Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 12, 1982 - Issue 10
10
Views
25
CrossRef citations to date
0
Altmetric
Research Article

The biotransformation of 17α-ethynyl[3H]estradiol in the rat: Irreversible binding and biliary metabolites

, , &
Pages 657-668 | Received 17 May 1982, Published online: 22 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

N. Radembino, M.- C. Dessalles, J.-H. Trouvin, P. M. Loiseau, P. Gayral, G. Mahuzier, M. Rapp, P. Labarre, D. Godeneche, J.-C. Madelmont, J.-C. Maurizis, A. Veyre & J.-L. Chabard. (1997) Tissue distribution and metabolism in rat of an ethynesulphonamide with filaricidal activity. Xenobiotica 27:1, pages 73-85.
Read now
J. L. Maggs, P. Morgan, F. Hussain, P. C. B. Page & B. K. Park. (1990) The metabolism of 2,4-dibromo-17α-ethynyl[6,7-3H]oestradiol in the rat. Xenobiotica 20:1, pages 45-54.
Read now
J. L. Maggs, S. F. M. Grimmer, M. L'E. Orme, A. M. Breckenridge, B. K. Park & I. T. Gilmore. (1983) The biliary and urinary metabolites of [3H]17α-ethynylestradiol in women. Xenobiotica 13:7, pages 421-431.
Read now
J. L. Maggs, P. S. Grabowski & B. K. Park. (1983) The enterohepatic circulation of the metabolites of 17α-ethynyl[3H]estradiol in the rat. Xenobiotica 13:10, pages 619-626.
Read now

Articles from other publishers (21)

R N Bawarshi-Nassar, A Hussain & P A Crooks. (1989) Nasal absorption of 17α-ethinyloestradiol in the rat. Journal of Pharmacy and Pharmacology 41:3, pages 214-215.
Crossref
N.M. Bonham, J.L. Maggs, P.C. Bulman-Page & B.K. Park. (1994) Structure-metabolism relationships of ring-A halogenated analogues of 17α-ethynyloestradiol. The Journal of Steroid Biochemistry and Molecular Biology 49:2-3, pages 203-211.
Crossref
Martin J. Wild, Philip S. Rudland & David J. Back. (1993) Metabolism of the oral contraceptive steroids ethynylestradiol, norgestimate and 3-ketodesogestrel by a human endometrial cancer cell line (HEC-1A) and endometrial tissue in vitro. The Journal of Steroid Biochemistry and Molecular Biology 45:5, pages 407-420.
Crossref
Michel Oettel & Ekkehard SchillingerW. Kuhnz, H. Blode & H. Zimmermann. 1999. Estrogens and Antiestrogens II. Estrogens and Antiestrogens II 261 322 .
P. Morgan, J.L. Maggs, P.C. Bulman-Page, F. Hussain & B.K. Park. (1992) The metabolism of 2- and 4-fluoro-17β- oestradiol in the rat and its implications for oestrogen carcinogenesis. Biochemical Pharmacology 43:5, pages 985-993.
Crossref
Philip C. Bulman Page, Fazal Hussain, Nicholas M. Bonham, Paul Morgan, James L. Maggs & B.Kevin Park. (1991) Regioselective synthesis of a-ring halogenated derivatives of 17α-ethynyloestradiol. Tetrahedron 47:16-17, pages 2871-2878.
Crossref
David J. Back, Steven Madden & Michael L'E. Orme. (1990) Gastrointestinal metabolism of contraceptive steroids. American Journal of Obstetrics and Gynecology 163:6, pages 2138-2145.
Crossref
Andrew M. Standeven, Yuenian E. Shi, Jacqueline F. Sinclair, Peter R. Sinclair & James D. Yager. (1990) Metabolism of the liver tumor promoter ethinyl estradiol by primary cultures of rat hepatocytes. Toxicology and Applied Pharmacology 102:3, pages 486-496.
Crossref
G.M. Pacifici & D.J. Back. (1988) Sulphation and glucuronidation of ethinyloestradiol in human liver In vitro. Journal of Steroid Biochemistry 31:3, pages 345-349.
Crossref
J.L. Maggs & B.K. Park. (1988) Drug-protein conjugates—XVI. Biochemical Pharmacology 37:4, pages 743-748.
Crossref
SM Rogers, DJ Back & ML Orme. (1987) Intestinal metabolism of ethinyloestradiol and paracetamol in vitro: studies using Ussing chambers.. British Journal of Clinical Pharmacology 23:6, pages 727-734.
Crossref
HS Purba, JL Maggs, ML Orme, DJ Back & BK Park. (2012) The metabolism of 17 alpha‐ethinyloestradiol by human liver microsomes: formation of catechol and chemically reactive metabolites.. British Journal of Clinical Pharmacology 23:4, pages 447-453.
Crossref
Harpal S. Purba, David J. Back & Alasdair M. Breckenridge. (1986) Inhibition of estrogen 2-hydroxylase. Journal of Steroid Biochemistry 24:5, pages 1091-1093.
Crossref
Judith H. Riviere & D.J. Back. (1986) Inhibition of ethinyloestradiol and tolbutamide metabolism by quinoline derivatives in vitro. Chemico-Biological Interactions 59, pages 301-308.
Crossref
Judith H. Riviere & D.J. Back. (1985) Effect of mefloquine on hepatic drug metabolism in the rat: Comparative study with primaquine. Biochemical Pharmacology 34:4, pages 567-571.
Crossref
DJ Back, JL Maggs, HS Purba, S Newby & BK Park. (2012) 2‐Hydroxylation of ethinyloestradiol in relation to the oxidation of sparteine and antipyrine.. British Journal of Clinical Pharmacology 18:4, pages 603-607.
Crossref
Max Caviezel, Werner K. Lutz, Urs Minini & Christian Schlatter. (1984) Interaction of estrone and estradiol with DNA and protein of liver and kidney in rat and hamster in vivo and in vitro. Archives of Toxicology 55:2, pages 97-103.
Crossref
. (2012) POSTER COMMUNICATIONS. British Journal of Pharmacology 80:S1.
Crossref
J.L. Maggs, P.S. Grabowski & B.K. Park. (1983) Drug protein conjugates—III. Inhibition of the irreversible binding of ethinylestradiol to rat liver microsomal protein by mixed-function oxidase inhibitors, ascorbic acid and thiols. Journal of Steroid Biochemistry 19:3, pages 1273-1278.
Crossref
James L. Maggs, Peter S. Grabowski & B.Kevin Park. (1983) Drug-protein conjugates—V. Biochemical Pharmacology 32:18, pages 2793-2800.
Crossref
James L. Maggs, Peter S. Grabowski & B.Kevin Park. (1983) Protection of catechol oestrogen from oxidation during enzymic hydrolysis of biliary conjugates. Journal of Steroid Biochemistry 19:2, pages 1235-1237.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.