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Xenobiotica
the fate of foreign compounds in biological systems
Volume 12, 1982 - Issue 5
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Research Article

The metabolism of [14C]cimetidine in man

S. C. Mitchell Department of Biochemical and Experimental Pharmacology, St Mary's Hospital Medical School, Paddington, London W2 1PG, UK
,
J. R. Idle Department of Biochemical and Experimental Pharmacology, St Mary's Hospital Medical School, Paddington, London W2 1PG, UK
&
R. L. Smith Department of Biochemical and Experimental Pharmacology, St Mary's Hospital Medical School, Paddington, London W2 1PG, UK
Pages 283-292 | Received 12 Nov 1981, Published online: 22 Sep 2008

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Evita Vandenbossche, Christopher Lucas, Lata Mistry, Emma Garfield, Stephen C. Mitchell & Glyn B. Steventon. (2016) Phenylalanine monooxygenase and the sulfur oxygenation of S-carboxymethyl-l-cysteine in mice. Xenobiotica 46:4, pages 379-384.
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Sarah J. Roffey, R. Scott Obach, Jenny I. Gedge & Dennis A. Smith. (2007) What is the Objective of the Mass Balance Study? A Retrospective Analysis of Data in Animal and Human Excretion Studies Employing Radiolabeled Drugs. Drug Metabolism Reviews 39:1, pages 17-43.
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Johan W. Jonker, Els Wagenaar, Carla A. A. M. Mol, Marije Buitelaar, Hermann Koepsell, Johan W. Smit & Alfred H. Schinkel. (2001) Reduced Hepatic Uptake and Intestinal Excretion of Organic Cations in Mice with a Targeted Disruption of the Organic Cation Transporter 1 (Oct1 [Slc22a1]) Gene. Molecular and Cellular Biology 21:16, pages 5471-5477.
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S. C. Mitchell & R. H. Waring. (1989) The fate of cimetidine sulphoxide in the guinea pig. Xenobiotica 19:2, pages 179-188.
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M. Schulz & A. Schmoldt. (1988) On the sulphoxidation of cimetidine and etintidine by rat and human liver microsomes. Xenobiotica 18:8, pages 983-989.
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Elena Rozman, M.Teresa Galcerán & Carlos Albet. (1997) Determination of ebrotidine and its metabolites in human urine by reversed-phase ion-pair high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications 688:1, pages 107-115.
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S.C. Lee & A.G. Renwick. (1995) Sulphoxide reduction by rat and rabbit tissues in vitro. Biochemical Pharmacology 49:11, pages 1557-1565.
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Katerina Pattichis & Louis L. Louca. (1995) Histamine, Histamine H2-Receptor Antagonists, Gastric Acid Secretion and Ulcers: An Overview. Drug Metabolism and Drug Interactions 12:1, pages 1-36.
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Ryta A. Kuzel, Satvinder K. Bhasin, Harriet G. Oldham, Lyaquatali A. Damani, Jo Murphy, Patrick Camilleri & Andrew J. Hutt. (2004) Investigations into the chirality of the metabolic sulfoxidation of cimetidine. Chirality 6:8, pages 607-614.
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Tjong-Lie Ching, Guido R.M.M. Haenen & Aalt Bast. (1993) Cimetidine and other H2 receptor antagonists as powerful hydroxyl radical scavengers. Chemico-Biological Interactions 86:2, pages 119-127.
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Andrea Resetar, Douglas Minick & Thomas Spector. (1991) Glucuronidation of 3′-azido-3′-deoxythymidine catalyzed by human liver UDP-glucuronosyltransferase. Biochemical Pharmacology 42:3, pages 559-568.
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David L. Marcus, Harriet Nadel, George Lew & Michael L. Freedman. (1990) Cimetidine Suppresses Chemically Induced Experimental Hepatic Porphyria. The American Journal of the Medical Sciences 300:4, pages 214-217.
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Shiew‐Mei Huang, Howard S. Weintraub, Robert Abels, William Harris, Thomas B. Marriott, John D. Arnold & Joseph Boccagno. (2006) Clinical pharmacokinetics of etintidine. Biopharmaceutics & Drug Disposition 9:5, pages 477-486.
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Shmuel Zbaida, Rami Kariv & Paula Fischer. (1988) The role of iron chelates on the selectivity of Fenton reagent in hydroxylation, N-demethylation, and sulfoxidation of cimetidine: A novel biomimetic model for the regioselectivity of cytochrome P-450. Archives of Biochemistry and Biophysics 261:1, pages 12-15.
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S.C. Mitchell. (1988) BIOLOGICAL CONSEQUENCES OF DRUG SULPHOXIDATION. Drug Metabolism and Drug Interactions 6:3-4.
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Shiew‐Mei Huang, Larry S. Abrams, Thomas B. Marriott & Howard S. Weintraub. (2006) Pharmacokinetics and bioavailability of etintidine in beagle dogs: Effects of routes of administration, doses, dosage forms, and chronic dosing. Biopharmaceutics & Drug Disposition 9:1, pages 71-83.
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H.Andrew Strong & Michael Spino. (1987) Highly sensitive determination of cimetidine and its metabolites in serum and urine by high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications 422, pages 301-308.
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R. M. Lee & R. D. McDowall. (1986) RECENT ADVANCES IN PHARMACEUTICAL CHEMISTRY—REVIEW II HISTAMINE H 2 -RECEPTOR ANTAGONISTS . Journal of Clinical Pharmacy and Therapeutics 11:6, pages 389-408.
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M.S. Lennard, H.K. Crewe, G.T. Tucker & H.F. Woods. (1986) Metoprolol oxidation by rat liver microsomes. Biochemical Pharmacology 35:16, pages 2757-2761.
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Shmuel ZBAIDA, Rami KARIV, Paula FISCHER, Judith SILMAN‐GREENSPAN & Zeev TASHMA. (2005) Reaction of cimetidine with Fenton reagent. European Journal of Biochemistry 154:3, pages 603-605.
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P.A.F. Dixon & A.U. Udegha. (1986) The effect of some hepatotoxins on the sulphoxidation of cimetidine in rat. Comparative Biochemistry and Physiology Part C: Comparative Pharmacology 83:2, pages 385-386.
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Stephen M. Stefanick, Charles F. Kasulanis, Seymour D. Levine & Arthur C. Fabian. (2006) Synthesis of 14 C‐labelled etintidine hydrochloride . Journal of Labelled Compounds and Radiopharmaceuticals 22:7, pages 677-685.
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P.A.F. Dixon, N.O. Okereke & O.A. Ogundahunsi. (1985) Influence of species and drug pretreatment on the metabolic oxidation of cimeticline and metiamide. Biochemical Pharmacology 34:11, pages 2028-2030.
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S. Emery, H.G. Oldham, S.J. Norman & R.J. Chenery. (1985) The effect of cimetidine and ranitidine on paracetamol glucuronidation and sulphation in cultured rat hepatocytes. Biochemical Pharmacology 34:9, pages 1415-1421.
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Shmuel Zbaida, Judith Silman‐Greenspan, Shimona Yosselson‐Superstine & Edna Merin. (2006) In vitro studies on the metabolism of cimetidine by rat liver microsomes—identification of a new N ‐desmethylcimetidine metabolite . Biopharmaceutics & Drug Disposition 5:4, pages 415-419.
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