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Xenobiotica
the fate of foreign compounds in biological systems
Volume 13, 1983 - Issue 1
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Research Article

Irreversible binding of acrylonitrile to nucleic acids

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Pages 19-25 | Received 20 Jul 1982, Published online: 22 Sep 2008

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Richard J. Albertini, Christopher R. Kirman & Dale E. Strother. (2023) Acrylonitrile’s genotoxicity profile: mutagenicity in search of an underlying molecular mechanism. Critical Reviews in Toxicology 53:2, pages 69-116.
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M. E. (Bette) Meek, John R. Bucher, Samuel M. Cohen, Vicki Dellarco, Richard N. Hill, Lois D. Lehman-McKeeman, David G. Longfellow, Timothy Pastoor, Jennifer Seed & Dorothy E. Patton. (2003) A Framework for Human Relevance Analysis of Information on Carcinogenic Modes of Action. Critical Reviews in Toxicology 33:6, pages 591-653.
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G. Long, M. E. Meek & D. Koniecki. (2001) ACRYLONITRILE: HAZARD CHARACTERIZATION AND EXPOSURE-RESPONSE ANALYSIS. Journal of Environmental Science and Health, Part C 19:1, pages 45-75.
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Articles from other publishers (22)

Tetyana Kobets, Michael J Iatropoulos & Gary M Williams. (2022) Acrylonitrile induction of rodent neoplasia: Potential mechanism of action and relevance to humans. Toxicology Research and Application 6, pages 239784732110553.
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Gary M. Williams, Tetyana Kobets, Jian-Dong Duan & Michael J. Iatropoulos. (2017) Assessment of DNA Binding and Oxidative DNA Damage by Acrylonitrile in Two Rat Target Tissues of Carcinogenicity: Implications for the Mechanism of Action. Chemical Research in Toxicology 30:7, pages 1470-1480.
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H. M. Bolt & J. Lewalter. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 184 192 .
J. Lewalter & H. M. Bolt. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 16 .
Ricarda Thier, Jürgen Lewalter, Silvia Selinski & Hermann M Bolt. (2002) Possible impact of human CYP2E1 polymorphisms on the metabolism of acrylonitrile. Toxicology Letters 128:1-3, pages 249-255.
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Ricarda Thier, Heiko Balkenhol, Jürgen Lewalter, Silvia Selinski, Anja Dommermuth & Hermann M Bolt. (2001) Influence of polymorphisms of the human glutathione transferases and cytochrome P450 2E1 enzyme on the metabolism and toxicity of ethylene oxide and acrylonitrile. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 482:1-2, pages 41-46.
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A Léonard, G.B Gerber, C Stecca, J Rueff, H Borba, P.B Farmer, R.J Sram, A.E Czeizel & I Kalina. (1999) Mutagenicity, carcinogenicity, and teratogenicity of acrylonitrile. Mutation Research/Reviews in Mutation Research 436:3, pages 263-283.
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J. Whysner, P.M. Ross, C.C. Conaway, L.K. Verna & G.M. Williams. (1998) Evaluation of Possible Genotoxic Mechanisms for Acrylonitrile Tumorigenicity. Regulatory Toxicology and Pharmacology 27:3, pages 217-239.
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Jerome J. Solomon, Udai S. Singh & Alvin Segal. (1993) In vitro reactions of 2-cyanoethylene oxide with calf thymus DNA. Chemico-Biological Interactions 88:2-3, pages 115-135.
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Mayo Uziel, Nancy B. Munro, D. Sue Katz, Tuan Vo-Dinh, Elaine A. Zeighami, Michael D. Waters & Jack D. Griffith. (1992) DNA adduct formation by 12 chemicals with populations potentially suitable for molecular epidemiological studies. Mutation Research/Reviews in Genetic Toxicology 277:1, pages 35-90.
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Pavel Vodička, Ivan Gut & Emil Frantík. (1990) Effects of inhaled acrylic acid derivatives in rats. Toxicology 65:1-2, pages 209-221.
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N. P. E. Vermeulen, J. de Jong, E. J. C. van Bergen & R. T. H. van Welie. (1989) N-acetyl-S-(2-hydroxyethyl)-L-cysteine as a potential tool in biological monitoring studies?. Archives of Toxicology 63:3, pages 173-184.
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Leslie Recio & Thomas R. Skopek. (1988) Mutagenicity of acrylonitrile and its metabolite 2-cyanoethylene oxide in human lymphoblasts in vitro. Mutation Research/Genetic Toxicology 206:2, pages 297-305.
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G.T. Gallagher, E.A. Maull, K. KovacsS. Szabo. (2016) Neoplasms in Rats Ingesting Acrylonitrile for Two Years. Journal of the American College of Toxicology 7:5, pages 603-615.
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Denis Pilon, Alan E. Roberts & Douglas E. Rickert. (1988) Effect of glutathione depletion on the irreversible association of acrylonitrile with tissue macromolecules after oral administration to rats. Toxicology and Applied Pharmacology 95:2, pages 311-320.
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H. M. Bolt, R. J. Laib, H. Peter & H. Ottenw�lder. (1986) DNA adducts of halogenated hydrocarbons. Journal of Cancer Research and Clinical Oncology 112:2, pages 92-96.
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Sipra Banerjee & Alvin Segal. (1986) In vitro transformation of C3H/10T1/2 and NIH/3T3 cells by acrylonitrile and acrylamide. Cancer Letters 32:3, pages 293-304.
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Lila Graham & Gerald L. Mechanic. (1986) [14C]acrylonitrile: Preparation via a stable tosylate intermediate and quantitative reaction with amine residues in collagen. Analytical Biochemistry 153:2, pages 354-358.
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J J Solomon & A Segal. (1985) Direct alkylation of calf thymus DNA by acrylonitrile. Isolation of cyanoethyl adducts of guanine and thymine and carboxyethyl adducts of adenine and cytosine.. Environmental Health Perspectives 62, pages 227-230.
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J.J. Solomon, I.L. Cote, M. Wortman, K. Decker & A. Segal. (1984) In vitro alkylation of calf thymus DNA by acrylonitrile. Isolation of cyanoethyl-adducts of guanine and thymine and carboxyethyl-adducts of adenine and cytosine. Chemico-Biological Interactions 51:2, pages 167-190.
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M. Lambotte-Vandepaer & M. Duverger-van Bogaert. (1984) Genotoxic properties of acrylonitrile. Mutation Research/Reviews in Genetic Toxicology 134:1, pages 49-59.
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A. Buchter, H. Peter & H. M. Bolt. (1984) N-acetyl-cystein als antidot bei akzidenteller acrylnitril-intoxikationN-acetyl-cysteine as an antidote in accidental acrylonitrile intoxications. International Archives of Occupational and Environmental Health 53:4, pages 311-319.
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