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Xenobiotica
the fate of foreign compounds in biological systems
Volume 12, 1982 - Issue 3
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Research Article

Metabolism and excretion of a chromone carboxylic acid (FPL 52757) in various animal species

B. Clark Fisons Plc, Pharmaceutical Division, Bakewell Road, Loughborough, Leicestershire, UK
,
D. A. Smith Fisons Plc, Pharmaceutical Division, Bakewell Road, Loughborough, Leicestershire, UK
,
C. T. Eason Fisons Plc, Pharmaceutical Division, Bakewell Road, Loughborough, Leicestershire, UK
&
D. V. Parke Fisons Plc, Pharmaceutical Division, Bakewell Road, Loughborough, Leicestershire, UK; Division of Pharmacology and Toxicology, Department of Biochemistry, University of Surrey, Guildford GU2 5XH, UK
Pages 147-153 | Received 23 Nov 1981, Published online: 22 Sep 2008

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Peter Dogterom, Gerhard Zbinden & Gerd K. Reznik. (1992) Cardiotoxicity of Vasodilators and Positive Inotropic/Vasodilating Drugs in Dogs: An Overview. Critical Reviews in Toxicology 22:3-4, pages 203-241.
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Dennis A. Smith, Kevan Brown & Michael G. Neale. (1985) Chromone-2-Carboxylic Acids: Roles of Acidity and Lipophilicity in Drug Disposition. Drug Metabolism Reviews 16:4, pages 365-388.
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C. T. Eason, D. V. Parke, B. Clark & D. A. Smith. (1982) The mechanism of hepatotoxicity of a chromone carboxylic acid (FPL 52757) in the dog. Xenobiotica 12:3, pages 155-164.
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Articles from other publishers (11)

Dong Xiao, Anandan Palani, Michael Sofolarides, Robert Aslanian, Robert E. WestJr.Jr., Shirley M. Williams, Ren-Long Wu, Joyce Hwa, Christopher Sondey, Jean Lachowicz & Walter A. Korfmacher. (2012) Fused bicycles as arylketone bioisosteres leading to potent, orally active thiadiazole H3 antagonists. Bioorganic & Medicinal Chemistry Letters 22:9, pages 3354-3357.
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Barry Lynch, Ryan Simon & Ashley Roberts. (2011) In vitro and in vivo assessment of the genotoxic activity of aloesin. Regulatory Toxicology and Pharmacology 61:2, pages 215-221.
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Huadong Tang & Michael Mayersohn. (2006) A global examination of allometric scaling for predicting human drug clearance and the prediction of large vertical allometry**This work was presented at the American Association of Pharmaceutical Scientists Annual meeting, Salt Lake City, USA, Oct. 26, 2003.. Journal of Pharmaceutical Sciences 95:8, pages 1783-1799.
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Teh-Min Hu & William L. Hayton. (2015) Allometric scaling of xenobiotic clearance: Uncertainty versus universality. AAPS PharmSci 3:4, pages 30-43.
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C L Broadhead, G Betton, R Combes, S Damment, D Everett, C Garner, Z Godsafe, G Healing, R Heywood, M Jennings, C Lumley, G Oliver, D Smith, D Straughan, J Topham, R Wallis, S Wilson & P Buckley. (2016) Prospects for reducing and refining the use of dogs in the regulatory toxicity testing of pharmaceuticals. Human & Experimental Toxicology 19:8, pages 440-447.
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John F. Darbyshire & John Caldwell. (2004) Stereoselectivity of the aliphatic hydroxylation of 6‐ n ‐propylchromone‐2‐carboxylic acid in rat and guinea pig . Chirality 5:3, pages 191-198.
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Charles T. Eason, Frank W. Bonner & Dennis V. Parke. (1990) The importance of pharmacokinetic and receptor studies in drug safety evaluation. Regulatory Toxicology and Pharmacology 11:3, pages 288-307.
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D. V. Parke. 1987. The Future of Predictive Safety Evaluation. The Future of Predictive Safety Evaluation 3 38 .
Dennis V. Parke. (2016) Adverse Effects of Drugs — Their Causes and Prevention. Journal of the Royal Society of Health 105:2, pages 39-46.
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A.J. Clarke, B. Clark, C.T. Eason & D.V. Parke. (1985) An assessment of a toxicological incident in a drug development program and its implications. Regulatory Toxicology and Pharmacology 5:1, pages 109-119.
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J.L. Suschitzky & P. Sheard. 1985. 1 61 .

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