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Xenobiotica
the fate of foreign compounds in biological systems
Volume 12, 1982 - Issue 7
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Research Article

Studies on the metabolism of dimethylnitrosamine in vitro by rat-liver preparations.: I. Comparison with mixed-function oxidase enzymes

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Pages 435-445 | Received 11 Feb 1982, Published online: 22 Sep 2008

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Lisa M. Howe, Harry W. Boothe, Matthew W. Miller, Dawn M. Boothe. (2000) A Canine Model of Multiple Portosystemic Shunting. Journal of Investigative Surgery 13:1, pages 45-57.
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B. G. Lake, M. A. Collins, Rosalyn A. Harris, J. C. Phillips, R. C. Cottrell, R. C. Longland & S. D. Gangolli. (1982) Studies on the metabolism of dimethylnitrosamine in vitro by rat-liver preparations.: III. Effect of cobaltous chloride treatment. Xenobiotica 12:9, pages 581-590.
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B. G. Lake, Rosalyn A. Harris, M. A. Collins, R. C. Cottrell, J. C. Phillips & S. D. Gangolli. (1982) Studies on the metabolism of dimethylnitrosamine in vitro by rat-liver preparations.: II. Inhibition by substrates and inhibitors of monoamine oxidase. Xenobiotica 12:9, pages 567-579.
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Articles from other publishers (15)

Gerald L. Jr. Kennedy. 2003. Patty's Toxicology. Patty's Toxicology 1 82 .
Tae Cheon Jeong, Kyu-Hwan Yang & Michael P. Holsapple. (1994) Recovery of dimethylnitrosamine-induced immunosuppression by pargyline in the mixed cultures of murine hepatocytes and splenocytes. Life Sciences 54:9, pages 605-613.
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G.D. Heaton & A.G. Renwick. (1991) The effects of high dietary concentrations of saccharin on in vitro metabolism of xenobiotics in rats. Food and Chemical Toxicology 29:5, pages 297-303.
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Helen G. Haggerty & Michael P. Holsapple. (1990) Role of metabolism in dimethylnitrosamine-induced immunosuppression: a review. Toxicology 63:1, pages 1-23.
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Peter R. M. Kerklaan, Susan Bouter, Jaap A. Zijlstra & Georges R. Mohn. (1986) The effect of mixed-function oxidase and amine oxidase inhibitors on the activation of dialkylnitrosamines and 1,2-dimethylhydrazine to bacterial mutagens in mice. Journal of Cancer Research and Clinical Oncology 111:3, pages 196-202.
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John A. Craft. (1985) Effects of pyrazole on nitrosodimethylamine demethylase and other microsomal xenobiotic metabolising activities. Biochemical Pharmacology 34:9, pages 1507-1513.
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Toru Kawanishi, Yasuo Ohno, Atsushi Takahashi, Akira Takanara, Yutaka Kasuya & Yoshihito Omori. (1985) Relation between hepatic microsomal metabolism of N-nitrosamines and cytochrome P-450 species. Biochemical Pharmacology 34:7, pages 919-924.
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B. Bertram, E. Frei, H. R. Scherf, J. Schuhmacher, A. M. Tacchi & M. Wiessler. (1985) Influence of a prolonged treatment with disulfiram andd(-)penicillamine on nitrosodiethylamine-induced biological and biochemical effects in rats. Journal of Cancer Research and Clinical Oncology 109:1, pages 9-15.
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Karen Lynn Kaul & Raymond F. Novak. (1984) Induction of rabbit hepatic microsomal cytochrome P-450 by imidazole: Enhanced metabolic activity and altered substrate specificity. Archives of Biochemistry and Biophysics 235:2, pages 470-481.
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Tomäs Mendoza‐Figueroa. (2006) Dimethylnitrosamine genotoxicity in rat liver primary cell cultures with low cytochrome P‐450 levels. Journal of Applied Toxicology 4:6, pages 297-303.
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T. Kawanishi, Y. Ohno, A. Takahashi, A. Takanaka, Y. Kasuya & Y. Omori. (1984) Nature of N-nitrosodimethylamine demethylase. Archives of Toxicology 56:1, pages 7-11.
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Eduard Müller, Regina Kettler & Manfred Wiessler. (2006) Chemie der Nitrosamine, IV. Synthesen von α‐ C ‐funktionellen N ‐Nitrosodialkylaminen: Ester und Ether von 1‐[(Alkyl)(nitroso)amino]alkoholen . Liebigs Annalen der Chemie 1984:8, pages 1468-1493.
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P. Schmezer, R.G. Klein & B. Spiegelhalder. (1984) Urinary excretion of N-nitrosodimethylamine in rats after Thalamonal narcosis. Cancer Letters 23:3, pages 351-353.
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Steven R. Koepke, Yves Tondeur, James G. Farrelly, Mary L. Stewart, Christopher J. Michejda & Marilyn B. Kroeger-Koepke. (1984) Metabolism of 15N-labelled N-nitrosodimethylamine and N-nitroso-N-methylaniline by isolated rat hepatocytes. Biochemical Pharmacology 33:9, pages 1509-1513.
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Toru Kawanishi, Atsushi Takahashi, Yasuo Ohno, Akira Takanaka, Yutaka Kasuya & Yoshihito Omori. (1983) New method for quantitative measurement of N-nitrosodimethylamine formation in the whole mouse. Archives of Toxicology 54:4, pages 323-330.
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