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Xenobiotica
the fate of foreign compounds in biological systems
Volume 12, 1982 - Issue 11
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Original Article

Insights into the active site of the cytochrome P-450 haemoprotein family-a unifying concept based on structural considerations

Pages 745-772 | Received 24 Aug 1982, Published online: 30 Sep 2009

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Read on this site (8)

Mukul Das & Subhash K. Khanna. (1997) Clinicoepidemiological, Toxicological, and Safety Evaluation Studies on Argemone Oil. Critical Reviews in Toxicology 27:3, pages 273-297.
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A. D. Rodrigues, D. F. V. Lewis, C. Ioannides & D. V. Parke. (1987) Spectral and kinetic studies of the interaction of imidazole anti-fungal agents with microsomal cytochromes P-450. Xenobiotica 17:11, pages 1315-1327.
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Milton Adesnik, Michael Atchison & Daniel W. Nebert. (1986) Genes for Cytochrome P-450 and Their Regulatio. Critical Reviews in Biochemistry 19:3, pages 247-305.
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Lev M. Weiner. (1986) Magnetic Resonance Study of the Structure and Functions of Cytochrome P45. Critical Reviews in Biochemistry 20:2, pages 139-200.
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David F. V. Lewis. (1986) Physical Methods in the Study of the Active Site Geometry of Cytochromes P-450. Drug Metabolism Reviews 17:1-2, pages 1-66.
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C. Ioannides, P. Y. Lum & D. V. Parke. (1984) Cytochrome P-448 and the activation of toxic chemicals and carcinogens. Xenobiotica 14:1-2, pages 119-137.
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Articles from other publishers (22)

M.S.I. Dhami, M. Menon, R. Aliling, M. Afzal, C.J. DiFonzo, B. Ali & G. Feuer. (1994) EFFECT OF ENVIRONMENTAL POLLUTANTS ON HEPATOCELLULAR FUNCTION IN RATS: 3-METHYLCHOLANTHRENE AND AROCLOR-1254. Drug Metabolism and Drug Interactions 11:4.
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L. S. Kaminsky, R. S. Obach & M. J. Fasco. 1993. Cytochrome P450. Cytochrome P450 183 194 .
Kaushal K. Upreti, Mukul Das & Subhash K. Khanna. (2006) Biochemical toxicology of argemone oil. I. effect on hepatic cytochrome P‐450 and xenobiotic metabolizing enzymes. Journal of Applied Toxicology 11:3, pages 203-209.
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Dennis E. Chapman, David J. Holbrook, Stephen G. Chaney, Iris H. Hall & Kuo-Hsiung Lee. (1989) In vitro inhibition of mouse hepatic mixed-function oxidase enzymes by helenalin and alantolactone. Biochemical Pharmacology 38:22, pages 3913-3923.
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C A Brown & S D Black. (1989) Membrane topology of mammalian cytochromes P-450 from liver endoplasmic reticulum. Journal of Biological Chemistry 264:8, pages 4442-4449.
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Ginette Sauret-Ignazi, Anastase Dardas & Jean Pelmont. (1988) Purification and properties of cytochrome P-450 from Moraxella sp.. Biochimie 70:10, pages 1385-1395.
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D.V. Parke, C. Ioannides & D.F.V. Lewis. (2016) Metabolic Activation of Carcinogens and Toxic Chemicals. Human Toxicology 7:5, pages 397-404.
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Costas Ioannides & Dennis V. Parke. (1987) The cytochromes P-448—A unique family of enzymes involved in chemical toxicity and carcinogenesis. Biochemical Pharmacology 36:24, pages 4197-4207.
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Dennis V. Parke. (1987) The role of enzymes in protection mechanisms for human health. Regulatory Toxicology and Pharmacology 7:3, pages 222-235.
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A Parkinson, P E Thomas, D E Ryan, L D Gorsky, J E Shively, J M Sayer, D M Jerina & W Levin. (1986) Mechanism of inactivation of rat liver microsomal cytochrome P-450c by 2-bromo-4'-nitroacetophenone.. Journal of Biological Chemistry 261:25, pages 11487-11495.
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Alan B. Frey, Gert Kreibich, Ashwani Wadhera, Lynn Clarke & David J. Waxman. (2002) 3-(Trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine photolabels a substrate-binding site of rat hepatic cytochrome P-450 form PB-4. Biochemistry 25:17, pages 4797-4803.
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James C. Veltman & Mahin D. Maines. (1986) Alterations of heme, cytochrome P-450, and steroid metabolism by mercury in rat adrenal. Archives of Biochemistry and Biophysics 248:2, pages 467-478.
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Katja Breskvar. (1986) The properties of cytochrome P-450 induced in the rat small intestine by estradiol. Steroids 48:1-2, pages 85-92.
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David F.V. Lewis, Costas Ioannides & Dennis V. Parke. (1986) Molecular dimensions of the substrate binding site of cytochrome P-448. Biochemical Pharmacology 35:13, pages 2179-2185.
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Shaun D. Black & Minor J. Coon. 1986. Cytochrome P-450. Cytochrome P-450 161 216 .
C. E. Castro, Ruth S. Wade & N. O. Belser. (2002) Biodehalogenation: reactions of cytochrome P-450 with polyhalomethanes. Biochemistry 24:1, pages 204-210.
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Costas Ioannides, Marcel Delaforge & Dennis V. Parke. (1985) Interactions of safrole and isosafrole and their metabolites with cytochromes P-450. Chemico-Biological Interactions 53, pages 303-311.
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Dennis V. Parke. (1985) The role of cytochrome P-450 in the metabolism of pollutants. Marine Environmental Research 17:2-4, pages 97-100.
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Caroline E. Phillipson, Costas Ioannides, David C.A. Barrett & Dennis V. Parke. (1985) The homogeneity of rat liver microsomal cytochrome P-448 activity and its role in the activation of benzo[a]pyrene to mutagens. International Journal of Biochemistry 17:1, pages 37-42.
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Ralph I. Murray, Mark T. Fisher, Peter G. Debrunner & Stephen G. Sligar. 1985. Metalloproteins. Metalloproteins 157 206 .
D. V. Parke & C. Ioannides. 1984. Disease, Metabolism and Reproduction in the Toxic Response to Drugs and Other Chemicals. Disease, Metabolism and Reproduction in the Toxic Response to Drugs and Other Chemicals 183 192 .
Mitsuru Haniu, Kerry T. Yasunobu & Irwin C. Gunsalus. (1983) Heme binding and substrate-protected cysteine residues in P-450cam. Biochemical and Biophysical Research Communications 116:1, pages 30-38.
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