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Xenobiotica
the fate of foreign compounds in biological systems
Volume 12, 1982 - Issue 4
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Research Article

Urinary metabolite profile of tiaramide in man and in some animal species

H. Noguchi Research Laboratories, Fujisawa Pharmaceutical Co., Ltd, 1–6, Kashima-2-chome, Yodogawa-ku, Osaka, 532, Japan
,
K. Tada Research Laboratories, Fujisawa Pharmaceutical Co., Ltd, 1–6, Kashima-2-chome, Yodogawa-ku, Osaka, 532, Japan
&
K. Iwasaki Research Laboratories, Fujisawa Pharmaceutical Co., Ltd, 1–6, Kashima-2-chome, Yodogawa-ku, Osaka, 532, Japan
Pages 211-220 | Received 01 Nov 1981, Published online: 22 Sep 2008

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T. Shiraga, K. Iwasaki, K. Takeshita, H. Matsuda, T. Niwa, Z. Tozuka, T. Hata & F. P. Guengerich. (1995) Species- and gender-related differences in amine, alcohol and phenol sulphoconjugations. Xenobiotica 25:10, pages 1063-1071.
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K. Iwasaki, T. Shiraga, K. Tada, K. Noda & H. Noguchi. (1986) Age- and sex-related changes in amine sulphoconjugations in Sprague-Dawley strain rats. Comparison with phenol and alcohol sulphoconjugations. Xenobiotica 16:8, pages 717-723.
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K. Iwasaki, T. Shiraga, K. Noda, K. Tada & H. Noguchi. (1986) N-Sulphoconjugation of alicyclic, alkyl- and aryl-amines in vivo and in vitro. Xenobiotica 16:7, pages 651-659.
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K. Iwasaki, T. Shiraga, K. Noda, K. Tada & H. Noguchi. (1983) Metabolism of tiaramide in vitro III. Sulphoconjugation of alicyclic amine and alcoholic hydroxyl group by hepatic 105 000 g supernatants. Xenobiotica 13:9, pages 565-574.
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K. Iwasaki, T. Shiraga, K. Noda, K. Tada & H. Noguchi. (1983) Terminal N-sulphoconjugation of an alicyclic amine (piperazine), identified as a new metabolite of tiaramide in mouse and rat. Xenobiotica 13:5, pages 273-278.
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K. Iwasaki, H. Noguchi, T. Kamataki & R. Kato. (1982) Metabolism of tiaramide in vitro: I. Oxidative metabolism of tiaramide by human and rat liver microsomes. Xenobiotica 12:4, pages 221-226.
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H. Noguchi & K. Iwasaki. (1982) Metabolism of tiaramide in vitro II. Oxidation of piperazineethanol group in tiaramide by 105 000 g supernatants from monkey and rat liver. Xenobiotica 12:8, pages 499-508.
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Articles from other publishers (4)

Teruko Imai. (2007) Species difference of drug metabolism: difficulty of prediction of drug disposition in human from animal data. Drug Delivery System 22:1, pages 48-53.
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Kazuhide Iwasaki, Yoji Tokuma, Kosei Noda & Hideyo Noguchi. (1994) Age- and sex-related changes of sulfotransferase activities in the rat. Chemico-Biological Interactions 92:1-3, pages 209-217.
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Gerard J. Mulder. (1986) Sex differences in drug conjugation and their consequences for drug toxicity. Sulfation, glucuronidation and gluthatione conjugation. Chemico-Biological Interactions 57:1, pages 1-15.
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Ryan J. HuxtableW. Mark Lafranconi. 1986. Biochemistry of Sulfur. Biochemistry of Sulfur 413 436 .

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