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Xenobiotica
the fate of foreign compounds in biological systems
Volume 13, 1983 - Issue 10
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Research Article

Biliary excretion and enterohepatic circulation of paracetamol in the rat

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Pages 591-596 | Received 07 Feb 1983, Published online: 22 Sep 2008

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Lotte C. G. Hoegberg, Greene Shepherd, David M. Wood, Jami Johnson, Robert S. Hoffman, E. Martin Caravati, Wui Ling Chan, Silas W. Smith, Kent R. Olson & Sophie Gosselin. (2021) Systematic review on the use of activated charcoal for gastrointestinal decontamination following acute oral overdose. Clinical Toxicology 59:12, pages 1196-1227.
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J. Michael Tredger, H. M. Smith, R. B. Read & R. Williams. (1986) Effects of ethanol ingestion on the metabolism of a hepatotoxic dose of paracetamol in mice. Xenobiotica 16:7, pages 661-670.
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Petra Mészáros, Sára Kovács, Győző Kulcsár, Melinda Páskuj & Attila Almási. (2022) Investigation of Intestinal Absorption and Excretion of Paracetamol in Streptozotocin-Induced Hyperglycemia. International Journal of Molecular Sciences 23:19, pages 11913.
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Mira Merdas, Mélanie Lagarrigue, Thierry Umbdenstock, Antoine Lhumeau, Françoise Dartiguelongue, Quentin Vanbellingen, Georges Da Violante & Charles Pineau. (2021) Study of the Distribution of Acetaminophen and Its Metabolites in Rats, from the Whole-Body to Isolated Organ Levels, by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging after On-Tissue Chemical Derivatization. Analytical Chemistry 93:39, pages 13242-13250.
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Ningning Zheng, Yu Gu, Ying Hong, Lili Sheng, Linlin Chen, Feng Zhang, Jie Hou, Weidong Zhang, Zean Zhang, Wei Jia & Houkai Li. (2020) Vancomycin pretreatment attenuates acetaminophen-induced liver injury through 2-hydroxybutyric acid. Journal of Pharmaceutical Analysis 10:6, pages 560-570.
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Ian Sorrell, Rebecca J Shipley, Sophie Regan, Iain Gardner, Michael P. Storm, Marianne Ellis, John Ward, Dominic Williams, Pratibha Mistry, José Domingo Salazar, Andrew Scott & Steven Webb. (2019) Mathematical modelling of a liver hollow fibre bioreactor. Journal of Theoretical Biology 475, pages 25-33.
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Selahaddin Sezgin, Reham Hassan, Sebastian Zühlke, Lars Kuepfer, Jan G. Hengstler, Michael Spiteller & Ahmed Ghallab. (2018) Spatio-temporal visualization of the distribution of acetaminophen as well as its metabolites and adducts in mouse livers by MALDI MSI. Archives of Toxicology 92:9, pages 2963-2977.
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Angela Wehr. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 4 .
Joost Westerhout, Bart Ploeger, Jean Smeets, Meindert Danhof & Elizabeth C. M. de Lange. (2012) Physiologically Based Pharmacokinetic Modeling to Investigate Regional Brain Distribution Kinetics in Rats. The AAPS Journal 14:3, pages 543-553.
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Soo Hyun Lee, Ji Hye An, Hwa Jeong Lee & Byung Hwa Jung. (2012) Evaluation of pharmacokinetic differences of acetaminophen in pseudo germ-free rats. Biopharmaceutics & Drug Disposition 33:6, pages 292-303.
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Robert G. Hendrickson, Nathanael J. McKeown, Patrick L. West & Christopher R. Burke. (2010) Bactrian (“Double Hump”) Acetaminophen Pharmacokinetics: A Case Series and Review of the Literature. Journal of Medical Toxicology 6:3, pages 337-344.
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Carolina I. Ghanem, María L. Ruiz, Silvina S.M. Villanueva, Marcelo Luquita, Susana Llesuy, Viviana A. Catania, Laura A. Bengochea & Aldo D. Mottino. (2009) Effect of repeated administration with subtoxic doses of acetaminophen to rats on enterohepatic recirculation of a subsequent toxic dose. Biochemical Pharmacology 77:10, pages 1621-1628.
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Sun J. Kim, Min Y. Lee, Do Y. Kwon, Sung Y. Kim & Young C. Kim. (2009) Alteration in Metabolism and Toxicity of Acetaminophen Upon Repeated Administration in Rats. Journal of Pharmacological Sciences 111:2, pages 175-181.
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CK Gelotte, JF Auiler, JM Lynch, AR Temple & JT Slattery. (2008) Response to “Upregulation of Multidrug Resistance-associated Protein 3 by Acetaminophen May Help to Increase Its Own Clearance”. Clinical Pharmacology & Therapeutics 83:4, pages 528-528.
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Chuan Chen, Gayle E. Hennig & José E. Manautou. (2003) HEPATOBILIARY EXCRETION OF ACETAMINOPHEN GLUTATHIONE CONJUGATE AND ITS DERIVATIVES IN TRANSPORT-DEFICIENT (TR - ) HYPERBILIRUBINEMIC RATS . Drug Metabolism and Disposition 31:6, pages 798-804.
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Paula Schaiquevich, Ada Niselman & Modesto Rubio. (2002) Importance of entero‐salivary recirculation in paracetamol pharmacokinetics. Biopharmaceutics & Drug Disposition 23:6, pages 245-249.
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Michael S. Roberts, Beatrice M. Magnusson, Frank J. Burczynski & Michael Weiss. (2002) Enterohepatic Circulation. Clinical Pharmacokinetics 41:10, pages 751-790.
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V.M Silva, C Chen, G.E Hennig, H.E Whiteley & J.E Manautou. (2001) Changes in susceptibility to acetaminophen-induced liver injury by the organic anion indocyanine green. Food and Chemical Toxicology 39:3, pages 271-278.
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Katsuhiko Ishida, Masashi Sakazume, Masami Watanabe, Nami Hirai, Hisashi Ikegami, Toshiharu Sakai & Kunio Doi. (1997) Effects of fructose-induced hypertriglyceridemia on hepatorenal toxicity of acetaminophen in rats: Role of pharmacokinetics and metabolism of acetaminophen. Experimental and Toxicologic Pathology 49:3-4, pages 207-215.
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Sarah Jaw & Elizabeth H. Jeffery. (1993) Interaction of caffeine with acetaminophen. Biochemical Pharmacology 46:3, pages 493-501.
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S.K. Cole, M.J. Story, T. Laudanski, M. Dwyer, D. Attwood, J. Robertson & S.G. Barnwell. (1992) Targeting drugs to the enterohepatic circulation: A potential drug delivery system designed to enhance the bioavailability of indomethacin. International Journal of Pharmaceutics 80:1-3, pages 63-73.
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W. Möller‐Hartmann & C.‐P. Siegers. (2006) Nephrotoxicity of paracetamol in the rat—mechanistic and therapeutic aspects. Journal of Applied Toxicology 11:2, pages 141-146.
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Mohamed A. Al-Meshal, Yousry M. El-Sayed, Abdulaziz A. Al-Angary, Khalil M. Lutfi & M.Wafik Gouda. (1990) Interruption of the enterohepatic circulation of indomethacin by cholestyramine in rabbits. International Journal of Pharmaceutics 64:2-3, pages 155-160.
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K. P. R. Gartland, C. T. Eason, F. W. Bonner & J. K. Nicholson. (1990) Effects of biliary cannulation and buthionine sulphoximine pretreatment on the nephrotoxicity of para-aminophenol in the Fischer 344 rat. Archives of Toxicology 64:1, pages 14-25.
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K.P.R. Gartland, C.T. Eason, K.E. Wade, F.W. Bonner & J.K. Nicholson. (1989) Proton NMR spectroscopy of bile for monitoring the excretion of endogenous and xenobiotic metabolites: Application to para-aminophenol. Journal of Pharmaceutical and Biomedical Analysis 7:6, pages 699-707.
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K. P. R. Gartland, C. T. Eason, F. W. Bonner & J. K. Nicholson. 1989. Nephrotoxicity. Nephrotoxicity 423 432 .
Lisa B.G. Tee, Donald S. Davies, Caroline E. Seddon & Alan R. Boobis. (1987) Species differences in the hepatotoxicity of paracetamol are due to differences in the rate of conversion to its cytotoxic metabolite. Biochemical Pharmacology 36:7, pages 1041-1052.
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L. A. Skoglund, K. Ingebrigtsen, I. Nafstad & J. Høgset Jansen. (2006) Time development of distribution and toxicity following single toxic APAP doses in male BOM:NMRI mice. Journal of Applied Toxicology 7:1, pages 1-6.
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KS Jayasinghe, CJ Roberts & AE Read. (1986) Is biliary excretion of paracetamol significant in man?. British Journal of Clinical Pharmacology 22:3, pages 363-366.
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J.R. WEISER, J. PETERSEN, D. DENNIN, R. PENTZ & C.-P. SIEGERS. 1986. Receptors and Centrally Acting Drugs Pharmacokinetics and Drug Metabolism. Receptors and Centrally Acting Drugs Pharmacokinetics and Drug Metabolism 465 468 .
M.R. Clements, T.M. Chalmers & D.R. Fraser. (1984) ENTEROHEPATIC CIRCULATION OF VITAMIN D: A REAPPRAISAL OF THE HYPOTHESIS. The Lancet 323:8391, pages 1376-1379.
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