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Xenobiotica
the fate of foreign compounds in biological systems
Volume 12, 1982 - Issue 3
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Research Article

Pharmacokinetics and distribution of the new antihypertensive agent pinacidil in rat, dog and man

E. Eilertsen Departments of 1pharmacology 2Biology 3 Analytical Chemistry, Leo Pharmaceutical Products Ltd, DK-2750 Ballerup, Denmark
,
J. W. Wart Departments of 1pharmacology 2Biology 3 Analytical Chemistry, Leo Pharmaceutical Products Ltd, DK-2750 Ballerup, Denmark
,
M. P. Magnussen Departments of 1pharmacology 2Biology 3 Analytical Chemistry, Leo Pharmaceutical Products Ltd, DK-2750 Ballerup, Denmark
,
H. Sørensen Departments of 1pharmacology 2Biology 3 Analytical Chemistry, Leo Pharmaceutical Products Ltd, DK-2750 Ballerup, Denmark
&
E. Arrigoni-Martelli Departments of 1pharmacology 2Biology 3 Analytical Chemistry, Leo Pharmaceutical Products Ltd, DK-2750 Ballerup, Denmark
Pages 177-185 | Received 16 Sep 1981, Published online: 22 Sep 2008

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Shiying Li, Yong Lei & Jiande DZ Chen. (2017) Roles of ATP sensitive potassium channel in modulating gastric tone and accommodation in dogs. Scandinavian Journal of Gastroenterology 52:5, pages 515-522.
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K. Sakamoto & Y. Nakamura. (1994) Stereoselective disposition and metabolism of pinacidil in rat. Xenobiotica 24:4, pages 329-338.
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Michael P. Cinquegrani & Chang-Seng Liang. (1988) Antihypertensive Effects of Pinacidil in Patients with and Without Indomethacin Pretreatment. Clinical and Experimental Hypertension. Part A: Theory and Practice 10:3, pages 411-431.
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E. Eilertsen, M. P. Magnussen, H. J. Petersen, N. Rastrup-Andersen, H. Sørensen & E. Arrigoni-Martelli. (1982) Metabolism of the new antihypertensive agent pinacidil in rat, dog and man. Xenobiotica 12:3, pages 187-196.
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Articles from other publishers (19)

Mark A. Simmons. 2009. xPharm: The Comprehensive Pharmacology Reference. xPharm: The Comprehensive Pharmacology Reference 1 7 .
P. Girard, J. L. Saumet, F. Dubois & J. P. Boissel. (1993) Pharmacodynamic model of the haemodynamic effects of pinacidil in normotensive volunteers. European Journal of Clinical Pharmacology 44:2, pages 177-182.
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Jens Erik Nielsen-Kudsk, Claus Brøckner Nielsen, Søren Mellemkjaer & Charlotte Siggaard. (1990) Lack of Effect of Pinacidil on Theophylline Pharmacokinetics and Metabolism in Man. Pharmacology & Toxicology 67:2, pages 156-158.
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A. H. Weston. 1990. Pharmacology of Antihypertensive Therapeutics. Pharmacology of Antihypertensive Therapeutics 643 676 .
R. Ayesh, M. Al-Waiz, A. McBurney, SC Mitchell, J.R. Idle, JW Ward & RL Smith. (1989) Variable metabolism of pinacidil: lack of correlation with the debrisoquine and trimethylamine C- and N-oxidative polymorphisms.. British Journal of Clinical Pharmacology 27:4, pages 423-428.
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Claus Brøckner Nielsen, Søren Mellemkjær & Folmer Nielsen‐Kudsk. (2009) Pinacidil Uptake and Effects in the Isolated Rabbit Heart. Pharmacology & Toxicology 64:1, pages 14-19.
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A. H. Weston. (1989) Smooth muscle K+ channel openers; their pharmacology and clinical potential. Pfl�gers Archiv European Journal of Physiology 414:S1, pages S99-S105.
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Michael R. Goldberg, Frank W. Rockhold, W. Leigh Thompson & Karl A. DeSante. (2013) Clinical Pharmacokinetics of Pinacidil, A Potassium Channel Opener, in Hypertension. The Journal of Clinical Pharmacology 29:1, pages 33-40.
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. (2012) POSTER COMMUNICATIONS. British Journal of Pharmacology 95:S2.
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Lars M. Videbæk, Christian Aalkjær & Michael J. Mulvany. (2012) Pinacidil opens K + ‐selective channels causing hyperpolarization and relaxation of noradrenaline contractions in rat mesenteric resistance vessels . British Journal of Pharmacology 95:1, pages 103-108.
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Alan McBurney, Peter R. Farrow & John W. Ward. (1988) Effects of food on the bioavailability of sustained‐release pinacidil in humans. Journal of Pharmaceutical Sciences 77:1, pages 68-69.
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M. C. M. Rijk & Th. Thien. (2013) Intravenous Pinacidil in the Acute Treatment of Hypertension. The Journal of Clinical Pharmacology 27:7, pages 468-474.
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Marlene L. Cohen. (2008) Pinacidil monohydrate—a novel vasodilator: Review of preclinical pharmacology and mechanism of action. Drug Development Research 9:4, pages 249-258.
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Marlene L. Cohen & Walter E. Colbert. (2008) Comparison of the effects of pinacidil and its metabolite, pinacidil‐N‐oxide, in isolated smooth and cardiac muscle. Drug Development Research 7:2, pages 111-124.
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Marta Hamilton, Khadiga Z. Farid & David P. Henry. (1986) Liquid chromatographic determination of pinacidil, a new antihypertensive drug, and its major metabolite, pinacidil N-oxide, in plasma. Journal of Chromatography B: Biomedical Sciences and Applications 375, pages 359-367.
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Edoardo Arrigoni‐Martelli & Jim Finucane. (2007) Pinacidil. Cardiovascular Drug Reviews 3:1, pages 133-151.
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A McBurney, PR Farrow, S Ainsworth & JW Ward. (1985) Serum concentrations and urinary excretion of pinacidil and its major metabolite, pinacidil pyridine-N-oxide following i.v. and oral administration in healthy volunteers.. British Journal of Clinical Pharmacology 19:1, pages 91-94.
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JW Ward. (2012) Pinacidil monotherapy for hypertension.. British Journal of Clinical Pharmacology 18:2, pages 223-225.
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J. W. Ward, A. McBurney, P. R. Farrow & P. Sharp. (1984) Pharmacokinetics and hypotensive effect in healthy volunteers of pinacidil, a new potent vasodilator. European Journal of Clinical Pharmacology 26:5, pages 603-608.
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