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Xenobiotica
the fate of foreign compounds in biological systems
Volume 12, 1982 - Issue 5
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Research Article

Effects of endotoxin upon rat hepatic microsomal drug metabolism in vivo and in vitro

B. R. Sonawane Departments of Pediatrics and Pharmacology, University of Pennsylvania, School of Medicine and Children's Hospital of Philadelphia, PA, 19104, USA
,
S. J. Yaffe Departments of Pediatrics and Pharmacology, University of Pennsylvania, School of Medicine and Children's Hospital of Philadelphia, PA, 19104, USA
&
C. M. Witmer Department of Pharmacology, Thomas Jefferson University, Philadelphia, PA, 19107, USA
Pages 303-313 | Received 24 Nov 1981, Published online: 22 Sep 2008

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Read on this site (3)

Hirokazu Hara. (2000) Inhibitory effect of nitric oxide on the induction of cytochrome P450 3A4 mRNA by 1,25-dihydroxyvitamin D3 in Caco-2 cells. Free Radical Research 33:3, pages 279-285.
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Edward T. Morgan. (1997) Regulation of Cytochromes P450 During Inflammation and Infection. Drug Metabolism Reviews 29:4, pages 1129-1188.
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Juzar S. Kaka, Musbah O.M. Tanira & Khalil I. Al-Khamls. (1989) Disposition Kinetics of Cimetidine and Ranitidine in Endotoxin Pretreated Rats. Drug and Chemical Toxicology 12:1, pages 49-59.
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Articles from other publishers (20)

Finn Redke & Sven Björkman. (1994) Endotoxin-induced Fever Increases the Clearance of Methohexitone in Rabbits. Journal of Pharmacy and Pharmacology 46:11, pages 887-891.
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Roland N. Dickerson & Scott L. Charland. (2012) The Effect of Sepsis During Parenteral Nutrition on Hepatic Microsomal Function in Rats. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 22:9, pages 1084-1090.
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Hirokazu Hara & Tetsuo Adachi. (2002) Contribution of Hepatocyte Nuclear Factor-4 to Down-Regulation of CYP2D6 Gene Expression by Nitric Oxide . Molecular Pharmacology 61:1, pages 194-200.
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Kenneth W Renton. (2001) Alteration of drug biotransformation and elimination during infection and inflammation. Pharmacology & Therapeutics 92:2-3, pages 147-163.
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David A Kuhl, Jay F Mouser, James Travis Methvin, Emily B Hak, Lawrence J Hak & Roland N Dickerson. (1998) Alterations in N-acetylation of 3-methylhistidine in endotoxemic parenterally fed rats. Nutrition 14:9, pages 678-682.
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David S. McKindley, Scott Hanes & Bradley A. Boucher. (2012) Hepatic Drug Metabolism in Critical Illness. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 18:4, pages 759-778.
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Oleg G. Khatsenko, Alan R. Boobis & Steven S. Gross. (1997) Evidence for nitric oxide participation in down-regulation of CYP2B1/2 gene expression at the pretranslational level. Toxicology Letters 90:2-3, pages 207-216.
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Sven Björkman & Finn Redke. (1996) Influence of Escherichia coli Endotoxin on the Pharmacokinetics and Respiratory Depressant Effect of Alfentanil in Rabbits. Journal of Pharmaceutical Sciences 85:7, pages 680-684.
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J. SCHRÖTER, C. WANDEL, H. BÖHRER, H. SCHMIDT, B. W. BÖTTIGER & E. MARTIN. (2007) Lignocaine metabolite formation: an indicator for liver dysfunction and predictor of survival in surgical intensive care patients. Anaesthesia 50:10, pages 850-854.
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Grace L. Earl-Salotti & Scott L. Charland. (2016) Review: The Effect of Parenteral Nutrition on Hepatic Cytochrome P-450. Journal of Parenteral and Enteral Nutrition 18:5, pages 458-465.
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Philip I. Craig, Michael Murray & Geoffrey C. Farrell. (1992) Interferon suppresses the isoform-specific activities of hepatic cytochrome P450 in female rats. Biochemical Pharmacology 43:4, pages 908-910.
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Steven I. Shedlofsky, Niel C. Hoglen, Larry E. Rodman, Ron Honchel, Farrel R. Robinson, Alice T. Swim, Craig J. McClain & Larry W. Robertson. (1991) 3,3′,4,4′-Tetrabromobiphenyl sensitizes rats to the hepatotoxic effects of endotoxin by a mechanism that involves more than tumor necrosis factor. Hepatology 14:6, pages 1201-1208.
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F. Hawker. (2019) Liver Dysfunction in Critical Illness. Anaesthesia and Intensive Care 19:2, pages 165-181.
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C. Sprong, Y.M.W. Janssen & P.J.A. Borm. (1991) The role of reactive oxygen species, cytokines and cytochrome P450 in pulmonary damage due to hyperoxia. Medical Hypotheses 34:4, pages 296-299.
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Juzar S. Kaka, Khalil Al-Khamis & Musbah O. M. Tanira. (1990) Evaluation of hepatic dysfunction in endotoxin pretreated rats using tolbutamide as a marker. European Journal of Drug Metabolism and Pharmacokinetics 15:3, pages 203-209.
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Cees J.A. Doelman & Aalt Bast. (1990) Oxygen radicals in lung pathology. Free Radical Biology and Medicine 9:5, pages 381-400.
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Jorge A. Coto & Joseph F. Williams. (1989) Effect of endotoxin to differentially affect cytochrome P-450 monooxygenase activities of untreated rats and animals induced with phenobarbital or 3-methylcholanthrene. International Journal of Immunopharmacology 11:6, pages 623-628.
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G.C. Farrell. (1987) Drug metabolism in extrahepatic diseases. Pharmacology & Therapeutics 35:3, pages 375-404.
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Richard L. Slaughter & James M. Hassett. (2016) Hepatic Drug Clearance following Traumatic Injury. Drug Intelligence & Clinical Pharmacy 19:11, pages 799-806.
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M. Falzon, A.S. Milton & M.D. Burke. (1984) Are the decreases in hepatic cytochrome P-450 and other drug-metabolising enzymes caused by indomethacin in vivo mediated by intestinal bacterial endotoxins?. Biochemical Pharmacology 33:8, pages 1285-1292.
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