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Xenobiotica
the fate of foreign compounds in biological systems
Volume 12, 1982 - Issue 11
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Original Article

Cytochrome P-450 rotamers control mixed-function oxygenation in reconstituted membranes. Rotational diffusion studied by delayed fluorescence depolarizationd`

R. Greinert Max-Planck-Institut für Biophysikalische Chemie, Göttingen, FR Germany
,
S. A. E. Finch Max-Planck-Institut für Biophysikalische Chemie, Göttingen, FR Germany
&
A. Stier Max-Planck-Institut für Biophysikalische Chemie, Göttingen, FR Germany
Pages 717-726 | Received 30 Jun 1982, Published online: 30 Sep 2009

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Dmitri R Davydov. (2011) Microsomal monooxygenase as a multienzyme system: the role of P450-P450 interactions. Expert Opinion on Drug Metabolism & Toxicology 7:5, pages 543-558.
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Dmitri R Davydov & James R Halpert. (2008) Allosteric P450 mechanisms: multiple binding sites, multiple conformers or both?. Expert Opinion on Drug Metabolism & Toxicology 4:12, pages 1523-1535.
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Peter Hlavica. (1994) Regulatory Mechanisms in the Activation of Nitrogenous Compounds by Mammalian Cytochrome P-450 Isozymes. Drug Metabolism Reviews 26:1-2, pages 325-348.
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C. Ioannides & D. V. Parke. (1990) The Cytochrome P450 I Gene Family of Microsomal Hemoproteins and Their Role in the Metabolic Activation of Chemicals. Drug Metabolism Reviews 22:1, pages 1-85.
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J. Blanck, G. R. Jänig, D. Schwarz & K. Ruckpaul. (1989) Role of lipid in the electron transfer between NADPH-cytochrome P-450 reductase and cytochrome P-450 from mammalian liver cells. Xenobiotica 19:11, pages 1231-1246.
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Bryan R. Hollebone. (1986) Categorization of Lipophilic Xenobiotics by the Enthalpic Structure-Function Response of Hepatic Mixed-Function Oxidase. Drug Metabolism Reviews 17:1-2, pages 93-143.
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David F. V. Lewis. (1986) Physical Methods in the Study of the Active Site Geometry of Cytochromes P-450. Drug Metabolism Reviews 17:1-2, pages 1-66.
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Articles from other publishers (34)

Karin Nienhaus, Vandna Sharma, Gerd Ulrich Nienhaus & Larissa M. Podust. (2022) Homodimerization Counteracts the Detrimental Effect of Nitrogenous Heme Ligands on the Enzymatic Activity of Acanthamoeba castellanii CYP51 . Biochemistry 61:13, pages 1363-1377.
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Dmitri R. Davydov & Bhagwat Prasad. (2021) Assembling the P450 puzzle: on the sources of nonadditivity in drug metabolism. Trends in Pharmacological Sciences 42:12, pages 988-997.
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Vandna Sharma, Brian Shing, Lilian Hernandez-Alvarez, Anjan Debnath & Larissa M. Podust. (2020) Domain-Swap Dimerization of Acanthamoeba castellanii CYP51 and a Unique Mechanism of Inactivation by Isavuconazole . Molecular Pharmacology 98:6, pages 770-780.
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Jed N. LampePhDPhD. (2017) Advances in the Understanding of Protein-Protein Interactions in Drug Metabolizing Enzymes through the Use of Biophysical Techniques. Frontiers in Pharmacology 8.
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James R. Reed & Wayne L. Backes. (2017) Physical Studies of P450–P450 Interactions: Predicting Quaternary Structures of P450 Complexes in Membranes from Their X-ray Crystal Structures. Frontiers in Pharmacology 8.
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D. R. Davydov. (2016) Molecular organization of the microsomal oxidative system: a new connotation for an old term. Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry 10:1, pages 10-21.
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D.R. Davydov. (2015) Molecular organization of the microsomal oxidative system: a new connotation for an old term. Biomeditsinskaya Khimiya 61:2, pages 176-187.
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Dmitri R. Davydov, Nadezhda Y. Davydova, Elena V. Sineva & James R. Halpert. (2015) Interactions among Cytochromes P450 in Microsomal Membranes. Journal of Biological Chemistry 290:6, pages 3850-3864.
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James R. Reed & Wayne L. Backes. (2012) Formation of P450?P450 complexes and their effect on P450 function. Pharmacology & Therapeutics 133:3, pages 299-310.
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Dmitri R Davydov, James R Halpert, Jean-Paul Renaud & Gaston Hui Bon Hoa. (2003) Conformational heterogeneity of cytochrome P450 3A4 revealed by high pressure spectroscopy. Biochemical and Biophysical Research Communications 312:1, pages 121-130.
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James R Reed & Paul F Hollenberg. (2003) Examining the mechanism of stimulation of cytochrome P450 by cytochrome b5: the effect of cytochrome b5 on the interaction between cytochrome P450 2B4 and P450 reductase. Journal of Inorganic Biochemistry 97:3, pages 265-275.
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P. Hlavica, J. Schulze & D.F.V. Lewis. (2003) Functional interaction of cytochrome P450 with its redox partners: a critical assessment and update of the topology of predicted contact regions. Journal of Inorganic Biochemistry 96:2-3, pages 279-297.
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Peter Hlavica & David F. V. Lewis. (2008) Allosteric phenomena in cytochrome P450‐catalyzed monooxygenations. European Journal of Biochemistry 268:18, pages 4817-4832.
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Dmitri R. Davydov, Natalia A. Petushkova, Alexander I. Archakov & Gaston Hui Bon Hoa. (2000) Stabilization of P450 2B4 by Its Association with P450 1A2 Revealed by High-Pressure Spectroscopy. Biochemical and Biophysical Research Communications 276:3, pages 1005-1012.
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M.S.I. Dhami, M. Menon, D. V. Parke, M. Faisal Dhami & M. Afzal. (1997) Chronotoxicity as Related to Chronobiology. Drug Metabolism and Drug Interactions 13:4.
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Alexey Chernogolov, Sergey Usanov, Regine Kraft & Dieter Schwarz. (1994) Selective chemical modification of Cys 264 with diiodofluorescein iodacetamide as a tool to study the membrane topology of cytochrome P450scc (CYP11A1) . FEBS Letters 340:1-2, pages 83-88.
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Horacio A. Garda, Volker Kr�ger, Jaspreet Sidhu & Anton Stier. (1994) Heterogeneity in rabbit liver cytochrome P-450 LM2 observed by cation exchange HPLC: Partial biochemical characterization of the two major LM2 subfractions. Molecular and Cellular Biochemistry 141:1, pages 1-7.
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J. Blanck & K. Ruckpaul. 1993. Cytochrome P450. Cytochrome P450 581 597 .
Dmitri R. Davydov, Tatyana V. Knyushko & Gaston Hui Bon Hoa. (1992) High pressure induced inactivation of ferrous cytochrome P-450 LM2 (11B4) CO complex: Evidence for the presence of two conformers in the oligomer. Biochemical and Biophysical Research Communications 188:1, pages 216-221.
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A. Stier, V. Kruger, T. Eisbein & S. A. E. Finch. 1991. Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds. Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds 115 133 .
A. Stier, V. Krüger, T. Eisbein & S. A. E. Finch. 1991. Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds. Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds 93 113 .
D. Schwarz, J. Pirrwitz, H.W. Meyer, M.J. Coon & K. Ruckpaul. (1990) Membrane topology of microsomal cytochrome P-450: Saturation transfer EPR and freeze-fracture electron microscopy studies. Biochemical and Biophysical Research Communications 171:1, pages 175-181.
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Peter HILDEBRANDT, Horacio GARDA, Anton STIER, Galina I. BACHMANOVA, Irina P. KANAEVA & Alexander I. ARCHAKOV. (1989) Protein-protein interactions in microsomal cytochrome P-450 isozyme LM2 and their effect on substrate binding. European Journal of Biochemistry 186:1-2, pages 383-388.
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Thomas M. Jovin & Winchil L.C. Vaz. 1989. Biomembranes Part S. Biomembranes Part S 471 513 .
Christoph Richter, Josef Gut & Barbara C. Kunz. 1988. Fluorescence Studies on Biological Membranes. Fluorescence Studies on Biological Membranes 259 279 .
Peter Hlavica, Ines Golly & Jutta Wolf. (1987) Influence of N,N-dimethylaniline on the association of phenobarbital-induced cytochrome P-450 and NADPH-cytochrome c(P-450) reductase in a reconstituted rabbit liver microsomal enzyme system. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 915:1, pages 28-36.
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Michael Edidin. 1987. Membrane Structure and Function. Membrane Structure and Function 91 127 .
K.J. Netter. (1987) Mechanisms of monooxygenase induction and inhibition. Pharmacology & Therapeutics 33:1, pages 1-9.
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David D. Thomas. 1986. Techniques for the Analysis of Membrane Proteins. Techniques for the Analysis of Membrane Proteins 377 431 .
Magnus Ingelman-Sundberg. 1986. Cytochrome P-450. Cytochrome P-450 119 160 .
T. Bayerl, G. Klose, K. Ruckpaul & W. Schwarze. (1985) Interaction of hexane phosphonic acid diethyl ester with phospholipids in hepatic microsomes and reconstituted liposomes as studied by 31P-NMR. Biochimica et Biophysica Acta (BBA) - Biomembranes 812:2, pages 437-446.
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Jurgen BLANCK, Gerhard SMETTAN, Otto RISTAU, Magnus INGELMAN-SUNDBERG & Klaus RUCKPAUL. (1984) Mechanism of rate control of the NADPH-dependent reduction of cytochrome P-450 by lipids in reconstituted phospholipid vesicles. European Journal of Biochemistry 144:3, pages 509-513.
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D. Schwarz, K. Gast, H.W. Meyer, U. Lachmann, M.J. Coon & K. Ruckpaul. (1984) Incorporation of the cytochrome P-450 monooxygenase system into large unilamellar liposomes using octylglucoside, especially for measurements of protein diffusion in membranes. Biochemical and Biophysical Research Communications 121:1, pages 118-125.
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S L Wagner, W L Dean & R D Gray. (1984) Effect of a zwitterionic detergent on the state of aggregation and catalytic activity of cytochrome P-450LM2 and NADPH-cytochrome P-450 reductase.. Journal of Biological Chemistry 259:4, pages 2390-2395.
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