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Xenobiotica
the fate of foreign compounds in biological systems
Volume 12, 1982 - Issue 3
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Research Article

Lindane metabolism by human and rat liver microsomes†

J. F. Fitzloff Department of Medicinal Chemistry, University of Illinois at the Medical Center, Chicago, Illinois, 60612, USA
,
J. Portig Department of Medicinal Chemistry, University of Illinois at the Medical Center, Chicago, Illinois, 60612, USA
&
K. Stein Department of Medicinal Chemistry, University of Illinois at the Medical Center, Chicago, Illinois, 60612, USA; Institut für Toxikologie und Pharmakologie, Philips-Universität Marburg, D-3550 Marburg/Lahn, FR Germany; To whom correspondence should be addressed. P.O. Box 6998, Room 545, Chicago, Illinois, 60680, USA
Pages 197-202 | Received 17 Aug 1981, Published online: 22 Sep 2008

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J. Portig, K. Stein & H. W. Vohland. (1989) Preferential distribution of α-hexachlorocyclohexane into cerebral white matter. Xenobiotica 19:1, pages 123-130.
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J. F. Fitzloff & J. C. Pan. (1984) Epoxidation of the lindane metabolite, β-PCCH, by human- and rat-liver microsomes. Xenobiotica 14:7, pages 599-604.
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Articles from other publishers (19)

Matthew Boyce, Kristin A. Favela, Jessica A. Bonzo, Alex Chao, Lucina E. Lizarraga, Laura R. Moody, Elizabeth O. Owens, Grace Patlewicz, Imran Shah, Jon R. Sobus, Russell S. Thomas, Antony J. Williams, Alice Yau & John F. Wambaugh. (2023) Identifying xenobiotic metabolites with in silico prediction tools and LCMS suspect screening analysis. Frontiers in Toxicology 5.
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Rebecca A. Fanning, Deirdre P. Campion, Maeve O’Shea, Michael F. Carey & John J. O’Connor. (2017) A comparison of the effects of lindane and FeCl 3 /ADP on spontaneous contractions in isolated rat or human term myometrium. Reproductive Toxicology 74, pages 164-173.
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Edward L. Croom, Timothy J. Shafer, Marina V. Evans, William R. Mundy, Chris R. Eklund, Andrew F.M. Johnstone, Cina M. Mack & Rex A. Pegram. (2015) Improving in vitro to in vivo extrapolation by incorporating toxicokinetic measurements: A case study of lindane-induced neurotoxicity. Toxicology and Applied Pharmacology 283:1, pages 9-19.
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Sicco H. Brandsma, Leo T.M. van der Ven, Jacob de Boer & Pim E.G. Leonards. (2009) Identification of Hydroxylated Metabolites of Hexabromocyclododecane in Wildlife and 28-days Exposed Wistar Rats. Environmental Science & Technology 43:15, pages 6058-6063.
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. (2005) Opinion of the Scientific Panel on contaminants in the food chain [CONTAM] related to gamma-HCH and other hexachlorocyclohexanes as undesirable substances in animal feed. EFSA Journal 3:7, pages 250.
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R Henschler, K.E Appel, C.M Heyworth & H Glatt. (2001) Proliferation and differentiation of murine haemopoietic progenitor cells in stroma-free culture in the presence of metabolites of chlorinated pesticides. Toxicology in Vitro 15:1, pages 31-37.
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Peter Ludwig, Heinrich Hühnerfuss, Wilfried A. König & Winfried Gunkel. (1992) Gas chromatographic separation of the enantiomers of marine pollutants. Part 3. Enantioselective degradation of α-hexachlorocyclohexane and γ-hexachlorocyclohexane by marine microorganisms. Marine Chemistry 38:1-2, pages 13-23.
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Kenneth L. KirkKenneth L. Kirk. 1991. Biochemistry of the Elemental Halogens and Inorganic Halides. Biochemistry of the Elemental Halogens and Inorganic Halides 239 285 .
. 1989. Metabolic Maps of Pesticides. Metabolic Maps of Pesticides 244 255 .
Ursula Juhl, Konrad Blum & Irene Witte. (1989) The in vitro metabolites of 2,4,6-trichlorophenol and their DNA strand breaking properties. Chemico-Biological Interactions 69:4, pages 333-344.
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George W. Ware. 1988. Reviews of Environmental Contamination and Toxicology. Reviews of Environmental Contamination and Toxicology 147 160 .
Luis A. Videla, Silvia B. De M. Barros, Kiyoko Simizu & Virgínia B. C. Junqueira. (1988) Liver and biliary levels of glutathione and thiobarbituric acid reactants after acute lindane intoxication. Cell Biochemistry and Function 6:1, pages 47-52.
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E.B. Brittebo, P.G. Högman & I. Brandt. (1987) Epithelial binding of hexachlorocyclohexanes in the respiratory and upper alimentary tracts: A comparison between the α-, β- and γ-isomers in mice. Food and Chemical Toxicology 25:10, pages 773-780.
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Amin A. Nomeir & Nicolas P. Hajjar. 1987. Reviews of Environmental Contamination and Toxicology. Reviews of Environmental Contamination and Toxicology 1 22 .
Paul T. Liu & Donald P. Morgan. (1986) Comparative toxicity and biotransformation of lindane in C57BL/6 and DBA/2 mice. Life Sciences 39:14, pages 1237-1244.
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Max T. Baker, Rita M. Nelson & Russell A. Van Dyke. (1985) The formation of chlorobenzene and benzene by the reductive metabolism of lindane in rat liver microsomes. Archives of Biochemistry and Biophysics 236:2, pages 506-514.
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YIN-TAK WOO, DAVID Y. LAI, JOSEPH C. ARCOS & MARY F. ARGUS. 1985. Aliphatic and Polyhalogenated Carcinogens. Aliphatic and Polyhalogenated Carcinogens 415 462 .
R. M. Macholz & M. Kujawa. 1985. Residue Reviews. Residue Reviews 119 149 .
Russell A. Van Dyke. (1983) Halogenated Anaesthetic Hepatotoxicity— Is the Answer Close at Hand?. Clinics in Anaesthesiology 1:2, pages 485-506.
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