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Xenobiotica
the fate of foreign compounds in biological systems
Volume 12, 1982 - Issue 1
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Research Article

Metabolism of 2,2′,5,5′-tetrachlorobiphenyl: formation of mono- and bis-methyl sulphone metabolites with a selective affinity for the lung and kidney tissues in mice

Å. Bergman Section of Organic Chemistry, Environmental Toxicology Unit, Wallenberg Laboratory, University of Stockholm, S-106 91 Stockholm, Sweden
,
I. Brandt Department of Pharmacology, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Biomedical Centre Box 573, S-751 23 Uppsala, Sweden
,
P. O. Darnerud Department of Pharmacology, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Biomedical Centre Box 573, S-751 23 Uppsala, Sweden
&
C. A. Wachtmeister Section of Organic Chemistry, Environmental Toxicology Unit, Wallenberg Laboratory, University of Stockholm, S-106 91 Stockholm, Sweden
Pages 1-7 | Received 03 Jul 1981, Published online: 22 Sep 2008

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Stephen H. Safe. (1994) Polychlorinated Biphenyls (PCBs): Environmental Impact, Biochemical and Toxic Responses, and Implications for Risk Assessment. Critical Reviews in Toxicology 24:2, pages 87-149.
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P. O. Darnerud, I. Brandt, E. Klasson-Wehler, Å. Bergman, R. D'argy, L. Dencker & G. O. Sperber. (1986) 3,3′,4,4′-Tetrachloro[14C]biphenyl in pregnant mice: enrichment of phenol and methyl sulphone metabolites in late gestational fetuses. Xenobiotica 16:4, pages 295-306.
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Izabela Kania-Korwel, Hongxia Zhao, Karin Norstrom, Xueshu Li, Keri C. Hornbuckle & Hans-Joachim Lehmler. (2008) Simultaneous extraction and clean-up of polychlorinated biphenyls and their metabolites from small tissue samples using pressurized liquid extraction. Journal of Chromatography A 1214:1-2, pages 37-46.
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. (2005) Opinion of the Scientific Panel on contaminants in the food chain [CONTAM] related to the presence of non dioxin-like polychlorinated biphenyls (PCB) in feed and food. EFSA Journal 3:11, pages 284.
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Yoichi Nakanishi, Shoji Tokunaga, Koichi Takayama & Kazuyoshi Kuwano. (2005) Cardiac, pulmonary and renal function in Yusho patients. Journal of Dermatological Science Supplement 1:1, pages S33-S38.
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John W. Nichols. 2002. The Practical Applicability of Toxicokinetic Models in the Risk Assessment of Chemicals. The Practical Applicability of Toxicokinetic Models in the Risk Assessment of Chemicals 109 133 .
Robert J. Letcher, Eva Klasson-Wehler & Ake Bergman. 2000. Volume 3 Anthropogenic Compounds Part K. Volume 3 Anthropogenic Compounds Part K 315 359 .
W.Harvey Newsome & David Davies. (1996) Determination of PCB metabolites in Canadian human milk. Chemosphere 33:3, pages 559-565.
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Eva Klasson Wehler, Lotta Hovander & Bert-Ove Lund. (1996) 2,2‘,4,5,5‘-Pentachlorobiphenyl:  Comparative Metabolism in Mink ( Mustela vison ) and Mouse . Chemical Research in Toxicology 9:8, pages 1340-1349.
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Seija Sinkkonen. (1993) Environmental analysis of chlorinated aromatic thioethers, sulphoxides and sulphones. Journal of Chromatography A 642:1-2, pages 47-52.
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A. Parkinson, P.E. Thomas, D.E. Ryan, W. Levin, T. Fujita & S. Safe. (1988) Induction of rat liver microsomal cytochrome P-450 isozymes and epoxide hydrolase by a series of 4′-substituted-2,3,4,5-tetrachlorobiphenyls. Toxicology 53:2-3, pages 289-300.
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Ingvar Brandt & Åke Bergman. (1987) PCB methyl sulphones and related compounds: identification of target cells and tissues in different species. Chemosphere 16:8-9, pages 1671-1676.
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A. -M. Drotar & R. Fall. (1985) Microbial methylation of benzenethiols and release of methylthiobenzenes. Experientia 41:6, pages 762-764.
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Ingvar Brandt, Per Ola Darnerud & Åke Bergman. (2009) Degradation to 14 CO 2 of 4,4,‐bis[(2‐ 14 C)‐ethylsulphonyl]‐2,2′,5,5′‐tetrachlorobiphenyl . Acta Pharmacologica et Toxicologica 55:5, pages 429-430.
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Craig Harris & William S. Bradshaw. (1984) Alterations in liver ultrastructure and induction of UDP-glucuronyltransferase in the rat following prenatal exposure to 3,4,3?,4?-tetrachlorobiphenyl. Archives of Environmental Contamination and Toxicology 13:6, pages 715-721.
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B. Bush, J. Snow & R. Koblintz. (1984) Polychlorobiphenyl (PCB) congeners,p,p?-DDE, and hexachlorobenzene in maternal and fetal cord blood from mothers in upstate New York. Archives of Environmental Contamination and Toxicology 13:5, pages 517-527.
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Ingvar Brandt, Abdulmalik Mohammed, Annika Lydéen & Premysl Slanina. (2009) Disposition of some Sulphur‐containing Hexachlorobenzene (HCB) Metabolites: Affinity of Methylsulphonylpentachlorobenzene for the Gray Matter of Brain, the Lungs and the Adrenal Zona reticularis **. Acta Pharmacologica et Toxicologica 54:5, pages 352-360.
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E. Klasson‐Wehler, A. L. Bergman & C. A. Wachtmeister. (2006) Synthesis of 4,4′‐BIS([ 3 H]methylsulphonyl)‐2,2′,5,5′‐tetrachlorobiphenyl . Journal of Labelled Compounds and Radiopharmaceuticals 20:12, pages 1407-1412.
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