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Xenobiotica
the fate of foreign compounds in biological systems
Volume 12, 1982 - Issue 4
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Research Article

The metabolism of 4-(4-hydroxyphenyl)butan-2-one (raspberry ketone) in rats, guinea-pigs and rabbits

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Pages 249-257 | Received 01 Nov 1981, Published online: 22 Sep 2008

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Read on this site (4)

Finn Bjøsrn Gjertsen, Einar Solheim & Ronald R. Scheline. (1988) Metabolism of aromatic plant ketones in rats: Acetovanillone and paeonol. Xenobiotica 18:2, pages 225-234.
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Y. Nishizawa, S. Abe, K. Yamada, T. Nakamura, I. Yamatsu & K. Kinoshita. (1987) Identification of urinary and microsomal metabolites of geranylgeranylacetone in rats. Xenobiotica 17:5, pages 575-584.
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P. Monge, E. Solheim & R. R. Scheline. (1984) Dihydrochalcone metabolism in the rat: Phloretin. Xenobiotica 14:12, pages 917-924.
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A. Walde, B. Ve, R. R. Scheline & P. Monge. (1983) p-Cymene metabolism in rats and guinea-pigs. Xenobiotica 13:8, pages 503-512.
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Articles from other publishers (19)

Hamza Mostafa, Alex CheokTomás Meroño, Cristina Andres-Lacueva & Ana Rodriguez-Mateos. (2023) Biomarkers of Berry Intake: Systematic Review Update. Journal of Agricultural and Food Chemistry 71:31, pages 11789-11805.
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Naoto Uramaru, Azusa Kawashima, Makoto Osabe & Toshiyuki Higuchi. (2023) Rhododendrol, a reductive metabolite of raspberry ketone, suppresses the differentiation of 3T3‑L1 cells into adipocytes. Molecular Medicine Reports 27:2.
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Dushyant Kshatriya, Lihong Hao & Nicholas T. Bello. (2023) Metabolic gene signature in white adipose tissue of oral doses raspberry ketone [4-(4-hydroxyphenyl)-2-butanone] that prevent diet-induced weight gain and induce loss of righting reflex. Food and Chemical Toxicology 171, pages 113540.
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Donald L. Bjerke, Shengde Wu, Kazumasa Wakamatsu, Shosuke Ito, Jiazhen Wang, Timothy Laughlin & Tomohiro Hakozaki. (2022) A framework to mitigate the risk of chemical leukoderma: Consumer products. Regulatory Toxicology and Pharmacology 131, pages 105157.
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Xiaoping Li, Teng Wei, Min Wu, Fang Chen, Peng Zhang, Ze‐yuan Deng & Ting Luo. (2021) Potential metabolic activities of raspberry ketone. Journal of Food Biochemistry 46:1.
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Shailaja Rao, Mallesh Kurakula, Nagarjuna Mamidipalli, Papireddy Tiyyagura, Bhaumik Patel & Ravi Manne. (2021) Pharmacological Exploration of Phenolic Compound: Raspberry Ketone—Update 2020. Plants 10:7, pages 1323.
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M. Ulaszewska, M. Garcia-Aloy, N. Vázquez-Manjarrez, M. T. Soria-Florido, R. Llorach, F. Mattivi & C. Manach. (2020) Food intake biomarkers for berries and grapes. Genes & Nutrition 15:1.
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Gyeong Han Jeong & Tae Hoon Kim. (2020) Radiolytic Cyclization Products of Phloridzin as Potent Anti‐Glycation Agents. Chemistry & Biodiversity.
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Bo Yuan, Danyue Zhao, Dushyant Kshatriya, Nicholas T. Bello, James E. Simon & Qingli Wu. (2020) UHPLC-QqQ-MS/MS method development and validation with statistical analysis: Determination of raspberry ketone metabolites in mice plasma and brain. Journal of Chromatography B 1149, pages 122146.
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Danyue Zhao, Bo Yuan, Dushyant Kshatriya, Andrew Polyak, James E. Simon, Nicholas T. Bello & Qingli Wu. (2020) Influence of Diet‐Induced Obesity on the Bioavailability and Metabolism of Raspberry Ketone (4‐(4‐Hydroxyphenyl)‐2‐Butanone) in Mice. Molecular Nutrition & Food Research 64:8, pages 1900907.
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A.M. Api, D. Belsito, S. Biserta, D. Botelho, M. Bruze, G.A. BurtonJr.Jr., J. Buschmann, M.A. Cancellieri, M.L. Dagli, M. Date, W. Dekant, C. Deodhar, A.D. Fryer, S. Gadhia, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, D.C. Liebler, M. Na, D. O'Brien, A. Patel, T.M. Penning, G. Ritacco, F. Rodriguez-Ropero, J. Romine, N. Sadekar, D. Salvito, T.W. Schultz, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura & S. Tsang. (2019) RIFM fragrance ingredient safety assessment, 4-(p-hydroxyphenyl)-2-butanone, CAS Registry Number 5471-51-2. Food and Chemical Toxicology 134, pages 110948.
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Dalia Fouad, Amira Badr & Hala A. Attia. (2019) Hepatoprotective activity of raspberry ketone is mediated via inhibition of the NF-κB/TNF-α/caspase axis and mitochondrial apoptosis in chemically induced acute liver injury. Toxicology Research 8:5, pages 663-676.
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Yang Xu, Li Zhang, Qing Wang, Gan Luo & Xiaoyan Gao. (2019) An integrated strategy based on characteristic fragment filter supplemented by multivariate statistical analysis in multi-stage mass spectrometry chromatograms for the large-scale detection and identification of natural plant-derived components in rat: The rhubarb case. Journal of Pharmaceutical and Biomedical Analysis 174, pages 89-103.
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Žiga Jakopin. (2019) Risks associated with fat burners: A toxicological perspective. Food and Chemical Toxicology 123, pages 205-224.
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. (2016) Safety and efficacy of aromatic ketones, secondary alcohols and related esters belonging to chemical group 21 when used as flavourings for all animal species. EFSA Journal 14:8.
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Lea Bredsdorff, Eva Bay Wedebye, Nikolai Georgiev Nikolov, Torben Hallas-Møller & Kirsten Pilegaard. (2015) Raspberry ketone in food supplements – High intake, few toxicity data – A cause for safety concern?. Regulatory Toxicology and Pharmacology 73:1, pages 196-200.
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Lili WangXianjun MengFengqing Zhang. (2012) Raspberry Ketone Protects Rats Fed High-Fat Diets Against Nonalcoholic Steatohepatitis. Journal of Medicinal Food 15:5, pages 495-503.
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Wang Lili, Zhang Yan, Meng Xianjun & Zhao Wei. (2011) Experimental study on the mechanism of raspberry ketone on simple obesity and insulin resistance relevant to obesity. Experimental study on the mechanism of raspberry ketone on simple obesity and insulin resistance relevant to obesity.
Chie Morimoto, Yurie Satoh, Mariko Hara, Shintaro Inoue, Takahiro Tsujita & Hiromichi Okuda. (2005) Anti-obese action of raspberry ketone. Life Sciences 77:2, pages 194-204.
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