
David R. Dutton, Gregory A. Reed & Andrew Parkinson. (1989) Redox cycling of resorufin catalyzed by rat liver microsomal NADPH-cytochrome P450 reductase. Archives of Biochemistry and Biophysics 268:2, pages 605-616.
Crossref
Beate Seibert, Franz Oesch & Pablo Steinberg. (1989) Distribution and induction of cytochrome P-450 and two cytochrome P-450-dependent monooxygenase activities in rat liver parenchymal cell subpopulations separated by centrifugal elutriation. Archives of Toxicology 63:1, pages 18-22.
Crossref
U. Schoknecht & D. Otto. 1989. Degradation of Pesticides, Desiccation and Defoliation, ACh-Receptors as Targets. Degradation of Pesticides, Desiccation and Defoliation, ACh-Receptors as Targets 117 156 .
Andrew D. Ayrton, Julia Trinick, Beverley P. Wood, Jonathan N. Smith & Costas Ioannides. (1988) Induction of the rat hepatic microsomal mixed-function oxidases by two aza-arenes. Biochemical Pharmacology 37:23, pages 4565-4571.
Crossref
Paavo Honkakoski, Seija Autio, Risto Juvonen, Hannu Raunio, Harry V. Gelboin, Sang Shin Park, Olavi Pelkonen & Matti A. Lang. (1988) Pyrazole is different from acetone and ethanol as an inducer of the polysubstrate monooxygenase system in mice: Evidence that pyrazole-inducible P450Coh is distinct from acetone-lnducible P450ac. Archives of Biochemistry and Biophysics 267:2, pages 589-598.
Crossref
J. M. Haake & S. H. Safe. (2006) Neonatal phenobarbital imprinting of rat hepatic microsomal testosterone hydroxylations. Journal of Biochemical Toxicology 3:4, pages 309-319.
Crossref
Christopher R. Barnett, Peter R. Flatt & Costas Ioannides. (1988) Role of ketone bodies in the diabetes-induced changes in hepatic mixed-function oxidase activities. Biochimica et Biophysica Acta (BBA) - General Subjects 967:2, pages 250-254.
Crossref
C. Leslie, G.F. Reidy & N.H. Stacey. (1988) The effects of propiconazole on hepatic xenobiotic biotransformation in the rat. Biochemical Pharmacology 37:21, pages 4177-4181.
Crossref
Mikael Gillner. (1988) Polyacrylamide concentration gradient gel electrophoresis of the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) receptor in rat liver cytosol. Toxicology Letters 42:3, pages 273-284.
Crossref
Andrew J. Sonderfan & Andrew Parkinson. (1988) Inhibition of steroid 5?-reductase and its effects on testosterone hydroxylation by rat liver microsomal cytochrome P-450. Archives of Biochemistry and Biophysics 265:1, pages 208-218.
Crossref
J. MOUNIÉ, L. CHAMPION, H. GOUDONNET, A. ESCOUSSE & R.C. TRUCHOT. (1988) INDUCTIVE EFFECTS OF FENOFIBRATE AND METABOLISM OF PHENOBARBITAL. Fundamental & Clinical Pharmacology 2:4, pages 259-265.
Crossref
Catherine Leslie, Gordon F. Reidy, Michael Murray & Neill H. Stacey. (1988) Induction of xenobiotic biotransformation by the insecticide chlordimeform, a metabolite 4-chloro-o-toluidine and a structurally related chemical o-toluidine. Biochemical Pharmacology 37:13, pages 2529-2535.
Crossref
Jeffrey Baron, Jon P. Burke, F.Peter Guengerich, William B. Jakoby & Jeffrey M. Voigt. (1988) Sites for xenobiotic activation and detoxication within the respiratory tract: Implications for chemically induced toxicity. Toxicology and Applied Pharmacology 93:3, pages 493-505.
Crossref
John O. Miners, Kerry J. Smith, Richard A. Robson, Michael E. McManus, Maurice E. Veronese & Donald J. Birkett. (1988) Tolbutamide hydroxylation by human liver microsomes. Biochemical Pharmacology 37:6, pages 1137-1144.
Crossref
G.F. Reidy, M. Murray, H.A. Rose, A.M. Bonin, R.S.U. Baker & N.H. Stackey. (1988) Identification of the hepatic cytochrome P-450 isozymes induced and decreased by picloram. Biochemical Pharmacology 37:6, pages 1021-1025.
Crossref
Erin G. Schuetz, Donna Li, Curtis J. Omiecinski, Ursula Muller-Eberhard, Hynda K. Kleinman, Barbara Elswick & Philip S. Guzelian. (1988) Regulation of gene expression in adult rat hepatocytes cultured on a basement membrane matrix. Journal of Cellular Physiology 134:3, pages 309-323.
Crossref
J.Brian Houston, Michael J. Humphrey, Diana E. Matthew & Michael H. Tarbit. (1988) Comparison of two azole antifungal drugs, ketoconazole and fluconazole, as modifiers of rat hepatic monooxygenase activity. Biochemical Pharmacology 37:3, pages 401-408.
Crossref
W. Klinger, T. Devereux & J. Fouts. (1988) Separation and characterization of hepatocytes from immature and adult rats into distinct subpopulations by centrifugal elutriation. Experimental pathology 33:4, pages 213-222.
Crossref
C. Brouard, M.H. Siess, M.F. Vernevaut & M. Suschetet. (1988) Comparison of the effects of feeding quercetin or flavone on hepatic and intestinal drug-metabolizing enzymes of the rat. Food and Chemical Toxicology 26:2, pages 99-103.
Crossref
A.D. Ayrton, C. Ioannides & R. Walker. (1988) Induction of rat hepatic cytochrome P-450 I proteins by the antimutagen anthraflavic acid. Food and Chemical Toxicology 26:11-12, pages 909-915.
Crossref
M.H. Siess, M.F. Vernevaut, A. Grandgirard & J.L. S?b?dio. (1988) Induction of hepatic drug-metabolizing enzymes by cyclic fatty acid monomers in the rat. Food and Chemical Toxicology 26:1, pages 9-13.
Crossref
Pablo Steinberg, Beate Seibert & Franz Oesch. 1988. Experimental Hepatocarcinogenesis. Experimental Hepatocarcinogenesis 257 265 .
David R. Dutton, Susan K. McMillen & Andrew Parkinson. (1988) Purification of rat liver microsomal cytochrome P-450b without the use of nonionic detergent. Journal of Biochemical Toxicology 3:2, pages 131-145.
Crossref
Yoshihiko Funae & Susumu Imaoka. (1987) Purification and characterization of liver microsomal cytochrome P-450 from untreated male rats. Biochimica et Biophysica Acta (BBA) - General Subjects 926:3, pages 349-358.
Crossref
Andrew D. Ayrton, David F.V. Lewis, Costas Ioannides & Ronald Walker. (1987) Anthraflavic acid is a potent and specific inhibitor of cytochrome P-448 activity. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 916:3, pages 328-331.
Crossref
Costas Ioannides & Dennis V. Parke. (1987) The cytochromes P-448—A unique family of enzymes involved in chemical toxicity and carcinogenesis. Biochemical Pharmacology 36:24, pages 4197-4207.
Crossref
G.F. Reidy, H.A. Rose & N.H. Stacey. (1987) Evidence for cytochrome P-450 multiplicity in the midgut of the cluster caterpillar, Spodoptera litura (F.). Pesticide Biochemistry and Physiology 29:2, pages 176-186.
Crossref
G. I. Murray, T. S. Barnes, H. F. Sewell, S. W. B. Ewen, W. T. Melvin, P. M. Shaw, J. Fowler & M. D. Burke. (1987) Cytochrome P-450 localization in normal human adult and foetal liver by immunocytochemistry using a monoclonal antibody against human cytochrome P—450. The Histochemical Journal 19:10-11, pages 537-545.
Crossref
Nancy A. Lorr & Stephen E. Bloom. (1987) Ontogeny of the chicken cytochrome P-450 enzyme system. Biochemical Pharmacology 36:18, pages 3059-3067.
Crossref
D.R. Dutton, S.K. McMillen, A.J. Sonderfan, P.E. Thomas & A. Parkinson. (1987) Studies on the rate-determining factor in testosterone hydroxylation by rat liver microsomal cytochrome P-450: Evidence against cytochrome P-450 isozyme:Isozyme interactions. Archives of Biochemistry and Biophysics 255:2, pages 316-328.
Crossref
Gaut Gadeholt. (1987) Spectral Interaction between 4-Methylphenol and β-Oestradiol on Hepatic Microsomal Cytochrome P-450: Difference between Ethanol and Phenobarbital Pretreatment. Pharmacology & Toxicology 60:5, pages 399-400.
Crossref
Andrew J. Sonderfan, Michael P. Arlotto, David R. Dutton, Susan K. McMillen & Andrew Parkinson. (1987) Regulation of testosterone hydroxylation by rat liver microsomal cytochrome P-450. Archives of Biochemistry and Biophysics 255:1, pages 27-41.
Crossref
Dennis V. Parke. (1987) Activation mechanisms to chemical toxicity. Archives of Toxicology 60:1-3, pages 5-15.
Crossref
Mitsukazu Kitada, Tetsuya Kamataki, Koshiro Itahashi, Tadaaki Rikihisa & Yoshio Kanakubo. (1987) Significance of cytochrome P-450 (P-450 HFLa) of human fetal livers in the steroid and drug oxidations. Biochemical Pharmacology 36:4, pages 453-456.
Crossref
A. Parkinson & S. Safe. 1987. Polychlorinated Biphenyls (PCBs): Mammalian and Environmental Toxicology. Polychlorinated Biphenyls (PCBs): Mammalian and Environmental Toxicology 49 75 .
Craig B. Marcus, Michael Murray, Cheng Wang & Christopher F. Wilkinson. (1986) Methylenedioxyphenyl compounds as inducers of cytochrome P-450 and monooxygenase activity in the southern armyworm (Spodoptera eridania) and the rat. Pesticide Biochemistry and Physiology 26:3, pages 310-322.
Crossref
D. Sanglard, O. K?ppeli & A. Fiechter. (1986) The distinction of different types of cytochromes P-450 from the yeasts Candida tropicalis and Saccharomyces uvarum. Archives of Biochemistry and Biophysics 251:1, pages 276-286.
Crossref
P.Y. Lum, M.D. Burke, R.T. Mayer & C. Ioannides. (1986) Alkoxyresorufin O-dealkylases: Association with the murine Ah locus. Cancer Letters 32:3, pages 255-262.
Crossref
M. Van der Graaff, N.P.E. Vermeulen, P.H. Hofman & D.D. Breimer. (1986) The influence of pretreatment on the urinary metabolite profile of pseudoracemic hexobarbital. Biochemical Pharmacology 35:18, pages 3166-3169.
Crossref
N. I. Gutkina & V. M. Mishin. (1986) Monospecificity of antibodies against different forms of cytochrome B-450 studied by rocket immunoelectrophoresis. Bulletin of Experimental Biology and Medicine 102:1, pages 908-910.
Crossref
Michael Murray, Louise Zaluzny & Geoffrey C. Farrell. (1986) Drug metabolism in cirrhosis. Biochemical Pharmacology 35:11, pages 1817-1824.
Crossref
W. Klinger, T. Devereux, R. Maronpot & J. Fouts. (1986) Functional hepatocellular heterogeneity determined by the hepatotoxins allyl alcohol and bromobenzene in immature and adult Fischer 344 rats. Toxicology and Applied Pharmacology 83:1, pages 108-114.
Crossref
Arfaan Rampersaud & Frederick G. WalzJr.Jr.. (1986) Cytochrome P-450 polypeptides in pulmonary microsomes from rats. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 869:3, pages 293-303.
Crossref
T Shimada, K S Misono & F P Guengerich. (1986) Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction.. Journal of Biological Chemistry 261:2, pages 909-921.
Crossref
Costas Ioannides & Christine M. Steele. (1986) Hepatic microsomal mixed-function oxidase activity in ethanol-treated hamsters and its consequences on the bioactivation of aromatic amines to mutagens. Chemico-Biological Interactions 59, pages 129-139.
Crossref
Lyudmila F. Gulyaeva, Vladimir M. Mishin & Vyacheslav V. Lyakhovich. (1986) Induction and catalytic activities of cytochromes P-450b/e and P-450c in the liver microsomes of neonatal rats. International Journal of Biochemistry 18:9, pages 829-834.
Crossref
Jeffrey Baron, Jeffrey M. Voigt, Tyrone B. Whitter, Thomas T. Kawabata, Shirley A. Knapp, F. Peter Guengerich & William B. Jakoby. 1986. Biological Reactive Intermediates III. Biological Reactive Intermediates III 119 144 .
Craig B. Marcus, Christopher Turner & Colin R. Jefcoate. (2002) Binding of benzo[a]pyrene by purified cytochrome P-450c. Biochemistry 24:19, pages 5115-5123.
Crossref
M.Danny Burke, Stephanie Thompson, Clifford R. Elcombe, James Halpert, Tapio Haaparanta & Richard T. Mayer. (1985) Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450. Biochemical Pharmacology 34:18, pages 3337-3345.
Crossref
J R Halpert, N E Miller & L D Gorsky. (1985) On the mechanism of the inactivation of the major phenobarbital-inducible isozyme of rat liver cytochrome P-450 by chloramphenicol.. Journal of Biological Chemistry 260:14, pages 8397-8403.
Crossref
Laurence S. KAMINSKY & F. Peter GUENGERICH. (1985) Cytochrome P-450 isozyme/isozyme functional interactions and NADPH-cytochrome P-450 reductase concentrations as factors in microsomal metabolism of warfarin. European Journal of Biochemistry 149:3, pages 479-489.
Crossref
Stephen Safe, Stelvio Bandiera, Tom Sawyer, Larry Robertson, Lorna Safe, Andrew Parkinson, Paul E. Thomas, Dene E. Ryan, Linda M. Reik, Wayne Levin, Mary Anne Denomme & Toshio Fujita. (1985) PCBs: structure–function relationships and mechanism of action. Environmental Health Perspectives 60, pages 47-56.
Crossref
Hakan Wallin, Per Melin, Cecilia Schelin & Bengt Jergil. (1985) Evidence that covalent binding of metabolically activated phenol to microsomal proteins is caused by oxidised products of hydroquinone and catechol. Chemico-Biological Interactions 55, pages 335-346.
Crossref
P.A.F. Dixon, S.E. Okereke & M.C.N. Enwelum. (1985) Influence of species, sex and drug pretreatment on the metabolism of metyrapone. Comparative Biochemistry and Physiology Part C: Comparative Pharmacology 81:1, pages 241-243.
Crossref
Caroline E. Phillipson, Costas Ioannides, David C.A. Barrett & Dennis V. Parke. (1985) The homogeneity of rat liver microsomal cytochrome P-448 activity and its role in the activation of benzo[a]pyrene to mutagens. International Journal of Biochemistry 17:1, pages 37-42.
Crossref
M. Ira Thabrew & Costas Ioannides. (1984) Inhibition of rat hepatic mixed function oxidases by antimalarial drugs: Selectivity for cytochromes P-450 and P-448. Chemico-Biological Interactions 51:3, pages 285-294.
Crossref
Barbara L. Harper, V.M.Sadagopa Ramanujam, Mohy M. Gad-El-Karim & Marvin S. Legator. (1984) The influence of simple aromatics on benzene clastogenicity. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 128:2, pages 105-114.
Crossref
G T Miwa, J S Walsh & A Y Lu. (1984) Kinetic isotope effects on cytochrome P-450-catalyzed oxidation reactions. The oxidative O-dealkylation of 7-ethoxycoumarin.. Journal of Biological Chemistry 259:5, pages 3000-3004.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.