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Xenobiotica
the fate of foreign compounds in biological systems
Volume 12, 1982 - Issue 10
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Research Article

The metabolism of [carboxyl-14C]aspirin in man

A. J. Hutt Department of Pharmacology, St Mary's Hospital Medical School, London, W2 1PG, UKs
,
J. Caldwell Department of Pharmacology, St Mary's Hospital Medical School, London, W2 1PG, UKs
&
R. L. Smith Department of Pharmacology, St Mary's Hospital Medical School, London, W2 1PG, UKs
Pages 601-610 | Received 18 Mar 1982, Published online: 22 Sep 2008

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A. J. Hutt, J. Caldwell & R. L. Smith. (1986) The metabolism of aspirin in man: a population study. Xenobiotica 16:3, pages 239-249.
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Jennifer B. Dressman, Anita Nair, Bertil Abrahamsson, Dirk M. Barends, D.W. Groot, Sabine Kopp, Peter Langguth, James E. Polli, Vinod P. Shah & Markus Zimmer. (2012) Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Acetylsalicylic Acid. Journal of Pharmaceutical Sciences 101:8, pages 2653-2667.
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Sanford P. Markey. 2012. Principles of Clinical Pharmacology. Principles of Clinical Pharmacology 153 172 .
Ramesh Mullangi, Kuldeep Sharma & Nuggehally R Srinivas. (2012) Review of HPLC methods and HPLC methods with mass spectrometric detection for direct determination of aspirin with its metabolite(s) in various biological matrices. Biomedical Chromatography, pages n/a-n/a.
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C T Dolphin, J Caldwell & R L Smith. (1987) Depression of oxidative metabolism of aspirin in mice via an interferon-associated mechanism in relation to Reye's syndrome. Journal of Pharmacy and Pharmacology 39:3, pages 228-230.
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Joan Jensen, Claus Cornett, Carl Erik Olsen, Jette Tjørnelund & Steen Honoré Hansen. (1993) Synthesis and structural elucidation of glutathione and N-aceyl-cysteine conjugates of 5-aminosalicylic acid. European Journal of Pharmaceutical Sciences 1:3, pages 143-150.
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C. R. SHORT, C. A. NEFF‐DAVIS, L. C. HSIEH, G. D. KORITZ, M. S. MALBROUGH, S. A. BARKER & L. E. DAVIS. (2008) Pharmacokinetics and elimination of salicylic acid in rabbits. Journal of Veterinary Pharmacology and Therapeutics 14:1, pages 70-77.
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D.K. Patel, A. Hesse, A. Ogunbona, L.J. Notarianni & P.N. Bennett. (2016) Metabolism of Aspirin after Therapeutic and Toxic Doses. Human & Experimental Toxicology 9:3, pages 131-136.
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Suresh Mallikaarjun, John H. Wood & H.Thomas Karnes. (1989) High-performance liquid chromatographic method for the determination of salicylic acid and its metabolites in urine by direct injection. Journal of Chromatography B: Biomedical Sciences and Applications 493, pages 93-104.
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C.T. Dolphin, J. Caldwell & R.L. Smith. (1987) Effect of interferon synthesis upon the metabolism of [carboxyl-14C]-aspirin in the mouse. Biochemical Pharmacology 36:15, pages 2437-2442.
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Hazel Peck, A.W. Stott & J.B. Turner. (1986) Separation of dihydroxybenzoic acids and trihydroxybenzoic acids by two-dimensional thin-layer chromatógraphy. Journal of Chromatography A 367, pages 289-292.
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. (2012) Communications. British Journal of Pharmacology 85:S1.
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W.H. Betts, M.W. Whitehouse, L.G. Cleland & B. Vernon-Roberts. (1985) In vitro antioxidant properties of potential biotransformaton products of salicylate, sulphasalazine and aminodypyrine. Journal of Free Radicals in Biology & Medicine 1:4, pages 273-280.
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D.R. Varma & T.L. Yue. (2012) Influence of age, sex, pregnancy and protein‐calorie malnutrition on the pharmacokinetics of salicylate in rats. British Journal of Pharmacology 82:1, pages 241-248.
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D.C. Mays, D.E. Sharp, C.A. Beach, R.A. Kershaw, J.R. Bianchine & N. Gerber. (1984) Improved method for the determination of aspirin and its metabolites in biological fluids by high-performance liquid chromatography: applications to human and animal studies. Journal of Chromatography B: Biomedical Sciences and Applications 311, pages 301-309.
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